Publications de Tamar Kohn | EPFL Graph Search

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Despite the widespread use of UV254 irradiation and solar disinfection for water treatment, little is known about the photochemical pathways that lead to virus inactivation by these treatments. The goal of this study was to identify reactions that occur in ...

Ferrate [Fe(VI); FeO42-] is an emerging oxidizing agent capable of controlling chemical and microbial water contaminants. Here, inactivation of MS2 coliphage by Fe(VI) was examined. The inactivation kinetics observed in individual batch experiments was wel ...

Influenza A virus (IAV) spreads through exhaled aerosol particles and larger droplets. Estimating the stability of IAV is challenging and depends on factors such as the respiratory matrix and drying kinetics. Here, we combine kinetic experiments on millime ...

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

Climate changes influence lake hydrodynamics and radiation levels and thus may affect the fate and transport of waterborne pathogens in lakes. This study examines the impact of climate change on the fate, transport, and associated risks of four waterborne ...

This study discusses the occurrence and environmental risk associated with a micropollutant plume originating from the direct discharge of treated wastewater into the Vidy Bay of Lake Geneva, Switzerland. The temporal variations and spatial extent of the p ...

Sanitizing human and animal waste (e.g., urine, fecal sludge or grey water) is a critical step in reducing the spread of disease and ensuring microbially safe reuse of waste materials. Viruses are particularly persistent pathogens and can be transmitted th ...

Oxidative processes are often harnessed as tools for pathogen disinfection. Although the pathways responsible for bacterial inactivation with various biocides are fairly well understood, virus inactivation mechanisms are often contradictory or equivocal. I ...

Attempts to develop quantitative structure-activity relationships (QSARs) for reductive dehalogenation have been hindered by the unavailability of high quality predictor variables, have included relatively few compounds, and on occasion have relied on data ...

Respiratory viruses, including influenza virus and SARS-CoV-2, are transmitted by the airborne route. Air filtration and ventilation mechanically reduce the concentration of airborne viruses and are necessary tools for disease mitigation. However, they ign ...

Viruses represent major disease transmitting agents carried by human excreta and animal manure. Understanding virus inactivation is therefore essential in preventing microbial spread due to inadequate treatment of these materials. Here, we investigated the ...

Waterborne viruses are responsible for numerous diseases and are abundant in aquatic systems. Understanding the fate of viruses in natural systems has important implications for human health. This research quantifies the uptake of bacteriophage T4 and the ...

Health-relevant microorganisms present in natural surface waters and engineered treatment systems that are exposed to sunlight can be inactivated by a complex set of interacting mechanisms. The net impact of sunlight depends on the solar spectral irradianc ...

Enteroviruses are common agents of infectious disease that are spread by the fecal-oral route. They are readily inactivated by mild heat, which causes the viral capsid to disintegrate or undergo conformational change. While beneficial for the thermal treat ...

The COVID-19 pandemic has accelerated the development and adoption of wastewater-based epidemiology. Wastewater samples can provide genomic information for detecting and assessing the spread of SARS-CoV-2 variants in communities and for estimating importan ...

UV disinfection of viruses frequently leads to tailing after an initial exponential decay. Aggregation, light shielding, recombination or resistant virus sub-populations were proposed as explanations; however, none of these options has conclusively been de ...

Human adenoviruses (HAdV) are important pathogens in both industrialized and developing nations. HAdV has been shown to be relatively resistant to monochromatic UVC. Polychromatic UVC, in contrast, is a more effective means of disinfection, presumably due ...

Health risks posed by waterborne viruses are difficult to assess because it is tedious or impossible to determine the infectivity of many viruses. Recent studies hypothesized that quantitative PCR (qPCR) could selectively quantify infective viruses if prec ...

MS2 coliphage, a surrogate for human enteric viruses, is inactivated by singlet oxygen (1O2) produced via sunlight-mediated excitation of natural organic matter (NOM) in surface waters. The 1O2 concentration within a NOM macromolecule or supramolecular ass ...

Common water disinfectants like chlorine have been reported to select for resistant viruses, yet little attention has been devoted to characterizing disinfection resistance. Here, we investigated the resistance of MS2 coliphage to inactivation by chlorine ...

Tamar Kohn

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Oxidation of Virus Proteins during UV(254) and Singlet Oxygen Mediated Inactivation

Inactivation of bacteriophage MS2 with potassium ferrate(VI)

Salt Supersaturation as an Accelerator of Influenza A Virus Inactivation in 1 μL Droplets

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Waterborne Virus Transport and Risk Assessment in Lake Geneva Under Climate Change

Spatial and temporal presence of a wastewater-derived micropollutant plume in Lake Geneva

Ammonia as an in-situ sanitizer: inactivation kinetics and mechanisms of the ssRNA virus MS2 by NH3

Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity

Reactivity of Alkyl Polyhalides toward Granular Iron: Development of QSARs and Reactivity Cross Correlations for Reductive Dehalogenation

Expiratory Aerosol pH: The Overlooked Driver of Airborne Virus Inactivation

Virus inactivation in stored human urine, sludge and animal manure under typical conditions of storage or mesophilic anaerobic digestion

Viral Transfer and Inactivation through Zooplankton Trophic Interactions

Sunlight-mediated inactivation of health-relevant microorganisms in water: A review of mechanisms and modeling approaches

Salt enhances the thermostability of enteroviruses by stabilizing capsid protein interfaces

Estimated transmission dynamics of SARS-CoV-2 variants from wastewater are unbiased and robust to differential shedding

Inactivation and tailing during UV254 disinfection of viruses: contributions of viral aggregation, light shielding within viral aggregates and recombination

Mechanisms of Human Adenovirus Inactivation by Sunlight and UVC Light as Examined by Quantitative PCR and Quantitative Proteomics

Quantitative PCR for determining the infectivity of bacteriophage MS2 upon inactivation by heat, UVB and singlet oxygen: advantages and limitations of an enzymatic treatment to reduce false-positive results

Association with Natural Organic Matter Enhances the Sunlight-Mediated Inactivation of MS2 Coliphage by Singlet Oxygen

Genetic, structural and phenotypic properties of MS2 coliphage with resistance to ClO2 disinfection