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Melody Swartz

Cette personne n’est plus à l’EPFL

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Publications associées (136)

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts

Boris Hinz, Melody Swartz, Adrian Chung-Kai Shieh

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how ...

American Association for Cancer Research2011

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Melody Swartz, Ulrike Haessler, Mingming Wu, Marco Pisano

Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is important for adaptive immunity, and is regulated by gradients of CCL19 and CCL21, ligands for CCR7. Despite the importance of DC chemotaxis, it is not well understood ho ...

National Academy of Sciences2011

Regulation of tumor invasion by interstitial fluid flow

Melody Swartz, Adrian Chung-Kai Shieh

The importance of the tumor microenvironment in cancer progression is undisputed, yet the significance of biophysical forces in the microenvironment remains poorly understood. Interstitial fluid flow is a nearly ubiquitous and physiologically relevant biop ...

2011

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Alice Anna Tomei, Jackson Eby, Karen Dane

By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm are efficiently transported through ly ...

Elsevier2011

Block copolymers and uses thereof

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in eac ...

2010

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy, Eleonora Simeoni

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21

Melody Swartz, Alice Anna Tomei, Iraklis Kourtis

Tumor manipulation of host immunity is important for tumor survival and invasion. Many cancers secrete CCL21, a chemoattractant for various leukocytes and lymphoid tissue inducer cells, which drive lymphoid neogenesis. CCL21 expression by melanoma tumors i ...

American Association for the Advancement of Science2010

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema

Melody Swartz, Joseph Rutkowski

Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mo ...

American Society for Investigative Pathology2010

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications

Jan Overney, Melody Swartz, Carmen Bonvin, James Brandon Dixon, Adrian Chung-Kai Shieh

Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current models that incorporate interstitial flow and that are suitable fo ...

Wiley-Blackwell2010

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Melody Swartz, Joseph Rutkowski, Dimana Miteva, James Brandon Dixon, Witold Waldemar Kilarski

RATIONALE: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is important for both adaptive immunity and maintenance of tolerance to self-antigens. Lymphatic drainage can change rapidly and dramatically on tissue injury or infl ...

American Heart Association2010

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

Melody Swartz

Interstitial flow is an important regulator of various cell behaviors both in vitro and in vivo, yet the forces that fluid flow imposes on cells embedded in a 3D extracellular matrix (ECM), and the effects of matrix architecture on those forces, are not we ...

Elsevier2010

Engineered fibrin-binding VEGF-C variant promotes lymphangiogenesis in vitro and in vivo in a dermal wound healing model

Jeffrey Alan Hubbell, Melody Swartz, Miriella Carmela Pasquier, Witold Waldemar Kilarski, Esra Güç

2009

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium: An early indicator of injury and inflammation?

Melody Swartz, Joseph Rutkowski, Dimana Miteva, James Brandon Dixon, Witold Waldemar Kilarski

Karger2009

In Vitro Models of Inhalation Toxicity and Disease The Report of a FRAME Workshop

Melody Swartz

2009

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Melody Swartz, Sandeep Raghunathan, James Brandon Dixon

Lacteals are the entry point of all dietary lipids into the circulation, yet little is known about the active regulation of lipid uptake by these lymphatic vessels, and there lacks in vitro models to study the lacteal-enterocyte interface. We describe an i ...

Wiley-Blackwell2009

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

Melody Swartz, Alice Anna Tomei

In the paracortex of the lymph node (LN), T zone fibroblastic reticular cells (TRCs) orchestrate an immune response by guiding lymphocyte migration both physically, by creating three-dimensional (3D) cell networks, and chemically, by secreting the chemokin ...

American Association of Immunologists ; Oxford University Press2009

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

Materials engineering for immunomodulation

Jeffrey Alan Hubbell, Melody Swartz, Susan Thomas

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intrace ...

2009

An in vitro model of the intestinal lymphatics for transport studies of lipid and drug carriers

Melody Swartz, Sandeep Raghunathan, James Brandon Dixon

2009

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