Despite obvious improvements in spectral resolution at high magnetic field, the detection of C-13 labeling by H-1-[C-13] NMR spectroscopy remains hampered by spectral overlap, such as in the spectral region of H-1 resonances bound to C3 of glutamate (Glu) ...

Wiley-Blackwell2009

Glutamine synthesis rate in the hyperammonaemic rat brain using simultaneous localized in vivo H-1 and N-15 MRS

Yves Pilloud, Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu

Nature Publishing Group2009

Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu

Reliable quantification of the macromolecule signals in short echo-time H-1 MRS spectra is particularly important at high magnetic fields for an accurate quantification of metabolite concentrations (the neurochemical profile) due to effectively increased s ...

2009

Glycine Tissue Level in Medulla Oblongata Measured in vivo with 1H MRS at 9.4 T in Rat Brain

Rolf Gruetter, Giulio Gambarota, Lijing Xin, João Miguel das Neves Duarte

2009

White matter changes in Lipopolysaccharide treated fetal sheep measured by high-field Diffusion Tensor Imaging

Rolf Gruetter, Yohan Van de Looij

2009

Minimization of Nyquist ghosting for echo-planar imaging at ultra-high fields based on a "negative readout gradient" strategy

Rolf Gruetter, Hongxia Lei, Nathalie Just, Wietske Van der Zwaag, Tobias Kober, José Pedro Rebelo Ferreira Marques

Purpose: To improve the traditional Nyquist ghost correction approach in echo planar imaging (EPI) at high fields, via schemes based on the reversal of the EPI readout gradient polarity for every other volume throughout a functional magnetic resonance imag ...

Wiley-Blackwell2009

Effect of long-term caffeine consumption on glucose transport and osmolarity alterations in the hippocampus of STZ-induced and Goto-Kakizaki diabetic rats: in vivo 1H MRS study at 9.4 T

Rolf Gruetter, João Miguel das Neves Duarte

2009

MRI/MRS of ischemic evolution in mouse brain at 14.1 Tesla

Rolf Gruetter, Hongxia Lei

Wiley-Blackwell2009

Neuroprotective role of lactate after cerebral ischemia

Pierre Magistretti, Rolf Gruetter, Hongxia Lei, Jonathan Thevenet

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...

2009

Time-resolved measurement of rat brain glycogen absolute concentration in vivo

Sabrina Laus, Rolf Gruetter, Ruud van Heeswijk, Lijing Xin, Hanne Frenkel, Hongxia Lei

Wiley-Blackwell2009

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Arnaud Comment, Jacques Van Der Klink, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

Pierre Magistretti, Bernard Lanz, Rolf Gruetter, Jean-Marie Petit, Hanne Frenkel

Although glycogen (Glyc) is the main carbohydrate storage component, the role of Glyc in the brain during prolonged wakefulness is not clear. The aim of this study was to determine brain Glyc concentration ([]) and turnover time (tau) in euglycemic conscio ...

Elsevier2009

Adaptive FID-navigators for respiration monitoring in multi-slice fMRI applications

Reto Meuli, Rolf Gruetter, Wietske Van der Zwaag, Gunnar Krüger, Tobias Kober, José Pedro Rebelo Ferreira Marques

Functional magnetic resonance imaging (fMRI) measures activation-induced signal changes by means of the blood-oxygenation-level-depended (BOLD) contrast. Since signal changes are typically only 1-3%, the method is intrinsically sensitive to all signal inst ...

2008

Improved Spectral Dispersion in Proton MR Spectroscopy of the Neurochemical Profile in the Rat Brain at 14.1 Tesla

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu

2008

High-Quality MR Spectroscopy of the Human Brain with Full Signal Intensity at Echo Times Below 6 ms on a Clinical Platform at 3T and 7T

Rolf Gruetter, Giulio Gambarota, Gunnar Krüger

2008

In Vivo Detection of Hyperpolarized 15N Choline in the Rat

Arnaud Comment, Chiara Perazzolo, Rolf Gruetter, Sami Jannin, Ruud van Heeswijk, Fiodar Kurdzesau, Cristina Ramona Cudalbu

2008

1H NMR T1 Relaxation Times of the Neurochemical Profiles in Rat Brain at 14.1T

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu

2008

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