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Harm-Anton Klok

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Publications associées (195)

Selective Peptide-Mediated Enhanced Deposition of Polymer Fragrance Delivery Systems on Human Hair

Harm-Anton Klok, Kemal Arda Günay

The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, pha ...

2017

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

Harm-Anton Klok, Claudia Battistella

Inhibition of P-glycoprotein (P-gp) transporter is an attractive approach for the reversion of cancer-associated multidrug resistance (MDR). Poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA)-based carriers that are able to release the anticancer drug doxoru ...

American Chemical Society2017

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

Harm-Anton Klok, Maarten Danial, Frederik Roman Wurm

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...

2017

Surface-Initiated Controlled Radical Polymerization: State-of-the-Art, Opportunities, and Challenges in Surface and Interface Engineering with Polymer Brushes

Harm-Anton Klok, Nariye Cavusoglu Ataman, John Moraes, Justin Orazio Zoppe, Piotr Mocny, Jian Wang

The generation of polymer brushes by surface-initiated controlled radical polymerization (SI-CRP) techniques has become a powerful approach to tailor the chemical and physical properties of interfaces and has given rise to great advances in surface and int ...

2017

Microcomputed Tomography Technique for In Vivo Three-Dimensional Fat Tissue Volume Evaluation After Polymer Injection

Harm-Anton Klok, Ioana Konz

Tissue engineering technologies are new and promising techniques in fat tissue reconstruction. However, to assess their efficacy before any clinical application, in vivo experiments are mandatory. This study assesses whether microcomputed tomography (CT) s ...

2017

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Harm-Anton Klok, Claudia Battistella

Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive a ...

2017

The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

Harm-Anton Klok, Michele Graciotti, Cristiana Berti

Background: Immunotherapy consists of activating the patient's immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system a ...

2017

Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans

Harm-Anton Klok, Piotr Mocny

There is a need for coatings for biomedical devices and implants that can prevent the attachment of fungal pathogens while allowing human cells and tissue to appose without cytotoxicity. Here, the authors study whether a poly(2-hydroxyethylmethacrylate) (P ...

2017

Cell-mediated delivery of synthetic nano- and microparticles funding

Harm-Anton Klok, Maxime Ayer

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to expl ...

2017

Peptide-Enhanced Selective Surface Deposition of Polymer-Based Fragrance Delivery Systems

Harm-Anton Klok

Surface deposition is a critical step in the application of fragrance-containing products. This contribution presents a novel strategy to enhance the deposition of polymer-based fragrance delivery systems onto cotton substrates from the application medium ...

2017

Cellulose Nanocrystals with Tethered Polymer Chains: Chemically Patchy versus Uniform Decoration

Alke Fink, Harm-Anton Klok, Théo Gaston Gérard Lachat, Justin Orazio Zoppe, Alix Vaimiti Marie Dupire

The site-specific surface modification of colloidal substrates, yielding "patchy" nanoparticles, is a rapidly expanding area of research as a result of the new complex structural hierarchies that are becoming accessible to chemists and materials scientists ...

2017

Click Chemistry in Biomaterials, Nanomedicine, and Drug Delivery

Harm-Anton Klok

American Chemical Society2016

Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

Harm-Anton Klok, Matthew Gibson

A library of polymer-coated gold nanoparticles (AuNPs) differing in size and surface modifications was examined for uptake and induction of cellular stress responses in the endoplasmic reticulum (ER stress) in human brain endothelial cells (hCMEC/D3). ER s ...

Informa Healthcare2016

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

Harm-Anton Klok

Cyclic peptide disulfides (CXC) are an important class of biomolecules. The conjugation of cyclic peptide disulfides to synthetic polymers, however, is often difficult due to the presence of the disulfide bond combined with other potentially reactive side ...

Royal Society of Chemistry2016

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

Harm-Anton Klok, Muriel Blum, Raoul Peltier, John Moraes

The use of polymers has revolutionized the field of drug delivery in the past two decades. Properties such as polymer size, charge, hydrophilicity, or branching have all been shown to play an important role in the cellular internalization of polymeric syst ...

2016

Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Sorin Alexandru Ibanescu

Thin polymer films that prevent the adhesion of bacteria are of interest as coatings for the development of infection-resistant biomaterials. This study investigates the influence of grafting density and film thickness on the adhesion of Staphylococcus epi ...

Wiley-Blackwell2016

Effect of Surface Charge on Surface-Initiated Atom Transfer Radical Polymerization from Cellulose Nanocrystals in Aqueous Media

Harm-Anton Klok, Justin Orazio Zoppe, Xingyu Xu

Cellulose nanocrystals (CNCs) with different charge densities were utilized to examine the role of electrostatic interactions on surface-initiated atom transfer radical polymerization (SI-ATRP) in aqueous media. To this end, growth of hydrophilic uncharged ...

American Chemical Society2016

Swelling Behavior and Nanomechanical Properties of (Peptide-Modified) Poly(2-hydroxyethyl methacrylate) and Poly(poly(ethylene glycol) methacrylate) Brushes

Harm-Anton Klok, Nicolas Bertrand Schüwer, Solenne Desseaux, Juan Pablo Hinestrosa Salazar, Kislon Voitchovsky

Poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(poly(ethylene glycol) methacrylate) (PPEGMA) brushes represent a class of thin, surface-tethered polymer films that have been extensively used e.g. to generate non-biofouling surfaces or as model systems t ...

American Chemical Society2016

Tribology of surface-grafted polymer brushes

Harm-Anton Klok, Piotr Mocny

Surface-grafted polymer brushes are a very attractive class of boundary lubricants. This article presents an overview of the tribological properties of surface-attached synthetic polymers. After a brief review of some mechanistic considerations and a discu ...

Royal Soc Chemistry2016

Degrafting of Poly(poly(ethylene glycol) methacrylate) Brushes from Planar and Spherical Silicon Substrates

Harm-Anton Klok, Nariye Cavusoglu Ataman

Densely grafted, hydrophilic polymer brushes produced via surface-initiated controlled radical polymerization have been shown to undergo degrafting upon exposure to aqueous media. This degrafting process has been proposed to involve swelling-induced, mecha ...

American Chemical Society2016

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