Aurélien Bornet

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Publications associées (51)

Boosting Dissolution Dynamic Nuclear Polarization by Cross Polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Angel Joaquin Perez Linde

The efficiency of dissolution dynamic nuclear polarization can be boosted by Hartmann-Hahn cross polarization at temperatures near 1.2 K. This enables high throughput of hyperpolarized solutions with substantial gains in buildup times and polarization leve ...

Amer Chemical Soc2013

Method for the nmr based determination of the affinity of drugs for a target protein

Geoffrey Bodenhausen, Aurélien Bornet, Nicola Salvi, Roberto Buratto

The document relates to a method for the determination of the binding properties of at least one first chemical compound to at least one second chemical compound between a free essentially dissociated state and a bound essentially associated state by using ...

2013

Method and device for rapid dnp

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high gamma nuclei with a short T1, - a polarizing agent with a broad EPR line, and low gamma nuclei with a l ...

2013

Boosting the Sensitivity of Ligand-Protein Screening by NMR of Long-Lived States

Geoffrey Bodenhausen, Christian Heinis, Aurélien Bornet, Simone Ulzega, Alessandro Angelini, Nicola Salvi, Inmaculada Rentero Rebollo, Roberto Buratto

A new NMR method for the study of ligand protein interactions exploits the unusual lifetimes of long-lived states (LLSs). The new method provides better contrast between bound and free ligands and requires a protein-ligand ratio ca. 25 times lower than for ...

2012

Dynamic Nuclear Polarization and Other Magnetic Ideas at EPFL

Geoffrey Bodenhausen, Martial Rey, Sami Jannin, Aurélien Bornet, Jonas Milani, Simone Ulzega, Pascal Miéville, Marc Anthony Caporini, Nicola Salvi, Diego Carnevale, Roberto Buratto, Srinivas Chinthalapalli, Shutao Wang, Daniele Mammoli, Angel Joaquin Perez Linde

Although nuclear magnetic resonance (NMR) can provide a wealth of information, it often suffers from a lack of sensitivity. Dynamic Nuclear Polarization (DNP) provides a way to increase the polarization and hence the signal intensities in NMR spectra by tr ...

2012

Ultrahigh-Resolution Magnetic Resonance in Inhomogeneous Magnetic Fields: Two-Dimensional Long-Lived-Coherence Correlation Spectroscopy

Geoffrey Bodenhausen, Sami Jannin, Riddhiman Sarkar, Aurélien Bornet, Srinivas Chinthalapalli

A half-century quest for improving resolution in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) has enabled the study of molecular structures, biological interactions, and fine details of anatomy. This progress largely relied on the ...

2012

Cross Polarization for Dissolution Dynamic Nuclear Polarization Experiments at Readily Accessible Temperatures 1.2 < T < 4.2 K

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Cross polarization can provide significant enhancements with respect to direct polarization of low-gamma nuclei such as C-13. Substantial gains in sample throughput (shorter polarization times) can be achieved by exploiting shorter build-up times tau(DNP)( ...

Springer Verlag2012

Low-temperature cross polarization in view of enhancing dissolution Dynamic Nuclear Polarization in NMR

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Dynamic Nuclear Polarization (DNP) induced by saturation of ESR transitions of TEMPO at 1.2 K and 3.35 T is characterized by build-up rates that are typically 5 times faster for protons than for the carboxylic carbon-13 in acetate. We show that cross polar ...

Elsevier2011

Ultra High-Resolution NMR: Sustained Induction Decays of Long-Lived Coherences

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Long-lived coherences (LLCs) in homonuclear pairs of chemically inequivalent spins can be excited and sustained during protracted radio frequency irradiation periods that alternate with brief windows for signal observation. Fourier transformation of the su ...

2011

Three-field NMR to preserve hyperpolarized proton magnetization as long-lived states in moderate magnetic fields

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

This communication describes a three-field experiment where inequivalent scalar coupled spin pairs are hyperpolarized at 3.35 T and 1.2 K by dynamic nuclear polarization (DNP), rapidly transferred to high field (7 T) to prepare a suitable initial condition ...

Elsevier2011

Long-Lived States to Monitor Protein Unfolding by Proton NMR

Geoffrey Bodenhausen, Riddhiman Sarkar, Aurélien Bornet, Paul Romeo Vasos, Puneet Ahuja

The relaxation of long-lived states (LLS) corresponds to the slow return to statistical thermal equilibrium between symmetric and antisymmetric proton spin states. This process is remarkably sensitive to the presence of external spins and can be used to ob ...

Wiley-Blackwell2011

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