Recherche

Afficher tous les résultats pour

Accueil

Personne

Bernard Schneider

Cette personne a quitté l’EPFL

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (107)

Page 5 sur 6

Liver SMN restoration rescues the Smn2B/- mouse model of spinal muscular atrophy

Bernard Schneider

Background: The liver is a key metabolic organ, acting as a hub to metabolically connect various tissues. Spinal muscular atrophy (SMA) is a neuromuscular disorder whereby patients have an increased susceptibility to developing dyslipidaemia and liver stea ...

2024

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

Bernard Schneider, Nicholas David James

Chondroitin sulphate proteoglycans (CSPGs) are known to be important contributors to the intensely inhibitory environment that prevents tissue repair and regeneration following spinal cord injury. The bacterial enzyme chondroitinase ABC (ChABC) degrades th ...

Elsevier2015

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

Patrick Aebischer, Bernard Schneider, Nicole Déglon

We developed an ex vivo gene therapy approach for the regulated delivery of therapeutic proteins based on the implantation of encapsulated, genetically engineered C(2)C(12) myoblasts. We investigated doxycycline-based regulation of gene expression to modul ...

2002

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Bernard Schneider, Kristina Schoonjans, Graham Knott, Hao Li, Adrienne Joëlle Laurence Mottis, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Vera Monica Lemos Da Silva

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Claudia Kathe, Matthieu Pierre Gautier, Nicholas David James, Thomas Haynes Hutson, Michael Alexander Skinnider, Achilleas Laskaratos, Michael V. Sofroniew, Nicola Aldo Regazzi

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

Validation of Scalable and Compliant AAV Production

Florian Maria Wurm, Bernard Schneider, Nicole Déglon

Cell Press2017

Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

Bernard Schneider

There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN ...

2021

Gene therapy against amyotrophic lateral sclerosis: a bicistronic AAV vector for RNAi against mutated SOD1

Aline Aebi, Bernard Schneider, Philippe André Guy Colin, Pamela Solange Valdés Undurraga

MARY ANN LIEBERT, INC2022

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology

Bernard Schneider, Philippe André Guy Colin, Vanessa Laversenne

The brain pathology of Alzheimer’s disease (AD) is characterized by the misfolding and aggregation of both the amyloid beta (Aβ) peptide and hyperphosphorylated forms of the tau protein. Initial Aβ deposition is considered to trigger a sequence of deleteri ...

BioMed Central2020

Highlights of the cell transplantation meeting at Montreux, March 1999

Patrick Aebischer, Bernard Schneider

1999

Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells

Bernard Schneider, Pamela Solange Valdés Undurraga

Humana Press2024

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

Maria del Carmen Sandi Perez, Bernard Schneider, Olivia Zanoletti, Simone Astori, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Eva Ramos Fernandez, Elias Georges Gebara, Alessandro Chioino, Sriparna Ghosal

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...

2023

Cellular implants: pioneers in xenotransplantation?

Patrick Aebischer, Bernard Schneider

2003

TNFα prevents FGF4-mediated rescue of astrocyte dysfunction and reactivity in human ALS models

Bernard Schneider

Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis (ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central nervous system. Although astrocytes in ALS are known to be toxic to MNs, t ...

Elsevier BV2024

Encapsulation device

Bernard Schneider, Nicolas Bouche, Aurélien Lathuilière

Provided herein is a cell encapsulation device comprising an internal chamber suitable for holding biological agents, wherein the internal chamber is disposed between a first semipermeable layer and a second semi-permeable layer, and the first and second s ...

2016

Compositions and methods for delivering nucleic acids to cochlear and vestibular cells

Bernard Schneider, Paola Andrea Solanes Vega

Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. ...

2019

Allele-specific gene disruption through discrimination of a single base change by S. aureus Cas9-KKH prevents progressive hearing loss after AAV-mediated gene delivery

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

MARY ANN LIEBERT, INC2019

Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy

Bernard Schneider

Spinal muscular atrophy (SMA) is a neuromuscular disorder affecting young children. While pre-clinical models of SMA show small spleens, the same is not true in humans. Here, we show by doppler ultrasonography decreased splenic blood flow in Smn(2B/-) mice ...

2020

Neurotrauma treatment

Grégoire Courtine, Bernard Schneider, Jordan Squair, Mark Andrew Anderson

The invention provides pharmaceutical compositions, combinations and vectors, such as expression vectors, as well as use thereof in a method for central nervous system repair after neurotrauma, such as spinal cord injury (SCI) or stroke and in a method for ...

2024

Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease

Rolf Gruetter, Patrick Aebischer, Hongxia Lei, Bernard Schneider, Sharon Janssens, Lili Sun-Reimer

2011