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Maria del Carmen Sandi Perez

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Publications associées (191)

Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis

Maria del Carmen Sandi Perez, Mandy Meijer

DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms facilitating the interplay of genomic and environmental factors, which can contribute to externalizing behaviours and related psychiatric disorders. Previous epigenome-wide ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Maria del Carmen Sandi Perez

The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the association bet ...

Nature Research2023

Glucocorticoid-based pharmacotherapies preventing PTSD

Maria del Carmen Sandi Perez, Silvia Monari

Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...

2023

Transcriptomic analysis reveals mitochondrial pathways associated with distinct behavioral phenotypes and adolescent stress

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Wiley2023

Powering the social brain: Mitochondria in social behaviour

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Silvie Rosalie Ruigrok

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

2023

A response to claims of emergent intelligence and sentience in a dish

Maria del Carmen Sandi Perez, Mackenzie Mathis

CELL PRESS2023

Commentary: Alpha(1)-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

Maria del Carmen Sandi Perez, Loris Constantin, Anna Lasne, Merkourios Simos

FRONTIERS MEDIA SA2023

PSYCHOSOCIAL EXPERIENCES AND THE MITOCHONDRIAL BRAIN PROTEOME IN OLDER ADULTS

Maria del Carmen Sandi Perez

Lippincott Williams & Wilkins2023

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Sophie Elizabeth Walker, Marie-Isabelle Guillot de Suduiraut, Simone Astori, Silvia Monari

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

2023

Pre-pandemic Psychobiological Features Predict Impact of COVID-19 Confinement on Loneliness

Maria del Carmen Sandi Perez

The coronavirus disease 2019 (COVID-19) pandemic led to various government-imposed limitations on social interaction and strict home confinement. Such involuntary social-distancing policies can exacerbate feelings of loneliness and alter emotional well-bei ...

Frontiers Media2022

CAFS: Cost-Aware Features Selection Method for Multimodal Stress Monitoring on Wearable Devices

Maria del Carmen Sandi Perez, David Atienza Alonso, Adriana Arza Valdes, João Pedro de Matos Rodrigues, Niloofar Momeni

Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multim ...

2022

Signatures of life course socioeconomic conditions in brain anatomy

Maria del Carmen Sandi Perez, Bogdan Draganski

Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the bra ...

Wiley2022

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Bernard Lanz, Maria del Carmen Sandi Perez, Rolf Gruetter, Carole Poitry-Yamate, Antoine Timothée Cherix, Olivia Zanoletti, Jocelin Grosse

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

SPRINGERNATURE2022

Acute stress affects peripersonal space representation in cortisol stress responders

Maria del Carmen Sandi Perez, John Christian Thoresen, Andrea Serino, Manon Chloé Durand-Ruel

Peripersonal space is the representation of the space near the body. It is implemented by a dedicated multisensory-motor network, whose purpose is to predict and plan interactions with the environment, and which can vary depending on environmental circumst ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...

Cell Press2022

Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

Maria del Carmen Sandi Perez, Jocelin Grosse

Creatine (Cr) is a nitrogenous organic acid and plays roles such as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, and as a compound with anabolic and ergogenic properties in muscle. Cr is taken from the diet or endog ...

WILEY2022

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Maria del Carmen Sandi Perez, Simone Astori, Eva Ramos Fernandez

Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import of pyruvate into mitochondria occuring exclusively via the mitochondrial pyruva ...

eLIFE SCIENCES PUBL LTD2022

Addressing the opportunity gap in the Latin American neuroscience community

Maria del Carmen Sandi Perez

Although issues surrounding diversity and inclusion in science are global, distinctive region-specific socioeconomic factors and operational biases interact to widen the opportunity gap and exacerbate the isolation of specific groups of disadvantaged scien ...

NATURE PORTFOLIO2022

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Maria del Carmen Sandi Perez, Olivia Zanoletti, Maude Schneider, Farnaz Delavari

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...

2022

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Pascal Steiner, Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, Fiona Hollis, Alina Veronika Irene Strasser, Ioannis Zalachoras, Simone Astori, João Pedro de Matos Rodrigues, Eva Ramos Fernandez

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...

2022

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