Recherche

Afficher tous les résultats pour

Accueil

Personne

Maria del Carmen Sandi Perez

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (191)

Trait anxiety and post-learning stress do not affect perceptual learning

Maria del Carmen Sandi Perez, Michael Herzog, Carl Kristoffer Aberg, Aaron Michael Clarke

While it is well established that stress can modulate declarative learning, very few studies have investigated the influence of stress on non-declarative learning. Here, we studied the influence of post-learning stress, which effectively modulates declarat ...

2012

Evidence for biological roots in the transgenerational transmission of intimate partner violence

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Xavier Fontana, Basira Salehi, Cristina Marquez Vega, Vandana Veenit, Guillaume Poirier

Intimate partner violence is a ubiquitous and devastating phenomenon for which effective interventions and a clear etiological understanding are still lacking. A major risk factor for violence perpetration is childhood exposure to violence, prompting the p ...

2012

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

Maria del Carmen Sandi Perez

The exact function of the adult brain neurogenesis remains elusive, although it has been suggested to play a role in learning and memory processes. In our studies, we employed cyclin D2 gene knockout (cD2 KO) mice showing impaired neurogenesis as well as d ...

2012

Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats

Maria del Carmen Sandi Perez

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, inc ...

Public Library of Science2012

Vulnerability of conditional NCAM-deficient mice to develop stress-induced behavioral alterations

Maria del Carmen Sandi Perez, Reto Bisaz

Previous studies in rodents showed that chronic stress induces structural and functional alterations in several brain regions, including shrinkage of the hippocampus and the prefrontal cortex, which are accompanied by cognitive and emotional disturbances. ...

2012

Evidence for a role of oxytocin receptors in the long-term establishment of dominance hierarchies

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Marjan Timmer

Exposure to stress can affect the establishment of dominance hierarchies. In our model, a social hierarchy established by two male rats during a first encounter is not maintained 1 week later. If one of the two rats is stressed, the stressed rat becomes su ...

2011

Extending the impact of stress on hippocampal neurogenesis

Maria del Carmen Sandi Perez

2011

Glucocorticoids act on glutamatergic pathways to affect memory processes

Maria del Carmen Sandi Perez

Glucocorticoids can acutely affect memory processes, with both facilitating and impairing effects having been described. Recent work has revealed that glucocorticoids may affect learning and memory processes by interacting with glutamatergic mechanisms. In ...

2011

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors

Maria del Carmen Sandi Perez, Hilal Lashuel, Lisa Conboy, Jorge Eduardo Castro Cifuentes

Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...

Nature Publishing Group2011

Causal evidence for the involvement of the neural cell adhesion molecule, NCAM, in chronic stress-induced cognitive impairments

Maria del Carmen Sandi Perez, Reto Bisaz

In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the ...

Wiley-Blackwell2011

Neurobiological Mechanisms Involved in the Establishment and Maintenance of Dominance Hierarchies and its Modulation by Stress in Rats

Maria del Carmen Sandi Perez, Marjan Timmer

Stress can have a strong and long lasting effect on the establishment and maintenance of dominance hierarchies in rats. When two rats of a pair have not been stressed (non-stressed pair) before a first social encounter, they establish a dominance hierarchy ...

EPFL2011

Healing anxiety disorders with glucocorticoids

Maria del Carmen Sandi Perez

National Academy of Sciences2011

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Patrick Aebischer, Nicolas Bouche, Jean-Charles Bensadoun, Maria del Carmen Sandi Perez, Rolf Gruetter, Maria Isabel Cordero Campana, Osiris Marroquin Belaunzaran, Veronica Setola, Maurizio Molinari

BACKGROUND: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current pri ...

Public Library of Science2011

A role for glucocorticoids in the long-term establishment of a social hierarchy

Maria del Carmen Sandi Perez, Marjan Timmer

Stress can affect the establishment and maintenance of social hierarchies. In the present study, we investigated the role of increasing corticosterone levels before or just after a first social encounter between two rats of a dyad in the establishment and ...

Elsevier2010

Learning, Stress and the Role of Personality Profiles in Rats

Maria del Carmen Sandi Perez, Basira Salehi

Stress has been shown to modulate many aspects of physiology and behavior. In particular, substantial work has confirmed that stress is a strong modulator of learning and memory processes. It is more than a century that Yerkes and Dodson have shown that re ...

EPFL2010

Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

Maria del Carmen Sandi Perez, Martina Fantin

Neural cell adhesion molecule (NCAM)-mediated cell adhesion results in activation of intracellular signaling cascades that lead to cellular responses such as neurite outgrowth, neuronal survival, and modulation of synaptic activity associated with cognitiv ...

2010

Learning under stress: the inverted-U-shape function revisited

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Basira Salehi

Although the relationship between stress intensity and memory function is generally believed to follow an inverted-U-shaped curve, strikingly this phenomenon has not been demonstrated under the same experimental conditions. We investigated this phenomenon ...

Cold Spring Harbor Laboratory Press2010

Role of NCAM in emotion and learning

Maria del Carmen Sandi Perez, Kamila Markram, Reto Bisaz, Lisa Conboy

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regula ...

2010

The role of NCAM in auditory fear conditioning and its modulation by stress: a focus on the amygdala

Maria del Carmen Sandi Perez, Reto Bisaz

Chronic stress in rodents was shown to induce structural shrinkage and functional alterations in the hippocampus that were linked to spatial memory impairments. Effects of chronic stress on the amygdala have been linked to a facilitation of fear conditioni ...

Wiley-Blackwell2010

Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action

Maria del Carmen Sandi Perez, Lisa Conboy

Stress and glucocorticoids (GCs) can facilitate memory formation. However, the molecular mechanisms mediating their effects are largely unknown. alpha-Amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) trafficking has been implicat ...

Nature Publishing Group2010

Page 8 sur 10