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Melody Swartz

Cette personne a quitté l’EPFL

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Publications associées (134)

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Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Jeffrey Alan Hubbell, Melody Swartz, Laura Jeanbart, David Scott Wilson, Sachiko Hirosue, Giacomo Olimpio Diaceri

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man-TLR7), which, when conjugated to antige ...

NATURE PUBLISHING GROUP2019

Regulation of lymphatic capillary regeneration by interstitial flow in skin

Melody Swartz

Decreased interstitial flow (IF) in secondary lymphedema is coincident with poor physiological lymphatic regeneration. However, both the existence and direction of causality between IF and lymphangiogenesis remain unclear. This is primarily because the rol ...

2007

seeCell: Visualization and Tracking Dedicated to Cell Analysis

Melody Swartz, Robin Mange

This paper presents a method for the real-time tracking and rendering of dendritic cells in a stream of microscopes images, as implemented in the software seeCell (TM) developed by Visualbiotech (Mange, 2008). The main guideline is how computer graphics te ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2008

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures

Melody Swartz

Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and ...

Springer US2006

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications

Melody Swartz

Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current models that incorporate interstitial flow and that are suitable fo ...

Wiley-Blackwell2010

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Melody Swartz

Disturbances in the microcirculation can lead to secondary lymphedema, a common pathological condition that, despite its frequency, still lacks a cure. Lymphedema is clinically well described, but while the genetic underpinnings that cause lymphatic malfor ...

2006

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

Melody Swartz

Interstitial flow is an important regulator of various cell behaviors both in vitro and in vivo, yet the forces that fluid flow imposes on cells embedded in a 3D extracellular matrix (ECM), and the effects of matrix architecture on those forces, are not we ...

Elsevier2010

Recruitment of CD103(+) dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Lambert Charles François Potin

Although a clinical breakthrough for cancer treatment, it remains that a minority of patients respond to checkpoint inhibitor (CPI) immunotherapy. The composition of tumor-infiltrating immune cells has been identified as a key factor influencing CPI therap ...

2019

Block copolymers and uses thereof

Jeffrey Alan Hubbell, Melody Swartz

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in eac ...

2010

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Melody Swartz, Marco Pisano

Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...

Springer2019

In Vitro Models of Inhalation Toxicity and Disease The Report of a FRAME Workshop

Melody Swartz

2009

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

Melody Swartz, Boris Hinz

The differentiation of fibroblasts to contractile myofibroblasts, which is characterized by de novo expression of alpha-smooth muscle actin (alpha-SMA), is crucial for wound healing and a hallmark of tissue scarring and fibrosis. These processes often foll ...

Company of Biologists2005

Characterization of lymphangiogenesis in a model of adult skin regeneration

Melody Swartz

To date, adult lymphangiogenesis is not well understood. In this study we describe the evolution of lymphatic capillaries in regenerating skin and correlate lymphatic migration and organization with the expression of matrix metalloproteinases (MMPs), immun ...

2006

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Melody Swartz, Douglas Hanahan, Krisztian Homicsko, Laura Jeanbart, Lambert Charles François Potin, Marcela Rincón-Restrepo, Manuel Andreas Fankhauser, Sylvie Hauert, Christopher Claude Giuseppe Tremblay

In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinicall ...

Amer Assoc Advancement Science2017

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

Melody Swartz, Alice Anna Tomei

In the paracortex of the lymph node (LN), T zone fibroblastic reticular cells (TRCs) orchestrate an immune response by guiding lymphocyte migration both physically, by creating three-dimensional (3D) cell networks, and chemically, by secreting the chemokin ...

American Association of Immunologists ; Oxford University Press2009

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

Nature Publishing Group2007

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

Philippe Renaud, Melody Swartz

The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increa ...

2012

Engineered fibrin-binding VEGF-C variant promotes lymphangiogenesis in vitro and in vivo in a dermal wound healing model

Jeffrey Alan Hubbell, Melody Swartz, Esra Güç

2009

Measurement of the inclusive and differential t(t)over-bar gamma cross sections in the dilepton channel and effective field theory interpretation in proton-proton collisions at root s=13 TeV

Olivier Martin, Ian Smith, Matthias Finger, Richard Pitts, Miguel Fernández Ruiz, Sun Hee Kim, Jean-François Carlin, Jian Zhao, Arvind Shah, Chao Wang, Melody Swartz, Yi Zhang, Dalziel Joseph Wilson, Hoài-Minh Nguyên, Pedro Camilo de Oliveira e Silva, Alberto Hernando de Castro, João Miguel das Neves Duarte, Rakesh Chawla, Myun Sik Kim, Tian Cheng, Thomas Mountford, Yixing Chen, Ananda Sankar Roy, Varun Sharma, Bertrand François, Josef Andreas Schuler, Aravind Kumar Chandiran, Yogesh Singh Chauhan, Jae-Woo Choi, Jin Won Seo, Joo Yeon Kim, Wei Sun, Xiaoqiang Wang, Kyumin Lee, Muhammad Aiman Bin Rahmanudin Hamdan, Chia-Chun Chen, Randoald Müller, Alexis Kalogeropoulos, Jung Eung Park, Ana Margarida Da Costa Ricardo, Sebastian James Davis, Melissa Catherine Olson, Christoph Ernst René Schäfer, Adam Wade Marcus, Johannes Steen, Adrien Alexis Paul Chauvet, Hoang-Trang Lam, Maria Isabel Cordero Campana, Carlos Andres Peña Reyes, Justin Terence Notz Pekkanen, Cristopher Ariel Zeballos Avila

The production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e(+/-)mu(-/+), e(+)e(-), or mu(+)mu(-)). The measurement is performed using 138 ...

Springer Nature2022