Publications de Alessandra Griffa

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The brain is a complex system, composed of multiple neural units interconnected at different spatial and temporal scales. Diffusion MRI allows probing in vivo the anatomical connectivity between different cortical areas through white matter tracts. In para ...

Introduction: Medial Temporal Lobe Epilepsy (mTLE) with hippocampal sclerosis is the most frequent cause of drug-resistant focal epilepsy in adults. These patients suffer from widespread subtle white matter abnormalities and abnormal functional connectivit ...

Brain signatures of functional activity have shown promising results in both decoding brain states, meaning distinguishing between different tasks, and fingerprinting, that is identifying individuals within a large group. Importantly, these brain signature ...

The objective of this study was to examine if patterns of resting-state brain activity and functional connectivity in cortical and subcortical regions in patients with early symptomatic amyotrophic lateral sclerosis (ALS) resemble those of behavioural vari ...

The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

Schizophrenia is a complex psychiatric disorder characterized by disabling symptoms and cognitive deficit. Recent neuroimaging findings suggest that large parts of the brain are affected by the disease, and that the capacity of functional integration betwe ...

Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...

Imaging the connectome in vivo has become feasible through the integration of several rapidly developing fields of science and engineering, namely magnetic resonance imaging and in particular diffusion MRI on one side, image processing and network theory o ...

Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...

The oldest-old subjects represent the fastest growing segment of society and are at high risk for dementia with a prevalence of up to 40%. Lifestyle factors, such as lifelong participation in cognitive and leisure activities, may contribute to individual c ...

Objective To assess whether gait, neuropsychological, and multimodal MRI parameters predict short-term symptom reversal after cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH). Methods Thirty patients (79.3 +/- 5.9 years ...

The relation between brain functional activity and the underlying structure is complex and varies depending on the specific brain region. Recently, we used graph signal processing to introduce the structural-decoupling index (SDI), a novel metric quantifyi ...

Nodal properties are of particular importance when investigating patterns in brain networks. Nodal information is usually studied by comparing a few nodal measurements (up to three), resulting in analyses in three-dimensional spaces, at maximum. We offer a ...

The study of brain dynamics enables us to characterize the time-varying functional connectivity among distinct neural groups. However, current methods suffer from the absence of structural connectivity information. We propose to integrate infra-slow neural ...

Psychosis, characterized by hallucinations and delusions, is a common feature of psychiatric disease, especially schizophrenia. One prominent theory posits that psychosis is driven by abnormal sensorimotor predictions leading to the misattribution of self- ...

Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As oxidative stress is also linked to psychosis, it may interact with CT, leading to a more severe clinic ...

Aim Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophr ...

Lack of awareness of cognitive impairment (i.e. anosognosia) could be a key factor for distinguishing between neuropsychological postCOVID-19 condition phenotypes. In this context, the 2-fold aim of the present study was to (i) establish the prevalence of ...

The maturation of the cortical gray matter (GM) and white matter (WM) are described as sequential processes following multiple, but distinct rules. However, neither the mechanisms driving brain maturation processes, nor the relationship between GM and WM m ...

Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain f ...

Alessandra Griffa

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The topology of structural brain connectivity in diseases and spatio-temporal connectomics

Whole-brain structural connectivity in temporal lobe epilepsy: a Diffusion Spectrum Imaging study

Brain structure-function coupling provides signatures for task decoding and individual fingerprinting

Cortical and subcortical changes in resting-state neuronal activity and connectivity in early symptomatic ALS and advanced frontotemporal dementia

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Characterizing the connectome in schizophrenia with diffusion spectrum imaging

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Structural connectomics in brain diseases

Markers of limbic system damage following SARS-CoV-2 infection

Magnetoencephalography Brain Signatures Relate to Cognition and Cognitive Reserve in the Oldest-Old: The EMIF-AD 90+Study

CSF tap test in idiopathic normal pressure hydrocephalus: still a necessary prognostic test?

Brain structure-function coupling is unique to individuals across multiple frequency bands: a graph signal processing study

Connectome embedding in multidimensional graph spaces

Transient networks of spatio-temporal connectivity map communication pathways in brain functional systems

Fronto-Temporal Disconnection Within the Presence Hallucination Network in Psychotic Patients With Passivity Experiences

Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients

Functional connectivity underlying cognitive and psychiatric symptoms in post-COVID-19 syndrome: is anosognosia a key determinant?

Exploring the role of white matter connectivity in cortex maturation

Additive and interaction effects of working memory and motor sequence training on brain functional connectivity