Maria del Carmen Sandi Perez

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Publications associées (191)

Abnormal fear conditioning and amygdala processing in an animal model of autism

Tania Rinaldi, Deborah La Mendola, Henry Markram, Maria del Carmen Sandi Perez, Kamila Markram

A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...

Nature Publishing Group2008

A model for the involvement of neural cell adhesion molecules in stress-related mood disorders

Maria del Carmen Sandi Perez, Reto Bisaz

Critical interactions between genetic and environmental factors -- among which stress is one of the most potent non-genomic factors -- are involved in the development of mood disorders. Intensive work during the past decade has led to the proposal of the n ...

Karger2007

Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation

Maria del Carmen Sandi Perez

The role of the hippocampus in pavlovian fear conditioning is controversial. Although lesion and pharmacological inactivation studies have suggested a key role for the dorsal hippocampus in contextual fear conditioning, the involvement of the ventral part ...

2007

Effects of P2, a peptide derived from a homophilic binding site in the neural cell adhesion molecule on learning and memory in rats

Maria del Carmen Sandi Perez

The neural cell adhesion molecule (NCAM) plays a pivotal role in neural development, regeneration, synaptic plasticity, and memory processes. P2 is a 12-amino-acid peptide derived from the second immunoglobulin-like (Ig) module of NCAM mediating cis-homoph ...

2007

The role of the amygdala in emotional memories : a multidisciplinary approach

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007

Stress before puberty exerts a sex- and age-related impact on auditory and contextual fear conditioning in the rat

Maria del Carmen Sandi Perez

Adolescence is a period of major physical, hormonal, and psychological changes. It is also characterized by a significant increase in the incidence of psychopathologies and this increase is gender-specific. Stress during adolescence is associated with the ...

2007

Stress and memory: behavioral effects and neurobiological mechanisms

Maria del Carmen Sandi Perez

Stress is a potent modulator of learning and memory processes. Although there have been a few attempts in the literature to explain the diversity of effects (including facilitating, impairing, and lack of effects) described for the impact of stress on memo ...

2007

Effects of stress and genotype on meta-parameter dynamics in reinforcement learning

Wulfram Gerstner, Jérémie Knüsel, Maria del Carmen Sandi Perez, Gediminas Luksys

Stress and genetic background regulate different aspects of behavioral learning through the action of stress hormones and neuromodulators. In reinforcement learning (RL) models, meta-parameters such as learning rate, future reward discount factor, and expl ...

2007

Cellular mechanisms regulating adult neurogenesis and olfactory perception in mice

Maria del Carmen Sandi Perez, Thomas Brionne

In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...

EPFL2007

Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction

Maria del Carmen Sandi Perez, Kamila Markram

There is much interest to understand the mechanisms leading to the establishment, maintenance, and extinction of fear memories. The amygdala has been critically involved in the processing of fear memories and a number of molecular changes have been implica ...

2007

Stress amplifies memory for social hierarchy

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana

Individuals differ in their social status and societies in the extent of social status differences among their members. There is great interest in understanding the key factors that contribute to the establishment of social dominance structures. Given that ...

Frontiers Research Foundation2007

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