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Rolf Gruetter

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Publications associées (418)

Minimization of Nyquist ghosting for fMRI at Ultra-High Fields Based on a ‘negative Read-Out Gradient’

Rolf Gruetter, Hongxia Lei, Nathalie Just, Wietske Van der Zwaag, José Pedro Rebelo Ferreira Marques

2008

Editing through multiple bonds: Threonine detection

Rolf Gruetter

In in vivo H-1 spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of eithe ...

Wiley-Blackwell2008

A Continuous Nyquist Ghost Correction for EPI-based fMRI

Rolf Gruetter, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques

2008

Precision of metabolite concentrations obtained by LCModel as a function of the signal-to-noise ratio in rodent brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin

2007

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Arnaud Comment, Jacques Van Der Klink, Rolf Gruetter, Sami Jannin, Fiodar Kurdzesau

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

2007

Glucose and glycogen content in rat hypothalamus at euglycemia and hypoglycemia

Rolf Gruetter, Hanne Frenkel, Hongxia Lei, Carole Poitry-Yamate

Wiley-Blackwell2007

Direct validation of in vivo localized 13C MRS measurements of brain glycogen

Rolf Gruetter, Hongxia Lei

With the use of localized 13C MRS in conjunction with [1-(13)C]-D-glucose infusion, it is possible to study brain glycogen metabolism in vivo. The purpose of this study was to validate in vivo 13C MRS measurements by comparing them with results from a stan ...

Wiley-Blackwell2007

Short-echo-time 1H MRS of the mouse lacking brain-specific glutamate-dehydrogenase

Rolf Gruetter

2007

Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions

Sabrina Laus, Rolf Gruetter, Ruud van Heeswijk

The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM ...

Elsevier2007

T2 relaxation of coupled spin resonances of cerebral metabolites in rat brain at 9.4 T

Rolf Gruetter, Giulio Gambarota, Lijing Xin

2007

Mathematical modeling of (13)C label incorporation of the TCA cycle: the concept of composite precursor function

Rolf Gruetter

A novel approach for the mathematical modeling of (13)C label incorporation into amino acids via the TCA cycle that eliminates the explicit calculation of the labeling of the TCA cycle intermediates is described, resulting in one differential equation per ...

Wiley-Blackwell2007

Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex

Rolf Gruetter

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in th ...

2007

Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

Rolf Gruetter

In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ...

Wiley-Blackwell2007

13C-edited 1H NMR Spectroscopy with Selective Resonance Suppression Using Asymmetric Adiabatic RF Pulses

Rolf Gruetter, Lijing Xin, Hanne Frenkel

2007

Energy balance impairment in mice with Central Nervous System specific glutamate dehydrogenase knockout

Rolf Gruetter

Federation of American Society of Experimental Biology2007

Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition

Rolf Gruetter, Giulio Gambarota, Hanne Frenkel

We developed a short-echo-time (TE) sequence for proton localized spectroscopy by combining a 1D add-subtract scheme with a doubly slice-selective spin-echo (SE) sequence. The sequence preserves the full magnetization available from the selected volume of ...

Wiley-Blackwell2006

Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study

Rolf Gruetter, Hongxia Lei

While chronic hypoglycaemia has been reported to increase unidirectional glucose transport across the blood-brain barrier (BBB) and to increase GLUT1 expression at the endothelium, the effect on steady-state brain d-glucose and brain glycogen content is cu ...

Wiley-Blackwell2006

Biochemical quantification of total brain glycogen concentration in rats under different glycemic states

Rolf Gruetter

All 13C NMR studies of brain glycogen to date relied on observing the incorporation of 13C label into glycogen, and thus interpretation was potentially affected by changes in 13C label turnover rates. The goal of this study was to quantify total brain glyc ...

Elsevier2006

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