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Paul Joseph Dyson

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Publications associées (669)

A cytotoxic ruthenium tris(bipyridyl) complex that accumulates at plasma membranes

Michael Graetzel, Horst Vogel, Shaik Mohammed Zakeeruddin, Paul Joseph Dyson, Christophe Danelon, Olivier Pierre Zava

Wiley-Blackwell2009

Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

Paul Joseph Dyson, Angela Casini

Electrospray ionisation mass spectrometry was used to analyze the reactions of metal compds. with mixts. of selected proteins. Three representative medicinally relevant compds., cisplatin, transplatin and the organometallic ruthenium compd. RAPTA-C, were r ...

Springer-Verlag2009

Trimetal-arene clusters with anticancer activity

Paul Joseph Dyson, Wee Han Ang

The invention relates to new medicaments, pharmaceutical compns. and methods of treatment of cancer. The invention discloses trimetallic clusters for use as a medicament, in particular in the treatment of cancer including metastasis. Preferably, the compds ...

2009

Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumour compounds with fluorinated arene ligands

Rosario Scopelliti, Paul Joseph Dyson, Ursula Röthlisberger, Enrico Marko Tapavicza, Andrew Douglas Phillips, Anna Katherine Renfrew

A series of compounds of general formula [Ru(eta(6)-fluoroarene)(pta)Cl-2] (fluoroarene = C6H5F, C6H5CF3, and 1,4-C6H4CH3F; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) have been prepared and characterized spectroscopically. Additionally, X-ray dif ...

American Chemical Society2009

Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Aldol reaction of allomaltol with arom. aldehydes, e.g., RC6H4CHO, R = H, 4-NO2, 4-F, 2-F and 3,4,5-(MeO)3C5H2CHO, gave 2-(hydroxyphenylmethyl)-3-hydroxy-6-methylpyran-4(1)-ones, maltol-derived ligands. Organometallic Ru(II)-arene complexes, [RuCl2(cymene) ...

2009

Design of ruthenium-based small molecules as potential therapeutic agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

This presentation will focus on research carried out in our labs. on organometallic compds. based on the ruthenium(II)-arene unit that exhibit promising in vitro and in vivo anticancer activity and potentially overcome the limitations of platinum based ant ...

2009

Influence of ion pairing on styrene hydrogenation using a cationic η6-arene β-diketiminato-ruthenium complex

Gabor Laurenczy, Paul Joseph Dyson, Andrew Douglas Phillips

A series of salts composed of the coordinatively unsatd. areneruthenium β-diketiminato cation and different anions, [(η6-C6H6)Ru(ArN:CMeCHCMe:NAr)][X] (1-4; Ar = 2,6-dimethylphenyl; X = OTf-, BF4-, PF6-, BPh4-) and [(η6-C6H6)Ru(ArN:CMeCHCMe:NAr)][BArF4] [5 ...

American Chemical Society2009

Synthesis, Molecular Structure, and Anticancer Activity of Cationic Arene Ruthenium Metallarectangles

Paul Joseph Dyson, Anna Katherine Renfrew

Cationic arene ruthenium-based tetranuclear complexes comprising rectangular structures have been obtained from the dinuclear arene ruthenium complexes [Ru2(arene)2(OO.intrsec.OO)2Cl2] (arene = p-cymene, hexamethylbenzene; OO.intrsec.OO = 2,5-dihydroxy-1,4 ...

American Chemical Society2009

"The Discovery, Use and Impact of Platinum Salts as Chemotherapy Agents for Cancer" WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE, Volume 30

Paul Joseph Dyson

2009

Selective Formic Acid Decomposition for High-Pressure Hydrogen Generation: A Mechanistic Study

Gabor Laurenczy, Céline Fellay, Paul Joseph Dyson, Ning Yan

A homogenous catalytic system has been developed that efficiently and selectively decomposes formic acid into hydrogen and carbon dioxide. [Ru(H2O)6]2+, [Ru(H2O)6]3+ and RuCl3·xH2O are all excellent precatalysts in presence of TPPTS (TPPTS=meta-trisulfonat ...

2009

Rational Design of an Organometallic Glutathione Transferase Inhibitor

Paul Joseph Dyson, Wee Han Ang

Double trouble: A hybrid org.-inorg. (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the org. moiety acts as the active-site inhibitor (see picture). The mechanism of inh ...

Wiley-VCH Verlag GmbH2009

Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]

Paul Joseph Dyson, Anna Katherine Renfrew

Pyridylferrocene and imidazolylferrocene arene-Ru complexes [Ru(η6-arene)(L)Cl2] where L = NC5H4CH2NHOCC5H4FeC5H5, arene = p-iPrC6H4Me (1) or C6Me6 (2); L = NC3H3N(CH2)2O2CC5H4FeC5H5, arene = p-iPrC6H4Me (3) or C6Me6 (4), and diruthenium-arene complexes [R ...

2009

Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds

Paul Joseph Dyson, Anna Katherine Renfrew

The rational development of multinuclear arene ruthenium complexes (arene = p-cymene, hexamethylbenzene) from generation 1 (G1) and generation 2 (G2) of 4-iminopyridyl based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)n (n = 4 or 8, DAB ...

Elsevier2009

A facile strategy for preparation of fluorescent SWNT complexes with high quantum yields based on ion exchange

Paul Joseph Dyson, Zhaofu Fei

The fluorescent imidazolium salt (1,3-bis(9-anthracenylmethyl)imidazolium chloride, [bamim]Cl) has been grafted onto the surfaces of single-walled carbon nanotubes (SWNTs) using an ion exchange strategy based on metathesis of the K+ ion in CO2K derivatized ...

2008

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research. Hydrolysis and DNA binding play an important role for pharmaceutical formulation and for exert ...

2008

Suzuki Coupling Reactions in Ether-Functionalized Ionic Liquids: The Importance of Weakly Interacting Cations

Paul Joseph Dyson, Zhaofu Fei, Andrew Douglas Phillips, Christian Hartinger, Yuehui Li, Xuemei Yang

Imidazolium- and pyridinium-based ionic liqs. with ether/polyether substituents have been evaluated as solvents for palladium-catalyzed Suzuki C-C coupling reactions. In general, reactions proceed more efficiently in these solvents compared to other ionic ...

2008

Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity

Paul Joseph Dyson, Wee Han Ang

Reaction of the dimers [Ru(h6-arene)Cl2]2 (arene = C6H6, C6H5Me, p-iPrC6H4Me, C6Me6) with 2 equiv of the ferrocenoyl pyridine (NC5H4(OOCC5H4FeC5H5)-4) affords Ru(II) complexes [Ru(h6-arene)Cl2(NC5H4OOCC5H4FeC5H5)] (arene = C6H6 (1, 85% yield), C6H5Me (2, 8 ...

2008

Hydrogen production from formic acid

Gabor Laurenczy, Céline Fellay, Paul Joseph Dyson

The present invention relates to a method of producing hydrogen gas and carbon dioxide in a catalytic reaction from formic acid, said reaction being conducted in an aqueous solution over a wide temperature range and already at room temperature (25 DEG C). ...

2008

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

Hisham Ben Hamidane, Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been used to probe the interaction of the anticancer drug cisplatin with oligonucleotides. The binding kinetics, the nature of the adducts formed, and the location of the binding s ...

2008

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

Kay Severin, Rosario Scopelliti, Paul Joseph Dyson, Claudine Scolaro, Barnali Dutta

The water-sol. complexes [(Cp'OR)RuCl(PTA)2] (Cp'OR = h5-1-alkoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl; R = Me, Et; PTA = 1,3,5-triaza-7-phosphaadamantane) are considerably more cytotoxic (.apprx.2 orders of magnitude) than the cyclopentadienyl an ...

2008

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