Recherche

Afficher tous les résultats pour

Accueil

Personne

Henry Markram

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (169)

A history of spike-timing-dependent plasticity

Wulfram Gerstner, Henry Markram

How learning and memory is achieved in the brain is a central question in neuroscience. Key to today’s research into information storage in the brain is the concept of synaptic plasticity, a notion that has been heavily influenced by Hebb’s (1949) postulat ...

2011

Organizing neural networks

Henry Markram, Rodrigo de Campos Perin, Thomas Berger

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by betwe ...

2011

Encoding and decoding of information

Henry Markram

Method and system for weighting the amplitude of an event in a time -based code. The time-based code is divided into time intervals. Each of the time intervals of the time-based code corresponds to a digit in the received signal. Each digit of a first stat ...

2011

Ephaptic coupling of cortical neurons

Henry Markram, Rodrigo de Campos Perin, Constantinos Anastassiou

The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potential across the neuronal membrane via ephaptic coupling, independ ...

2011

Innate neural assemblies for lego memory

Henry Markram, Rodrigo de Campos Perin

2011

Effective Stimuli for Constructing Reliable Neuron Models

Henry Markram, Thomas Berger, Felix Schürmann, Sean Lewis Hill, Idan Segev

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

2011

Newsmaker interview: Heny Markram Blue Brain founder responds to critics, clarifies his goals

Henry Markram

Editorial Material ...

American Association for the Advancement of Science2011

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

Luca Gambazzi, Henry Markram, Heike Runne, Ozgün Gökce, Michele Giugliano, Elena Katsyuba

Although previous studies of Huntington's disease (HD) have addressed many potential mechanisms of striatal neuron dysfunction and death, it is also known, based on clinical findings, that cortical function is dramatically disrupted in HD. With respect to ...

American Society for Pharmacology and Experimental Therapeutics2010

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

Henry Markram, Gilad Silberberg, Rodrigo de Campos Perin, Thomas Berger

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the ...

Public Library of Science2010

The intense world theory - a unifying theory of the neurobiology of autism

Henry Markram, Kamila Markram

Autism covers a wide spectrum of disorders for which there are many views, hypotheses and theories. Here we propose a unifying theory of autism, the Intense World Theory. The proposed neuropathology is hyper-functioning of local neural microcircuits, best ...

2010

Substrate arrays of iridium oxide microelectrodes for in-vitro neuronal interfacing

Marc Olivier Heuschkel, Shady Didier Gawad, Philippe Renaud, Henry Markram, Michele Giugliano

The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...

2009

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Tania Rinaldi, Jean-Vincent Le Bé, Henry Markram, Kamila Markram, Imad Riachi, Guilherme Silva

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...

2009

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Henry Markram, Gilad Silberberg, Daniela Helbig

Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range. In ...

2009

A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON

Henry Markram, Felix Schürmann, Michael Lee Hines, Sean Lewis Hill

As neuronal simulations approach larger scales with increasing levels of detail, the neurosimulator software represents only a part of a chain of tools ranging from setup, simulation, interaction with virtual environments to analysis and visualizations. Pr ...

2009

Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex

Henry Markram, Gilad Silberberg, Rodrigo de Campos Perin, Thomas Berger

The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...

2009

Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts

Luca Gambazzi, Henry Markram, Michele Giugliano

Carbon nanotubes have been applied in several areas of nerve tissue engineering to probe and augment cell behaviour, to label and track subcellular components, and to study the growth and organization of neural networks. Recent reports show that nanotubes ...

Nature Publishing Group2009

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

Tania Rinaldi, Henry Markram, Catherine Perrodin

The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are ho ...

2008

Fully implicit parallel simulation of single neurons

Henry Markram, Felix Schürmann

When a multi-compartment neuron is divided into subtrees such that no subtree has more than two connection points to other subtrees, the subtrees can be on different processors and the entire system remains amenable to direct Gaussian elimination with only ...

2008

Fixing the location and dimensions of functional neocortical columns

Henry Markram

The quest to understand the way in which neurons interconnect to form circuits that function as a unit began when Ramon y Cajal concluded that axo-dendritic apposition were too conspicuous to be incidental and proposed that two neurons must be communicatin ...

2008

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

Henry Markram, Thomas Berger, Felix Schürmann, Sean Lewis Hill, Idan Segev

Neuron models, in particular conductance-based compartmental models, often have numerous parameters that cannot be directly determined experimentally and must be constrained by an optimization procedure. A common practice in evaluating the utility of such ...

2008

Page 7 sur 9