Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

Oxford University Press2021

Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients

Nicolas Jean Philippe Guex, Nathalie Rufer, Mauro Delorenzi, Mathieu Quinodoz

2021

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome

Nicolas Jean Philippe Guex, Pasquelena De Nittis

2021

Predicting spatial patterns of soil bacteria under current and future environmental conditions

Nicolas Jean Philippe Guex, Jan Roelof van der Meer, Marco Pagni, Aline Buri

Soil bacteria are largely missing from future biodiversity assessments hindering comprehensive forecasts of ecosystem changes. Soil bacterial communities are expected to be more strongly driven by pH and less by other edaphic and climatic factors. Thus, al ...

2021

A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root

Nicolas Jean Philippe Guex, Julien Dorier

2021

Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

Nicolas Jean Philippe Guex, Marco Pagni, Anne Wilson, Aurélien Thomas, Tiziana Caputo

2021

Blood virosphere in febrile Tanzanian children

Christian Iseli, Thomas Junier, Nicolas Jean Philippe Guex, Mary-Anne Hartley, Jacques Fellay

Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine s ...

2021

Greater topoclimatic control of above‐ versus below‐ground communities

Nicolas Jean Philippe Guex, Enrique Lara, Edward Mitchell, Marco Pagni, Aline Buri, Loïc Pellissier

2020

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

Christian Iseli, Nicolas Jean Philippe Guex, Noémie Matthey, Melanie Blokesch, Candice Stoudmann, Sandrine Stutzmann

Natural competence for transformation is a primary mode of horizontal gene transfer. Competent bacteria are able to absorb free DNA from their surroundings and exchange this DNA against pieces of their own genome when sufficiently homologous. However, the ...

2019

Differential regulation of RNA polymerase III genes during liver regeneration

Felix Naef, Philippe Jacquet, Nicolas Jean Philippe Guex, Jonathan Aryeh Sobel, Cristian Carmeli, Olivier Martin, Irina Krier, Mauro Delorenzi, Nouria Hernandez, Bart Deplancke, Jacques Rougemont, François Mange, Laura Symul, Fabrice David, Sunil Kumar Raghav, Julien Delafontaine, Marion Leleu, Julia Catharina Cajan, Winship Herr, Kyle Gustafson, Maykel Lopes, Dominic Villeneuve, Ioannis Xenarios

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...

Oxford University Press (OUP)2019

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

Nicolas Jean Philippe Guex, Miguel Garcia, Nadine Fournier, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Gael Luis Boivin, Ioannis Xenarios, Inti Zlobec

AMER ASSOC CANCER RESEARCH2018

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Miguel Garcia, Nadine Fournier, Etienne Meylan, Loïc Steiner, Alessandra Piersigilli, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Gael Luis Boivin, Ioannis Xenarios, Inti Zlobec

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

Nicolas Jean Philippe Guex, Luc Henry, Nathalie Rufer, Emanuela Marina Iancu, Hans-Anton Lehr, George Coukos, Ioannis Xenarios

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...

Taylor & Francis Inc2016

Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain

Nicolas Jean Philippe Guex, Pascal Escher

NR2E3 encodes the photoreceptor-specific nuclear hormone receptor that acts as a repressor of cone-specific gene expression in rod photoreceptors, and as an activator of several rod-specific genes. Recessive variants located in the ligand-binding domain (L ...

Wiley-Blackwell2015

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Gerardo Turcatti, Marc Chambon, Nicolas Jean Philippe Guex, Olivier Martin

The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...

Nature Publishing Group2015

Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Felix Naef, Nicolas Jean Philippe Guex, Olivier Martin, Mauro Delorenzi, Nouria Hernandez, Bart Deplancke, Jacques Rougemont, Laura Symul, Winship Herr

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Nicolas Jean Philippe Guex, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Julie Deuquet Ariosa, Suzanne Salvi

Hyaline Fibromatosis Syndrome (HIS) is a human genetic disease caused by mutations in the anthrax toxin receptor 2 (or cmg2) gene, which encodes a membrane protein thought to be involved in the homeostasis of the extracellular matrix. Little is known about ...

Wiley Open Access2011

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