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Nicolas Jean Philippe Guex

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Related publications (40)

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Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

Felix Naef, Nicolas Jean Philippe Guex, Olivier Martin, Mauro Delorenzi, Bart Deplancke, Jacques Rougemont, Laura Symul

Interactions of cell-autonomous circadian oscillators with diurnal cycles govern the temporal compartmentalization of cell physiology in mammals. To understand the transcriptional and epigenetic basis of diurnal rhythms in mouse liver genome-wide, we gener ...

Public Library Science2012

DNA modifications impact natural transformation of Acinetobacter baumannii

Christian Iseli, Nicolas Jean Philippe Guex, Melanie Blokesch, Nina Vesel, Alexandre Lemopoulos

Acinetobacter baumannii is a dangerous nosocomial pathogen, especially due to its ability to rapidly acquire new genetic traits, including antibiotic resistance genes (ARG). In A. baumannii, natural competence for transformation, one of the primary modes o ...

2023

Mechanopathology of biofilm-like Mycobacterium tuberculosis cords

Nicolas Jean Philippe Guex, Graham Knott, John McKinney, Neeraj Dhar, Jessica Sordet, Maxime Jan, Kunal Sharma, Mélanie Thérèse Marie Hannebelle, Vivek Vijay Thacker, Anaëlle Fabienne Dubois, Richa Mishra, Maria Gabriela Kirsch

Mycobacterium tuberculosis (Mtb) cultured axenically without detergent forms biofilm-like cords, a clinical identifier of virulence. In lung-on-chip (LoC) and mouse models, cords in alveolar cells contribute to suppression of innate immune signaling via nu ...

Cell Press2023

Differential regulation of RNA polymerase III genes during liver regeneration

Felix Naef, Philippe Jacquet, Nicolas Jean Philippe Guex, Jonathan Aryeh Sobel, Cristian Carmeli, Olivier Martin, Irina Krier, Mauro Delorenzi, Bart Deplancke, Jacques Rougemont, Laura Symul, Fabrice David, Sunil Kumar Raghav, Marion Leleu, Julia Catharina Cajan, Kyle Gustafson, Dominic Villeneuve

Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcriptio ...

Oxford University Press (OUP)2019

SPICA: Swiss portal for immune cell analysis

Christian Iseli, Nicolas Jean Philippe Guex

Single-cell transcriptomics allows the study of immune cell heterogeneity at an unprecedented level of resolution. The Swiss portal for immune cell analysis (SPICA) is a web resource dedicated to the exploration and analysis of single-cell RNA-seq data of ...

OXFORD UNIV PRESS2022

Predicting spatial patterns of soil bacteria under current and future environmental conditions

Nicolas Jean Philippe Guex

Soil bacteria are largely missing from future biodiversity assessments hindering comprehensive forecasts of ecosystem changes. Soil bacterial communities are expected to be more strongly driven by pH and less by other edaphic and climatic factors. Thus, al ...

2021

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Gerardo Turcatti, Marc Chambon, Nicolas Jean Philippe Guex, Olivier Martin

The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...

Nature Publishing Group2015

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

Nicolas Jean Philippe Guex, Miguel Garcia, Nadine Fournier, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Gael Luis Boivin

AMER ASSOC CANCER RESEARCH2018

DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies

Nicolas Jean Philippe Guex, Cristian Carmeli, Murielle Bochud

As a powerful phenotyping technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory effect in various biological processes. While ...

Nature Research2021

Greater topoclimatic control of above‐ versus below‐ground communities

Nicolas Jean Philippe Guex, Enrique Lara, Valeria Di Cola Bucciarelli

2020

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome

Nicolas Jean Philippe Guex, Pasquelena De Nittis

2021

Unexpected post‐glacial colonisation route explains the white colour of barn owls ( Tyto alba ) from the British Isles

Christian Iseli, Nicolas Jean Philippe Guex

The climate fluctuations of the Quaternary shaped the movement of species in and out of glacial refugia. In Europe, the majority of species followed one of the described traditional postglacial recolonization routes from the southern peninsulas towards the ...

2022

Comparative assessment of cytometry by time-of-flight and full spectral flow cytometry based on a 33-color antibody panel

Nicolas Jean Philippe Guex, Julien Dorier, Miguel Garcia

Mass cytometry and full spectrum flow cytometry have recently emerged as new promising single cell proteomic analysis tools that can be exploited to decipher the extensive diversity of immune cell repertoires and their implication in human diseases. In thi ...

Elsevier2024

Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery

Nicolas Jean Philippe Guex, Fabrizio Benedetti, George Coukos, Alexandre Harari

2021

Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy

Nicolas Jean Philippe Guex

2021

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

Nicolas Jean Philippe Guex

2021

Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients

Nicolas Jean Philippe Guex, Mauro Delorenzi

2021

Nicolas Jean Philippe Guex

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Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles

DNA modifications impact natural transformation of Acinetobacter baumannii

Mechanopathology of biofilm-like Mycobacterium tuberculosis cords

Differential regulation of RNA polymerase III genes during liver regeneration

SPICA: Swiss portal for immune cell analysis

Predicting spatial patterns of soil bacteria under current and future environmental conditions

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

DBnorm as an R package for the comparison and selection of appropriate statistical methods for batch effect correction in metabolomic studies

Greater topoclimatic control of above‐ versus below‐ground communities

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome

Unexpected post‐glacial colonisation route explains the white colour of barn owls ( Tyto alba ) from the British Isles

Comparative assessment of cytometry by time-of-flight and full spectral flow cytometry based on a 33-color antibody panel

Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery

A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root

Molecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach

Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients