Publications de Rajnish Ranjan

Publications associées (8)

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Weina Ji, Henry Markram, Felix Schürmann, Daniel Keller, Eilif Benjamin Muller, Michael Reimann, Werner Alfons Hilda Van Geit, Srikanth Ramaswamy, Matthias Wolf, James Gonzalo King, Alexis Arnaudon, András Ecker, Rajnish Ranjan, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Judit Planas Carbonell, Giuseppe Chindemi, Michael Emiel Gevaert, Christian Andreas Rössert, Fernando Joaquim Leite Pereira, Omar Awile, Mustafa Anil Tuncel, Daniela Egas Santander, James Bryden Isbister, Natali Barros Zulaica, Samuel Lieven D. Lapere, Sirio Bolaños Puchet, Maria Reva, Genrich Ivaska, Tanguy Pierre Louis Damart, Darshan Mandge, Joni Henrikki Herttuainen, Christoph Pokorny, Elvis Boci, Vishal Sood, Thomas Brice Delemontex, Aleksandra Zuzanna Teska, Polina Litvak, Alexander Dietz, Jorge Blanco Alonso, Gianluca Ficarelli

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

Engineering Neuron Models : from Ion Channels to Electrical Behavior

Rajnish Ranjan

The neocortex is one of the most evolved and complex region of the brain. For more than a century scientists have been curious about the neocortex, to identify the anatomical blueprint of its cellular organization and to understand its role in higher brain ...

EPFL2011

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Henry Markram, Rajnish Ranjan, Emmanuelle Logette, Enrico Scantamburlo, Michela Marani, Valérie Buchillier, Mirjia Herzog

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

2019

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Werner Alfons Hilda Van Geit, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Julian Charles Shillcock, Ying Shi, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Nicolas Antille, Jeffrey Christopher Muller, Ahmet Bilgili

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

Frontiers Research Foundation2015

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Felix Schürmann, Eilif Benjamin Muller, Sean Lewis Hill, Idan Segev, Srikanth Ramaswamy, Michael Reimann, Daniel Keller, Thomas Heinis, Werner Alfons Hilda Van Geit, Rodrigo de Campos Perin, Marwan Muhammad Ahmed Abdellah, James Gonzalo King, Lida Kanari, Farhan Tauheed, Julian Charles Shillcock, Pramod Shivaji Kumbhar, Gilad Silberberg, Ying Shi, Vincent Delattre, Jean-Denis Georges Emile Courcol, Rajnish Ranjan, Juan Bautista Hernando Vieites, Stefan Eilemann, Michael Emiel Gevaert, Giuseppe Chindemi, Jean-Vincent Le Bé, Julie Meystre, Taylor Howard Newton, Max Christian Nolte, Nicolas Antille, Georges Khazen, Sébastien Lasserre, Jean Pierre Ghobril, Jeffrey Christopher Muller, Aleksandr Ovcharenko, Shruti Muralidhar, Ahmet Bilgili, Daniel Nachbaur

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Mapping the function of neuronal ion channels in model and experiment

Rajnish Ranjan, Alexander Kevin Seeholzer, Tim Vogels, William Francis Podlaski

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison o ...

Elife Sciences Publications Ltd2017

Ready-to-Record Cells for Kinetic Screening of VGICs

Rajnish Ranjan, Emmanuelle Logette

Voltage-gated ion channels (VGICs) are integral membrane proteins crucial for transmitting electrical signals in excitable cells. Understanding the kinetics of these ion channels requires conducting patch-clamp experiments using genetically modified cell l ...

2024

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Henry Markram, Sean Lewis Hill, Rodrigo de Campos Perin, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Werner Alfons Hilda Van Geit, Matthias Wolf, James Gonzalo King, Ying Shi, András Ecker, Rajnish Ranjan, Jean-Denis Georges Emile Courcol, Pramod Shivaji Kumbhar, Christian O'Reilly, Michael Emiel Gevaert, Fernando Joaquim Leite Pereira, Mustafa Anil Tuncel, Nadir Roman Guerrero, Elisabetta Iavarone, Mohameth François Sy, Benoît Jean-Albert Coste, Ioannis Magkanaris, Cyrille Pierre Henri Favreau, Genrich Ivaska, Anna-Kristin Kaufmann, Joni Henrikki Herttuainen, Grigori Chevtchenko, Samuel Claude Kerrien, Jayakrishnan Harikrishnavilas Raveendran Nair, Adrien Christian Fleury, Marine Laure Bertschy, Fabien Petitjean, Liviu Soltuzu, Alexander Désiré Ulbrich, Polina Litvak, Vignayanandam Ravindernath Muddapu, Patrycja Lurie

2023