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Maria del Carmen Sandi Perez

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Related publications (188)

Page 2 of 10

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq

The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...

2020

Learning under stress: a role for the neural cell adhesion molecule NCAM

Maria del Carmen Sandi Perez

Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...

Elsevier2009

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Aurélie Lattion

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence enhances the risk of psychopathology later in life. We have previously shown that subjecting male rats to stress during the peripubertal period induces long-lasting effects on emotion and social behaviors. As cortico ...

Frontiers Research Foundation2013

Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala

Jean-Christophe Copin, Maria del Carmen Sandi Perez, Hilal Lashuel, Johannes Burtscher

Increasing evidence suggests that crosstalk between α-synuclein pathology formation and mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson’s disease and related synucleinopathies. While mitochondrial dysfunction is a well-studi ...

2020

Cultural Adaptation, Validation, and Psychometric Description of the Pictorial Empathy Test (PET) in the Spanish Population

Maria del Carmen Sandi Perez

Research in psychology and social neuroscience distinguishes between dispositional and situational empathy for the cognitive and affective aspects of empathy. Yet, the Pictorial Empathy Test (PET) is one of the few brief tests focusing on situational affec ...

HOGREFE PUBLISHING CORP2022

Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht

Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as potential factors underlying disorders like autism and schizophrenia resulting in associated behavioral alterations including changes in social and emotional be ...

Public Library of Science2013

Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

Maria del Carmen Sandi Perez, Jocelin Grosse

Creatine (Cr) is a nitrogenous organic acid and plays roles such as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, and as a compound with anabolic and ergogenic properties in muscle. Cr is taken from the diet or endog ...

WILEY2022

Neurobiological links between stress and anxiety

Maria del Carmen Sandi Perez

Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major ...

2019

Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis

Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...

2018

Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress

Rolf Gruetter, Maria del Carmen Sandi Perez, Hongxia Lei, João Pedro de Matos Rodrigues, Antoine Timothée Cherix, Thomas Didier Larrieu

Extensive data highlight the existence of major differences in individuals’ susceptibility to stress [1; 2; 3 ; 4]. While genetic factors [5 ; 6] and exposure to early life stress [7 ; 8] are key components for such neurobehavioral diversity, intriguing ob ...

2017

From high anxiety trait to depression: a neurocognitive hypothesis

Maria del Carmen Sandi Perez

Although exposure to substantial stress has a major impact on the development of depression, there is considerable variability in the susceptibility of individuals to the adverse effects of stress. The personality trait of high anxiety has been identified ...

Elsevier2009

Evidence for biological roots in the transgenerational transmission of intimate partner violence

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier, Vandana Veenit, Basira Salehi

Intimate partner violence is a ubiquitous and devastating phenomenon for which effective interventions and a clear etiological understanding are still lacking. A major risk factor for violence perpetration is childhood exposure to violence, prompting the p ...

2012

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

Maria del Carmen Sandi Perez, Olivia Zanoletti, Guillaume Poirier

Adolescence is increasingly recognized as a critical period for the development of the social system, through the maturation of social competences and of their underlying neural circuitries. The present study sought to test the utility of resveratrol, a di ...

2014

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Maria del Carmen Sandi Perez, Simone Astori, Damien Sébastien Huzard

The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...

2020

Learning improvement after PI3K activation correlates with de novo formation of functional small spines

Maria del Carmen Sandi Perez

PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide ...

2014

Stress and cognition

Maria del Carmen Sandi Perez

Stress can affect cognition in many ways, with the outcome (i.e., facilitating or impairing) depending on a combination of factors related to both stress and the cognitive function under study. Among the factors identified as particularly relevant to defin ...

Wiley-Blackwell2013

Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats

Maria del Carmen Sandi Perez

Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, inc ...

Public Library of Science2012

Trait anxiety on effort allocation to monetary incentives: a behavioral and high-density EEG study

Maria del Carmen Sandi Perez, João Pedro de Matos Rodrigues, Alina Veronika Irene Strasser

Trait anxiety is an important phenotype in the prediction of stress-induced neuropsychiatric disorders. While the role of trait anxiety in mental effort and cognitive impairment is well documented, much less is known about its influence on motivated behavi ...

2019

Powering the social brain: Mitochondria in social behaviour

Silvie Rosalie Ruigrok, Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

2023