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Maria del Carmen Sandi Perez

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Publications associées (191)

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

Maria del Carmen Sandi Perez

Neuroplastin (Np) is a glycoprotein belonging to the immunoglobulin superfamily of cell adhesion molecules (CAMs) and existing in two isoforms, Np55 and Np65, named according to their molecular weights. The extracellular part of Np65 contains three immunog ...

Federation of American Society of Experimental Biology2010

Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Jorge Eduardo Castro Cifuentes, Cristina Marquez Vega, Guillaume Poirier

The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (B ...

Public Library of Science2010

Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

Maria del Carmen Sandi Perez

Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in th ...

Elsevier2010

Differential impact of polysialyltransferase ST8SiaII and ST8iaIV knockout on social interaction and aggression

Maria del Carmen Sandi Perez, Reto Bisaz, Cristina Marquez Vega, Martina Fantin

Previous studies using neuronal cell adhesion molecule (NCAM) -/- knockout (KO) mice provided evidence for a role of NCAMs in social behaviors. However, polysialic acid (PSA), the most important post-translational modification of NCAM, was also absent in t ...

Wiley-Blackwell2010

Learning under stress: a role for the neural cell adhesion molecule NCAM

Maria del Carmen Sandi Perez, Reto Bisaz, Lisa Conboy

Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...

Elsevier2009

Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men

Maria del Carmen Sandi Perez

Stress is a strong modulator of memory function. However, memory is not a unitary process and stress seems to exert different effects depending on the memory type under study. Here, we explored the impact of social stress on different aspects of human memo ...

Frontiers Research Foundation2009

The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

Maria del Carmen Sandi Perez, Lisa Conboy

Agomelatine, a novel antidepressant with established clinical efficacy, acts as a melatonin receptor agonist and 5-HT(2C) receptor antagonist. As stress is a significant risk factor in the development of depression, we sought to determine if chronic agomel ...

Cambridge University Press2009

Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area

Maria del Carmen Sandi Perez, Lisa Conboy

AMPA receptor-mediated synaptic modifications in the amygdala have been reported to sustain cued fear conditioning. However, the hippocampal formation is also critically involved in fear learning. Therefore, we examined whether fear conditioning is also ac ...

Wiley-Blackwell2009

Stress, noradrenaline, and realistic prediction of mouse behaviour using reinforcement learning

Wulfram Gerstner, Maria del Carmen Sandi Perez, Gediminas Luksys

Suppose we train an animal in a conditioning experiment. Can one predict how a given animal, under given experimental conditions, would perform the task? Since various factors such as stress, motivation, genetic background, and previous errors in task perf ...

Curran Associates, Inc.2009

From high anxiety trait to depression: a neurocognitive hypothesis

Maria del Carmen Sandi Perez

Although exposure to substantial stress has a major impact on the development of depression, there is considerable variability in the susceptibility of individuals to the adverse effects of stress. The personality trait of high anxiety has been identified ...

Elsevier2009

Stress-induced cognitive and psychopathological alterations : functional involvement of the neural cell adhesion molecule (NCAM)

Maria del Carmen Sandi Perez, Reto Bisaz

Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...

EPFL2009

Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning

Wulfram Gerstner, Maria del Carmen Sandi Perez, Gediminas Luksys

Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework i ...

Nature Publishing Group2009

Stress, individual differences, and norepinephrine in reinforcement learning-based prediction of mouse behavior in conditioning and spatial learning

Maria del Carmen Sandi Perez, Gediminas Luksys

Acute stress regulates different aspects of behavioral learning through the action of stress hormones and neuromodulators. Stress effects depend on stressor's type, intensity, timing, and the learning paradigm. In addition, genetic background of animals mi ...

EPFL2009

Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule

Maria del Carmen Sandi Perez, Thomas Brionne, Erika Myrna Borcel Novoa

In this study, we examined whether chronic stress in adulthood can exert long-term effects on spatial-cognitive abilities and on the survival of newborn hippocampal cells in aging animals. Male Wistar rats were subjected to chronic unpredictable stress at ...

Lippincott, Williams & Wilkins2008

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Jean-Charles Bensadoun, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Reto Bisaz, Didier Trono, Johan Jakobsson, Anna Claire Groner

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008

Personality traits moderate the impact of chronic stress on depression-like behaviors and hippocampal neurogenesis

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Jorge Eduardo Castro Cifuentes, Cristina Marquez Vega

2008

Adding complexity to emotion-cognition interactions: the stressed individual

Maria del Carmen Sandi Perez

2008

Chronic stress-induced alterations in amygdala responsiveness and behavior - modulation by trait anxiety and corticotropin-releasing factor systems

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana

The basolateral nucleus of the amygdala (BLA) plays a key role in emotional arousal and anxiety, and expresses high levels of corticotropin-releasing factor receptor (CRFR)1. In rat brain slices, we have recently shown that afferent activation of the BLA i ...

Wiley-Blackwell2008

Understanding the neurobiological basis of behavior: a good way to go

Maria del Carmen Sandi Perez

Frontiers Research Foundation2008

A role for NCAM in depression and antidepressant actions?

Maria del Carmen Sandi Perez

Wiley-Blackwell2008

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