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Yury Tsybin

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Publications associées (75)

Conformation of Polyalanine and Polyglycine Dications in the Gas Phase: Insight from Ion Mobility Spectrometry and Replica-Exchange Molecular Dynamics

Rodolphe Antoine, Yury Tsybin, Aleksey Vorobyev

The conformation of model Arg(Ala)(4)X(Ala)(4)Lys+2H and Arg(Gly)(4)X(Gly)(4)Lys+2H peptides has been systematically investigated as a function of the central amino acid X through a combined experimental and theoretical approach. Mass spectrome ...

American Chemical Society2010

Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides

Hisham Ben Hamidane, Yury Tsybin, Aleksey Vorobyev

We report on the characteristics of the radical-ion-driven dissociation of a diverse array of beta-amino acids incorporated into alpha-peptides, as probed by tandem electron-capture and electron-transfer dissociation (ECD/ETD) mass spectrometry. The report ...

2010

Thermal Decomposition of C60H18

Yury Tsybin

Products of thermal dehydrogenation of C60H18 (which mainly occurs at 450-600 degrees C) were studied by XRD, Raman, IR and mass spectrometry. IR spectra indicate that dehydrogenation resulted in partial recovery of pristine C-60. XRD data indicate that th ...

2009

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability

Hisham Ben Hamidane, Yury Tsybin, Aleksey Vorobyev

We present mechanistic studies aimed at improving the understanding of the product ion formation rules in electron capture dissociation (ECD) of peptides and proteins in Fourier transform ion cyclotron resonance mass spectrometry. In particular, we attempt ...

Springer-Verlag2009

Periodic Sequence Distribution of Product Ion Abundances in Electron Capture Dissociation of Amphipathic Peptides and Proteins

Hisham Ben Hamidane, Yury Tsybin

The rules for product ion formation in electron capture dissociation (ECD) mass spectrometry of peptides and proteins remain unclear. Random backbone cleavage probability and the nonspecific nature of ECD toward amino acid sequence have been reported, cont ...

Springer-Verlag2009

Electron Capture and Transfer Dissociation: Peptide Structure Analysis at Different Ion Internal Energy Levels

Hisham Ben Hamidane, Marc Moniatte, Diego Chiappe, Yury Tsybin, Aleksey Vorobyev

We decoupled electron-transfer dissociation (ETD) and collision-induced dissociation of charge-reduced species (CRCID) events to probe the lifetimes of intermediate radical species in ETD-based ion trap tandem mass spectrometry of peptides. Short-lived int ...

Springer-Verlag2009

Amide-I relaxation-induced hydrogen bond distortion: an intermediate in electron capture dissociation mass spectrometry of alpha-helical peptides?

Yury Tsybin

2008

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

Hisham Ben Hamidane, Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been used to probe the interaction of the anticancer drug cisplatin with oligonucleotides. The binding kinetics, the nature of the adducts formed, and the location of the binding s ...

2008

Synthesis and structural characterization of C70-H38

Yury Tsybin

Wiley-VCH Verlag GmbH2008

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Paul Joseph Dyson, Céline Rita Duhot, Yury Tsybin, Christian Hartinger, Angela Casini

The interactions of the ruthenium(II) complex Ru(η6-p-cymene)(pta)Cl2 (RAPTA-C), an effective anticancer and antimetastatic agent, with biol. nucleophiles are important with respect to its mechanism of action, for example, the reaction with glutathione (GS ...

2008

Electron capture dissociation implementation progress in Fourier transform ion cyclotron resonance mass spectrometry

Yury Tsybin

Springer-Verlag2008

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

A proof-of-principle study on the application of a top-down electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric approach for characterization of the primary binding sites of the platinum anticancer agents cisplatin, transpl ...

2008

Ion activation in electron capture dissociation to distinguish between N-terminal and C-terminal product ions

Yury Tsybin

2007

Identification of Single and Double Sites of Phosphorylation by ECD FT-ICR/MS in Peptides Related to the Phosphorylation Site Domain of the Myristoylated Alanine-rich C Kinase Protein

Yury Tsybin

2007

Composition of hydrofullerene mixtures produced by C60 reaction with hydrogen gas revealed by high-resolution mass spectrometry

Yury Tsybin, Andreas Züttel, Philippe Mauron

2005

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