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Pierre Gönczy

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Publications associées (110)

Paternally contributed centrioles exhibit exceptional persistence in C-elegans embryos

Pierre Gönczy, Lukas von Tobel, Fernando Romero Balestra

Inst Biochemistry & Cell Biology2015

Cortical Dynein Powered by Polarized Actomyosin Contractions and Pronuclear Dynein Separate Centrosomes

Pierre Gönczy, Alessandro De Simone

Cell Press2015

A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family

Pierre Gönczy

Asymmetric cell division is essential for normal human brain development. Mutations in several genes encoding centrosomal proteins that participate in accurate cell division have been reported to cause autosomal recessive primary microcephaly (MCPH). By ho ...

Oxford University Press2014

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Pierre Gönczy, Coralie Busso, Sachin Kotak

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gai1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper s ...

2014

Correlative multicolor 3D SIM and STORM microscopy

Mathias Fournier, Pierre Gönczy, Virginie Hamel, Arne Seitz, Isabelle Fluckiger, Paul Guichard, Romain Guiet

Within the last decade, super-resolution methods that surpass the diffraction limit of light microscopy have provided invaluable insight into a variety of biological questions. Each of these approaches has inherent advantages and limitations, such that the ...

Optical Soc Amer2014

Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos

Pierre Gönczy, Kalyani Thyagarajan, Sylvain Träger, Alessandro De Simone

Regulation of centrosome and spindle positioning is crucial for spatial cell division control. The one-cell Caenorhabditis elegans embryo has proven attractive for dissecting the mechanisms underlying centrosome and spindle positioning in a metazoan organi ...

Company Of Biologists Ltd2014

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Pierre Gönczy, Fernando Romero Balestra

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key ...

Cell Press2014

NuMA phosphorylation dictates dynein-dependent spindle positioning

Pierre Gönczy, Sachin Kotak

Landes Bioscience2014

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos

Pierre Gönczy

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps during earlydevelopment. In this review, we discuss processes that set up the embryonic axes, with an emphasis onpolarity establishment and asymmetric division. W ...

WormBook2014

NuMA links the mitotic spindle with plasma membrane lipids

Pierre Gönczy, Coralie Busso, Sachin Kotak

Amer Soc Cell Biology2014

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells

Romain Wyss, Pierre Gönczy, Debora Keller, Suliana Manley

SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS-6 ...

Rockefeller University Press2014

Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development

Pierre Gönczy, Christian Gentili

Nature Publishing Group2014

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans

Simon Blanchoud, Graham Knott, Pierre Gönczy, Tamara Mikeladze-Dvali, Lukas von Tobel

Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sp ...

Public Library of Science2014

Mechanisms of spindle positioning: cortical force generators in the limelight

Pierre Gönczy, Sachin Kotak

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus plays a crucial role in the partitioning of fate determinants and the disposition of daughter cells in a tissue. Converging evidence indicates that spindle positioning ...

2013

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

Pierre Gönczy, Petr Strnad, Isabelle Fluckiger, Fernando Romero Balestra

Centrioles are essential for forming cilia, flagella, and centrosomes and are thus critical for a range of fundamental cellular processes. Despite their importance, the mechanisms governing centriole biogenesis remain incompletely understood. We performed ...

Cell Press - Elsevier2013

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Pierre Gönczy, Coralie Busso, Sachin Kotak

Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

Nature Publishing Group2013

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

Kai Johnsson, Luc Reymond, Pierre Gönczy, Grazvydas Lukinavicius, Keitaro Umezawa

The centrosome functions as the main microtubule-organizing center of animal cells and is crucial for several fundamental cellular processes [1]. Abnormalities in centrosome number and composition correlate with tumor progression [2, 3] and other diseases ...

Elsevier2013

Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry

Pierre Gönczy, Virginie Hamel, Isabelle Fluckiger, Paul Guichard, Georgios Hatzopoulos

Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas ...

2013

Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry

Aitana Neves da Silva, Pierre Gönczy, Davide Demurtas, Isabelle Fluckiger, Paul Guichard, Norbert Majubu

Centrioles are cylindrical microtubule-based structures whose assembly is critical for the formation of cilia, flagella, and centrosomes. The centriole proximal region harbors a cartwheel that dictates the 9-fold symmetry of centrioles. Although the cartwh ...

2013

Simple buffers for 3D STORM microscopy

Pierre Gönczy, Debora Keller, Suliana Manley, Vinoth Edal Joseph Sundar Rajan

3D STORM is one of the leading methods for super-resolution imaging, with resolution down to 10 nm in the lateral direction, and 30-50 nm in the axial direction. However, there is one important requirement to perform this type of imaging: making dye molecu ...

Optical Soc Amer2013

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