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Luca Dede'

Cette personne a quitté l’EPFL

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Publications associées (37)

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The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Alfio Quarteroni, Luca Dede', Stefano Pagani

Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are transduced into electrical signals, have received sparse investigation by considering electromechanical simulations in simplified scenarios. In this paper, we study the effects of di ...

2022

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Alfio Quarteroni, Luca Dede'

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Alfio Quarteroni, Francesco Regazzoni, Luca Dede'

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

SPRINGER SINGAPORE PTE LTD2021

Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws

Alfio Quarteroni, Simone Deparis, Luca Dede', Paolo Tricerri

This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...

Springer Verlag2015

Active contraction of cardiac cells: a reduced model for sarcomere dynamics with cooperative interactions

Alfio Quarteroni, Francesco Regazzoni, Luca Dede'

We propose a reduced ODE model for the mechanical activation of cardiac myofilaments, which is based on explicit spatial representation of nearest-neighbour interactions. Our model is derived from the cooperative Markov Chain model of Washio et al. (Cell M ...

SPRINGER HEIDELBERG2018

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

Alfio Quarteroni, Luca Dede'

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...

Wiley2023

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Alfio Quarteroni, Luca Dede', Luca Pegolotti

We consider Isogeometric Analysis (IGA) for the numerical solution of the electrophysiology of the atria, which in this work is modeled by means of the bidomain equations on thin surfaces. First, we consider the bidomain equations coupled with the Roger-Mc ...

ELSEVIER SCIENCE SA2019

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Luca Barbarotta, Alfio Quarteroni, Luca Dede', Simone Rossi

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

Alfio Quarteroni, Luca Dede'

Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the ...

Elsevier2023

Coupled models for integrated heart simulations: a numerical study of the fluid dynamics in the left ventricle

Alfio Quarteroni, Simone Deparis, Luca Dede', Davide Forti, Antonello Gerbi

We consider the numerical simulation of integrated heart models for the study of the cardiac functioning with particular emphasis on the coupling of the muscle contraction, the fluid dynamics of the left ventricle, and the interaction with the valves. We a ...

CMBE, Zeta Computational Resources Ltd.2015

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

Alfio Quarteroni, Luca Dede', Toni Mikael Lassila, Alessandro Samuele Patelli, Andrea Bartezzaghi

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p >= 1 ...

Elsevier2017

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Alfio Quarteroni, Luca Dede', Antonello Gerbi

In this paper, we propose a monolithic algorithm for the numerical solution of the electromechanics model of the left ventricle in the human heart. Our coupled model integrates the monodomain equation with the Bueno-Orovio minimal model for electrophysiolo ...

2018

Isogeometric Analysis of high order Partial Differential Equations on surfaces

Alfio Quarteroni, Luca Dede', Andrea Bartezzaghi

We consider the numerical approximation of high order Partial Differential Equations (PDEs) defined on surfaces in the three dimensional space, with particular emphasis on closed surfaces. We consider computational domains that can be represented by B-spli ...

Elsevier2015

Biomembrane modeling with isogeometric analysis

Alfio Quarteroni, Luca Dede', Andrea Bartezzaghi

We consider the numerical approximation of lipid biomembranes at equilibrium described by the Canham-Helfrich model, according to which the bending energy is minimized under area and volume constraints. Energy minimization is performed via L-2-gradient flo ...

ELSEVIER SCIENCE SA2019

A numerical study of isotropic and anisotropic constitutive models with relevance to healthy and unhealthy cerebral arterial tissues

Alfio Quarteroni, Luca Dede', Paolo Tricerri

This paper presents an analysis of hyperelastic constitutive models for continuous bodies both from a modeling and numerical point of view. Contributions are made within the context of finite element numerical simulations. Numerical results with relevance ...

Elsevier2016

Reduced Basis Method for Parametrized Differential Algebraic Equations

Alfio Quarteroni, Luca Dede'

Parametrized systems of Differential Algebraic Equations (DAEs) stand at the base of several mathematical models in Microelectronics, Computational Fluid Dynamics and other Engineering fields. Since the dimension of these systems can be huge, high computat ...

2009

Data integration for the numerical simulation of cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani

The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...

WILEY2021

Isogeometric Analysis of geometric partial differential equations

Alfio Quarteroni, Luca Dede', Andrea Bartezzaghi

We consider the numerical approximation of geometric Partial Differential Equations (PDEs) defined on surfaces in the 3D space. In particular, we focus on the geometric PDEs deriving from the minimization of an energy functional by L2L2-gradient flow. We a ...

Elsevier2016

Well-Posedness, Regularity, and Convergence Analysis of the Finite Element Approximation of a Generalized Robin Boundary Value Problem

Alfio Quarteroni, Luca Dede', Claudia Maria Colciago

In this paper, we propose the mathematical and finite element analysis of a second-order partial differential equation endowed with a generalized Robin boundary condition which involves the Laplace--Beltrami operator by introducing a function space $H^1(\O ...

Society for Industrial and Applied Mathematics2015