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Denis Duboule

Cette personne a quitté l’EPFL

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Publications associées (58)

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Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

Denis Duboule

During the development of mammalian digits, clustered Hoxd genes are expressed following a collinear regulatory strategy, leading to both the growth of digits and their morphological identities. Because gene dosage is a key parameter in this system, we use ...

2008

Chromatin looping and organization at developmentally regulated gene loci

Denis Duboule

Developmentally regulated genes are often controlled by distant enhancers, silencers and insulators, to implement their correct transcriptional programs. In recent years, the development of 3C and derived techniques (4C, 5C, HiC, ChIA- PET, etc.) has confi ...

2013

Comments on the Hox timer and related issues

Denis Duboule, Hocine Rekaik

In particular, this sequence is found in the 39 members of the amniote Hox gene family, a series of genes activated in mid-gastrulation and involved in organizing morphologies along the extending anterior to posterior (AP) body axis. Over the past 30 years ...

2025

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Denis Duboule, Anamaria Necsulea, Nicolas Lonfat

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets ...

Cold Spring Harbor Laboratory2016

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Denis Duboule, Fabrice Daniel Darbellay, Anamaria Necsulea

During embryonic development, Hox genes participate in the building of a functional digestive system in metazoans, and genetic conditions involving these genes lead to important, sometimes lethal,growth retardation. Recently, this phenotype was obtained af ...

National Academy of Sciences2017

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

Denis Duboule, Nicolas Lonfat

Hox genes encode transcription factors necessary for patterning the major developing anterior to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of this gene family were co-opted along with the emergence of novel body st ...

Elsevier2015

Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

Denis Duboule

During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory switch, bringing tail bud progenitors under Gdf11 signaling control. Gdf11 mutant embryos have an ...

Cell Press - Elsevier2019

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Denis Duboule, Fabrice Daniel Darbellay

Hox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was ...

Elsevier Academic Press Inc2016

Commentary on paper by Leroy C. Stevens (1960)

Denis Duboule

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

A genetic approach of long-range gene regulation during development and evolution

Denis Duboule

Springer2016

Chromatin topology and the timing of enhancer function at the HoxD locus

Denis Duboule, Lucille Delisle

The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that organizes digits. These two regulations are e ...

National Academy of Sciences2020

Hox Genes Regulation During Vertebrate Development and Evolution

Denis Duboule, Fabrice Daniel Darbellay

Elsevier Science Bv2017

Considerations when investigating IncRNA function in vivo

Denis Duboule

Although a small number of the vast array of animal long non-coding RNAs (IncRNAs) have known effects on cellular processes examined in vitro, the extent of their contributions to normal cell processes throughout development, differentiation and disease fo ...

Elife Sciences Publications Ltd2014

Do RET somatic mutations play a role in Hirschsprung disease? Response

Denis Duboule

NATURE PUBLISHING GROUP2018

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

Denis Duboule, Lucille Delisle, Guillaume Andrey, Christopher Chase Bolt

In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then the dis ...

PUBLIC LIBRARY SCIENCE2018

Nanoscale Spatial Organization of Chromatin in its Cellular Context, from Telomeres to Hox

Denis Duboule, Suliana Manley, Joachim Lingner, Kyle Michael Douglass, Aleksandr Benke, Verena Pfeiffer, Aleksandra Vancevska

Cell Press2016

Conserved elements within open reading frames of mammalian Hox genes

Denis Duboule

A recent study in BMC Evolutionary Biology shows that many of the open reading frames in mammalian Hox genes are more conserved than expected on the basis of their protein sequence. The presence of highly conserved DNA elements is thus not confined to the ...

2009

SnapShot: Hox Gene Regulation

Denis Duboule, Guillaume Andrey

Elsevier2014