Jeffrey Alan Hubbell

Cette personne n’est plus à l’EPFL

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Publications associées (229)

PPS-PEG surface coating to reduce thrombogenicity of small diameter ePTFE vascular grafts

Jeffrey Alan Hubbell

Aims: Patency failure of small vascular synthetic grafts is still a major problem for coronary and peripheral revascularization. Thus, three new surface coatings of small synthetic grafts were tested in an acute pig model to evaluate their thrombogenicity ...

2005

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Matthias Lütolf, Jeffrey Alan Hubbell

A review. New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the regulatory characteristics of natural extracellular matrixes (ECMs) and ECM-bound growth facto ...

2005

Modified fibrin hydrogels stimulate angiogenesis in vivo: Potential application to increase perfusion of ischemic tissues

Jeffrey Alan Hubbell

The lack of angiogenesis in ischemic tissues is a major health problem and many studies aim to explore strategies to locally increase blood perfusion. Our approach is to use covalently modified fibrin-based hydrogels as a matrix that induces endothelial ce ...

2005

Molecularly engineered PEG hydrogels: A novel model system for proteolytically mediated cell migration

Matthias Lütolf, Jeffrey Alan Hubbell

Model systems mimicking the extracellular matrix (ECM) have greatly helped in quantifying cell migration in three dimensions and elucidated the mol. determinants of cellular motility in morphogenesis, regeneration, and disease progression. Here the authors ...

2005

Glucose sensitivity through oxidation responsiveness. An example of cascade-responsive nano-sensors

Nicola Tirelli, Annemie Rehor, Jeffrey Alan Hubbell

Oxidn.-sensitive nanoparticles have been decorated with an oxidizing enzyme (glucose oxidase) for release behavior that is responsive to the presence of the enzyme substrate (glucose). [on SciFinder (R)] ...

Royal Society of Chemistry2005

The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides

Matthias Lütolf, Jeffrey Alan Hubbell

The ability of the biomimetic peptides YIGSR, PHSRN and RGD to selectively affect adhesion and migration of human microvascular endothelial cells (MVEC) and vascular smooth muscle cells (HVSMC) was evaluated. Cell mobility was quantified by time-lapse vide ...

2005

Biomolecular patterning vika photocatalytic lithography

Jeffrey Alan Hubbell

We have developed a novel method for patterning surface chem.: Photocatalytic Lithog. This technique relies on inexpensive stamp materials and light; it does not necessitate mass transport or specified substrates, and the wavelength of light should not lim ...

2005

3D morphology of cell cultures: a quantitative approach using micrometer synchrotron light tomography

Randoald Müller, Jeffrey Alan Hubbell

Current issues in both tissue engineering and cell biology deal with cell behavior extensively in 3D. Here, we explore synchrotron radiation micro-computed tomography as a tool for morphological characterization of such 3D cellular constructs, providing mi ...

2005

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

Patrick Aebischer, Jeffrey Alan Hubbell

Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor XIIIa was employed to covalently incorporate exogenous bioactive peptides within fibrin during c ...

2000

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