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Alessandra Griffa

Cette personne a quitté l’EPFL

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Publications associées (80)

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The topology of structural brain connectivity in diseases and spatio-temporal connectomics

Alessandra Griffa

The brain is a complex system, composed of multiple neural units interconnected at different spatial and temporal scales. Diffusion MRI allows probing in vivo the anatomical connectivity between different cortical areas through white matter tracts. In para ...

EPFL2015

Whole-brain structural connectivity in temporal lobe epilepsy: a Diffusion Spectrum Imaging study

Jean-Philippe Thiran, Alessandro Daducci, Alessandra Griffa, Alia Lemkaddem, François Lazeyras

Introduction: Medial Temporal Lobe Epilepsy (mTLE) with hippocampal sclerosis is the most frequent cause of drug-resistant focal epilepsy in adults. These patients suffer from widespread subtle white matter abnormalities and abnormal functional connectivit ...

2012

Brain structure-function coupling provides signatures for task decoding and individual fingerprinting

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Maria Giulia Preti, Enrico Amico, Raphaël Pierre Liégeois

Brain signatures of functional activity have shown promising results in both decoding brain states, meaning distinguishing between different tasks, and fingerprinting, that is identifying individuals within a large group. Importantly, these brain signature ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Cortical and subcortical changes in resting-state neuronal activity and connectivity in early symptomatic ALS and advanced frontotemporal dementia

Alessandra Griffa

The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural vari ...

ELSEVIER SCI LTD2022

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Alessandra Griffa

The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

Oxford University Press2025

Characterizing the connectome in schizophrenia with diffusion spectrum imaging

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa

Schizophrenia is a complex psychiatric disorder characterized by disabling symptoms and cognitive deficit. Recent neuroimaging findings suggest that large parts of the brain are affected by the disease, and that the capacity of functional integration betwe ...

Wiley-Blackwell2015

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Alessandra Griffa

Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...

SPRINGER WIEN2021

Structural connectomics in brain diseases

Jean-Philippe Thiran, Patric Hagmann, Alessandra Griffa, Philipp Baumann

Imaging the connectome in vivo has become feasible through the integration of several rapidly developing fields of science and engineering, namely magnetic resonance imaging and in particular diffusion MRI on one side, image processing and network theory o ...

Elsevier2013

Comparing connectomes across subjects and populations at different scales

Jean-Philippe Thiran, Stephan Morgenthaler, Alessandra Griffa, Elda Fischi Gomez, Patric Hagmann, Djalel Eddine Meskaldji

Brain connectivity can be represented by a network that enables the comparison of the different patterns of struc- tural and functional connectivity among individuals. In the literature, two levels ofstatistical analysis have been con- sidered in comparing ...

2013

Markers of limbic system damage following SARS-CoV-2 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca

Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...

OXFORD UNIV PRESS2023

Magnetoencephalography Brain Signatures Relate to Cognition and Cognitive Reserve in the Oldest-Old: The EMIF-AD 90+Study

Alessandra Griffa

The oldest-old subjects represent the fastest growing segment of society and are at high risk for dementia with a prevalence of up to 40%. Lifestyle factors, such as lifelong participation in cognitive and leisure activities, may contribute to individual c ...

FRONTIERS MEDIA SA2021

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca

Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Sensorimotor Induction of Auditory Misattribution in Psychosis is Linked to Neural Disconnectivity

Olaf Blanke, Alessandra Griffa, Patric Hagmann, Andrea Serino, Roy Salomon, Giulio Rognini, Silvia Marchesotti

Background: Schneiderian first rank symptoms (FRS) are characterized by a diminished demarcation of self-other boundaries, causing misattribution of self-generated thoughts and actions to external sources. We have shown that introducing sensorimotor predic ...

2018

CSF tap test in idiopathic normal pressure hydrocephalus: still a necessary prognostic test?

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Maria Giulia Preti

Objective To assess whether gait, neuropsychological, and multimodal MRI parameters predict short-term symptom reversal after cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH). Methods Thirty patients (79.3 +/- 5.9 years ...

SPRINGER HEIDELBERG2022

Brain structure-function coupling is unique to individuals across multiple frequency bands: a graph signal processing study

Alessandra Griffa, Maria Giulia Preti

The relation between brain functional activity and the underlying structure is complex and varies depending on the specific brain region. Recently, we used graph signal processing to introduce the structural-decoupling index (SDI), a novel metric quantifyi ...

IEEE2022

Connectome embedding in multidimensional graph spaces

Mathieu Mach, Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Maria Giulia Preti, Enrico Amico, Raphaël Pierre Liégeois

Nodal properties are of particular importance when investigating patterns in brain networks. Nodal information is usually studied by comparing a few nodal measurements (up to three), resulting in analyses in three-dimensional spaces, at maximum. We offer a ...

Massachusetts Institute of Technology2024

Transient networks of spatio-temporal connectivity map communication pathways in brain functional systems

Jean-Philippe Thiran, Pierre Vandergheynst, Patric Hagmann, Alessandro Daducci, Alessandra Griffa, Xavier Bresson, Benjamin Ricaud, Kirell Maël Benzi

The study of brain dynamics enables us to characterize the time-varying functional connectivity among distinct neural groups. However, current methods suffer from the absence of structural connectivity information. We propose to integrate infra-slow neural ...

Elsevier2017

Fronto-Temporal Disconnection Within the Presence Hallucination Network in Psychotic Patients With Passivity Experiences

Olaf Blanke, Patric Hagmann, Alessandra Griffa, Giulio Rognini, Roy Salomon, Nathan Quentin Faivre, Jevita Potheegadoo, Eva Blondiaux, Giedre Stripeikyte

Psychosis, characterized by hallucinations and delusions, is a common feature of psychiatric disease, especially schizophrenia. One prominent theory posits that psychosis is driven by abnormal sensorimotor predictions leading to the misattribution of self- ...

2021

Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis

Patric Hagmann, Alessandra Griffa

Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As oxidative stress is also linked to psychosis, it may interact with CT, leading to a more severe clinic ...

National Academy of Sciences2018

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients

Alessandra Griffa

Aim Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophr ...

WILEY2019