Anne Grapin-Botton

Cette personne n’est plus à l’EPFL

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Publications associées (31)

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Theo Lasser, Martin Villiger, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Joan Goulley

Aims/hypothesis Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta ...

Springer Verlag2009

Role of Neurogenin3 in the migration of pancreatic endocrine cells

Anne Grapin-Botton, Mathieu Gouzi, Nancy Thompson

Elsevier2009

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

Anne Grapin-Botton

BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of i ...

Public Library of Science2009

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types

Friedrich Beermann, Anne Grapin-Botton

All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated tran ...

Cell Press - Elsevier2007

The genetic programme of pancreatic β-cells: basic science for the development of β-cell therapy. Workshop on Programming Pancreatic β-Cells

Anne Grapin-Botton

2007

Pancreas development and cancer - Wnt/beta-catenin at issue

Anne Grapin-Botton

beta-catenin and Adenomatous poliposis coli (APC) have been implicated in non-ductal pancreatic cancers. As for many other organs, several recent publications show that beta-catenin and more largely the Wnt pathway appear to function at the level of pancre ...

2006

FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo

Anne Grapin-Botton

At the end of gastrulation in avians and mammals, the endoderm germ layer is an undetermined sheet of cells. Over the next 24-48 h, endoderm forms a primitive tube and becomes regionally specified along the anterior-posterior axis. Fgf4 is expressed in gas ...

2006

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

Anne Grapin-Botton, Jörg Hülsken

Mutations and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown [1-4]. This article reports a comprehe ...

2005

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Anne Grapin-Botton

This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stage ...

2005

Ductal cells of the pancreas

Anne Grapin-Botton

Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum. In addition, these cells secrete bicarbonate that neutralizes stomach acidity. During development, epi ...

2005

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

Anne Grapin-Botton

The mechanisms by which the epithelium of the digestive tract and its associated glands are specified are largely unknown. One clue is that several transcription factors are expressed in specific regions of the endoderm prior to and during organogenesis. P ...

2001

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