Anne Grapin-Botton

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Related publications (31)

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REST represses a subset of the pancreatic endocrine differentiation program

Anne Grapin-Botton, Yung Hae Kim

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing panc ...

Academic Press Inc Elsevier Science2015

The genetic programme of pancreatic β-cells: basic science for the development of β-cell therapy. Workshop on Programming Pancreatic β-Cells

Anne Grapin-Botton

2007

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

Anne Grapin-Botton

Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systema ...

Company Of Biologists Ltd2012

RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors

Emilie Gesina, Philipp Bucher, Anne Grapin-Botton

Pancreas development is initiated by the specification and expansion of a small group of endodermal cells. Several transcription factors are crucial for progenitor maintenance and expansion, but their interactions and the downstream targets mediating their ...

American Society for Microbiology2012

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Dimitri Nestor Alice Van De Ville, Theo Lasser, Anthony Christopher Davison, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Corinne Berclaz, Erica Martin-Williams, Joan Goulley

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Anne Grapin-Botton

This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stage ...

2005

Concise Reviews: In Vitro-Produced Pancreas Organogenesis Models in Three Dimensions: Self-Organization From Few Stem Cells or Progenitors

Anne Grapin-Botton, Chiara Greggio, Filippo De Franceschi

Three-dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of ce ...

Wiley-Blackwell2015

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Jacques Rougemont, Daniel Constam, Anne Grapin-Botton, Joan Goulley, Yung Hae Kim

In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads to left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed i ...

Company Of Biologists Ltd2015

Pancreas development and cancer - Wnt/beta-catenin at issue

Anne Grapin-Botton

beta-catenin and Adenomatous poliposis coli (APC) have been implicated in non-ductal pancreatic cancers. As for many other organs, several recent publications show that beta-catenin and more largely the Wnt pathway appear to function at the level of pancre ...

2006

Patterning and shaping the endoderm in vivo and in culture

Anne Grapin-Botton, Marine Marie Kraus

The definitive endoderm (DE) was first defined as the innermost germ layer found in all metazoan embryos. During development, it gives rise to a vast array of specialized epithelial cell types lining the respiratory and digestive systems, and contributes t ...

Elsevier2012

Role of Neurogenin3 in the migration of pancreatic endocrine cells

Anne Grapin-Botton

Elsevier2009