Publications de Rajnish Ranjan

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Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

The neocortex is one of the most evolved and complex region of the brain. For more than a century scientists have been curious about the neocortex, to identify the anatomical blueprint of its cellular organization and to understand its role in higher brain ...

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison o ...

Rajnish Ranjan

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Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Engineering Neuron Models : from Ion Channels to Electrical Behavior

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Reconstruction and Simulation of Neocortical Microcircuitry

Mapping the function of neuronal ion channels in model and experiment

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep