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Harm-Anton Klok

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Publications associées (195)

Macromolecular engineering via polyhomologation

Harm-Anton Klok

Polyhomologation of ylide monomers by organoboron initiators is a powerful and versatile C1 polymerization method that provides access to linear polyolefins (polymethylenes) that share structural and compositional similarity with polyethylene. Oxidative hy ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Lignin: A Sustainable Antiviral Coating Material

Jeremy Luterbacher, Harm-Anton Klok, Francesco Stellacci, Stefania Bertella, Alice Boarino, Francesca Olgiati, Heyun Wang

Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. Antiviral surface coatings are useful to minimize such risks. Current state-of-the-art approaches toward antiviral surface coatings eit ...

AMER CHEMICAL SOC2022

Specific Counterion Effects on the Swelling Behavior of Strong Polyelectrolyte Brushes

Harm-Anton Klok

It is well known that specific types of counterions affect the hydration of polyelectrolytes both in the bulk and at interfaces, but the mechanisms of this effect have not yet been fully understood. In this work, we have designed a model system, consisting ...

American Chemical Society2022

Uniformly Dispersed Poly(lactic acid)-Grafted Lignin Nanoparticles Enhance Antioxidant Activity and UV-Barrier Properties of Poly(lactic acid) Packaging Films

Yves Leterrier, Harm-Anton Klok, Aigoul Schreier, Alice Boarino

Poly(lactic acid) (PLA) represents one of the most widely used biodegradable polymers for food packaging applications. While this material provides many advantages, it is characterized by limited antioxidant and UV-barrier properties. Blending PLA with lig ...

AMER CHEMICAL SOC2022

Sustainable polyesters via direct functionalization of lignocellulosic sugars

Yves Leterrier, Véronique Michaud, François Maréchal, Jeremy Luterbacher, Harm-Anton Klok, Graham Reid Dick, Adrien Julien Demongeot, Christèle Rayroud, Maxime Alexandre Clément Hedou, Thibault Rambert

The development of sustainable plastics from abundant renewable feedstocks has been limited by the complexity and efficiency of their production, as well as their lack of competitive material properties. Here we demonstrate the direct transformation of the ...

2022

Mechanical Acceleration of Ester Bond Hydrolysis in Polymers

Harm-Anton Klok, Anne-Clémence Corminboeuf, Jian Wang, Alice Boarino, Frédéric Célerse

Polymers containing ester bonds are ubiquitous. Often, these materials are mechanically challenged, which impacts their stability and degradation. While the accelerative effect of force on the degradation of polyester polymers is well recognized, little is ...

American Chemical Society2022

Polymethylene Brushes via Surface-Initiated C1 Polyhomologation

Harm-Anton Klok

Surface-initiated polymerization reactions are a powerful tool to generate chain-end-tethered polymer brushes. This report presents a synthetic strategy that gives access to structurally well-defined hydrocarbon polymer brushes of controlled molecular weig ...

AMER CHEMICAL SOC2021

A minimalistic cyclic ice-binding peptide from phage display

Harm-Anton Klok, Matthew Gibson, Luciano Andres Abriata, Xudong Kong, Corey Alfred Stevens

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

Nature Research2021

Reduction-Sensitive Protein Nanogels Enhance Uptake of Model and Tumor Lysate Antigens In Vitro by Mouse- and Human-Derived Dendritic Cells

Harm-Anton Klok, Lisa Patricia Elisabeth Bader, Cristiana Berti, Alice Boarino

Peptides and proteins represent an emerging class of powerful therapeutics. Peptide and protein nanogels are attractive carriers for the transport and delivery of biologically active peptides and proteins because they allow essentially quantitative encapsu ...

AMER CHEMICAL SOC2021

Succinimidyl Carbonate-Based Amine-Reactive Polymer Brushes: Facile Fabrication of Functional Interfaces

Harm-Anton Klok

Polymeric coatings that can undergo effective functionalization with ligands and (bio)molecules necessary for intended applications are widely employed to engineer functional interfaces. Herein, amine-reactive polymer brushes are fabricated using a succini ...

2021

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Harm-Anton Klok, Olivier Burri, Maxime Ayer, Arne Seitz, Romain Guiet

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

2021

Polymer Nanoparticle-Mediated Delivery of Oxidized Tumor Lysate-Based Cancer Vaccines

Harm-Anton Klok, Cristiana Berti, Alice Boarino

Cancer vaccination is a powerful strategy to combat cancer. A very attractive approach to prime the immune system against cancer cells involves the use of tumor lysate as antigen source. The immunogenicity of tumor lysate can be further enhanced by treatme ...

2021

Branched Poly(Aryl Piperidinium) Membranes for Anion-Exchange Membrane Fuel Cells

Harm-Anton Klok, Xile Hu, Xingyu Wu

Anion-exchange membrane fuel cells (AEMFCs) are a promising, next-generation fuel cell technology. AEMFCs require highly conductive and robust anion-exchange membranes (AEMs), which are challenging to develop due to the tradeoff between conductivity and wa ...

Wiley-VCH Verlag GmbH2021

Chemical Cell Surface Modification and Analysis of Nanoparticle-Modified Living Cells

Harm-Anton Klok, Tanja Thomsen

Cells are promising as carriers that can enhance the delivery of nanomedicines. Cells that carry nanomedicinal cargo, either immobilized on the cell surface or internalized, can allow for highly specific delivery and can enable the transport of nanomedicin ...

AMER CHEMICAL SOC2021

Self-assembly of protein-polymer conjugates for drug delivery

Harm-Anton Klok, Corey Alfred Stevens, Kuljeet Kaur

Protein-polymer conjugates are a class of molecules that combine the stability of polymers with the diversity, specificity, and functionality of biomolecules. These bioconjugates can result in hybrid materials that display properties not found in their ind ...

2021

Fluorescence-Based and Fluorescent Label-Free Characterization of Polymer Nanoparticle Decorated T Cells

Harm-Anton Klok, Demetri Psaltis, Tanja Thomsen, Ahmed Bassam Sayed Ayoub Mohamed Emam

Cells are attractive carriers for the transport and delivery of nanoparticulate cargo. The use of cell-based carriers allows one to enhance control over the biodistribution of drug-loaded polymers and polymer nanoparticles. One key element in the developme ...

American Chemical Society2021

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes

Harm-Anton Klok, Tanja Thomsen

Cells are attractive as carriers that can help to enhance control over the biodistribution of polymer nanomedicines. One strategy to use cells as carriers is based on the cell surface immobilization of the nanoparticle cargo. While a range of strategies ca ...

American Chemical Society2021

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

Harm-Anton Klok, Olivier Burri, Maxime Ayer, Arne Seitz, Romain Guiet, Markus Schuster

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intr ...

WILEY2020

Complex polymer topologies and polymer-nanoparticle hybrid films prepared via surface-initiated controlled radical polymerization

Harm-Anton Klok, Piotr Mocny

Advances in controlled radical polymerization over the past two decades have transformed the ability to produce molecularly well-defined, chain-end tethered polymer brush films. The assets of controlled radical polymerization reactions have impacted the sy ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Reversibly Cross-Linking Polymer Brushes Using Interchain Disulfide Bonds

Harm-Anton Klok, Piotr Mocny

The introduction of interchain cross-links in surface-grafted polymer brushes increases the robustness and mechanical properties of these thin polymer films. In most cases, cross-linked polymer brushes contain permanent interchain cross-links. The use of r ...

American Chemical Society2020

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