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Melody Swartz

Cette personne n’est plus à l’EPFL

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Publications associées (136)

Engineering synthetic vaccines using cues from natural immunity

Melody Swartz

Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attac ...

Nature Publishing Group2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

Melody Swartz

Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...

American Society for Clinical Investigation2013

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Amine Issa, Melody Swartz, Sachiko Hirosue, Susan Thomas, Amanda Waite Lund, Vidya Raghavan

Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...

Elsevier2012

Engineering Approaches to Immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue

As the science of immunology grows increasingly mechanistic, motivation for developing quantitative, design-based engineering approaches has also evolved, both for therapeutic interventions and for elucidating immunological pathways in human disease. This ...

American Association for the Advancement of Science2012

Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia

Melody Swartz, Joseph Rutkowski

Wiley-Blackwell2012

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

Melody Swartz

The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support tumor growth and invasion, protect the tumor from host immunity, foster ...

American Association for Cancer Research2012

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Jackson Eby, Sachiko Hirosue, Karen Dane

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

Philippe Renaud, Melody Swartz, Ulrike Haessler, Jeremy Teo

The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increa ...

2012

ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis

Melody Swartz, Renata Katarzyna Mezyk-Kopec

ADAM17 (a disintegrin and metalloprotease 17) is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells. It is generally accepted that ADAM17 promotes tumor development ...

Public Library of Science2012

Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage

Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier, Susan Thomas

Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...

American Association of Immunologists ; Oxford University Press2012

Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization

Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Armando Stano

Background: The development of nanoparticulate antigen-delivery systems is an important emerging area of vaccinology, being sought to amplify immune responses to recombinant antigens that are poorly immunogenic. Nanoparticle size may play an important role ...

Elsevier2012

Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

Melody Swartz, Amanda Waite Lund

2012

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

Jeffrey Alan Hubbell, Melody Swartz, Armando Stano

While current subunit vaccines successfully induce humoral immune responses, a need exists for vaccine strategies to elicit strong cell-mediated immunity to address diseases such as cancer and chronic viral infection. Polymersomes are stable vesicles compo ...

2012

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2011

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma

Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Susan Thomas

Cationic micelles formed from poly(ethylene glycol)-bl-poly(propylene sulfide)-bl-poly(ethylene imine) (PEG-b-PPS-b-PEI) and from mixtures of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-b-PPS) with PEG-b-PPS-b-PEI were explored as non-viral vecto ...

2011

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

Jeffrey Alan Hubbell, Melody Swartz, Cyntia De Piano, Alexandre de Titta, Marie Ballester, Miriella Carmela Pasquier, Eleonora Simeoni, John McKinney, Neeraj Dhar

Vaccines that drive robust T-cell immunity against Mycobacterium tuberculosis (Mtb) are needed both for prophylactic and therapeutic purposes. We have recently developed a synthetic vaccine delivery platform with Pluronic-stabilized polypropylene sulfide n ...

2011

Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Melody Swartz

Lymphatic capillary drainage of interstitial fluid under both steady-state and inflammatory conditions is important for tissue fluid balance, cancer metastasis, and immunity. Lymphatic drainage function is critically coupled to the fluid mechanical propert ...

Elsevier2011

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Armando Stano

Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...

Elsevier2011

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

Jeffrey Alan Hubbell, Melody Swartz, Marie Ballester, Armando Stano, Karen Dane, Benjamin John Marsland

The ability of vaccines to induce memory cytotoxic T-cell responses in the lung is crucial in stemming and treating pulmonary diseases caused by viruses and bacteria. However, most approaches to subunit vaccines produce primarily humoral and only to a less ...

National Academy of Sciences2011

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