Recherche

Afficher tous les résultats pour

Accueil

Personne

Denis Duboule

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (60)

Do RET somatic mutations play a role in Hirschsprung disease? Response

Denis Duboule

NATURE PUBLISHING GROUP2018

Similarities and differences in the regulation of HoxD genes during chick and mouse limb development

Denis Duboule, Guillaume Andrey, Leonardo Beccari, Nayuta Yakushiji, Christopher Chase Bolt, Lucille Delisle

In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then the dis ...

PUBLIC LIBRARY SCIENCE2018

Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development

Denis Duboule, Marion Leleu, Pierre Raymond Fabre

Background: Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumental to ensure the proper formation ...

2018

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes

Denis Duboule, Pierre Raymond Fabre, Leonardo Beccari, Lucille Delisle, Edgardo Rodriguez Carballo

The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the telomeric TAD controls the early transcription of Hoxd genes in forearm cells, whereas ...

2017

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Denis Duboule, Fabrice Daniel Darbellay, Anamaria Necsulea, Jozsef Zakany

During embryonic development, Hox genes participate in the building of a functional digestive system in metazoans, and genetic conditions involving these genes lead to important, sometimes lethal,growth retardation. Recently, this phenotype was obtained af ...

National Academy of Sciences2017

Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells

Denis Duboule, Patrick Schorderet, Guillaume Andrey, Nayuta Yakushiji

During embryonic development, fields of progenitor cells form complex structures through dynamic interactions with external signaling molecules. How complex signaling inputs are integrated to yield appropriate gene expression responses is poorly understood ...

National Academy of Sciences2017

Hox Genes Regulation During Vertebrate Development and Evolution

Denis Duboule, Fabrice Daniel Darbellay, Jozsef Zakany

Elsevier Science Bv2017

Large scale genomic reorganization of topological domains at the HoxD locus

Denis Duboule, Daniël Noordermeer, Marion Leleu, Pierre Raymond Fabre, Leonardo Beccari, Benjamin Howard Mormann, Lucille Delisle

BACKGROUND: The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD g ...

2017

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Denis Duboule

Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with larg ...

2017

A genetic approach of long-range gene regulation during development and evolution

Denis Duboule

Springer2016

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Denis Duboule, Fabrice Daniel Darbellay

Hox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was ...

Elsevier Academic Press Inc2016

Nanoscale Spatial Organization of Chromatin in its Cellular Context, from Telomeres to Hox

Denis Duboule, Joachim Lingner, Suliana Manley, Verena Pfeiffer, Aleksandr Benke, Pierre Raymond Fabre, Aleksandra Vancevska, Kyle Michael Douglass

Cell Press2016

Hotair Is Dispensible for Mouse Development

Denis Duboule, Anamaria Necsulea

Despite the crucial importance of Hox genes functions during animal development, the mechanisms that control their transcription in time and space are not yet fully understood. In this context, it was proposed that Hotair, a lncRNA transcribed from within ...

Public Library Science2016

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Denis Duboule, Virginie Marcet, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Jozsef Zakany

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...

National Academy of Sciences2016

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Denis Duboule, Nicolas Lonfat, Leonardo Beccari, Anamaria Necsulea, Nayuta Yakushiji, Edgardo Rodriguez Carballo

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets ...

Cold Spring Harbor Laboratory2016

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Denis Duboule

Within land vertebrate species, snakes display extreme variations in their body plan, characterized by the absence of limbs and an elongated morphology. Such a particular interpretation of the basic vertebrate body architecture has often been associated wi ...

Elife Sciences Publications Ltd2016

Structure, function and evolution of topologically associating domains (TADs) at HOX loci

Denis Duboule, Nicolas Lonfat

Hox genes encode transcription factors necessary for patterning the major developing anterior to posterior embryonic axis. In addition, during vertebrate evolution, various subsets of this gene family were co-opted along with the emergence of novel body st ...

Elsevier2015

Visualizing the HoxD Gene Cluster at the Nanoscale Level

Denis Duboule, Suliana Manley, Aleksandr Benke, Pierre Raymond Fabre

Transcription of HoxD cluster genes in limbs is coordinated by two topologically associating domains (TADs), neighboring the cluster and containing various enhancers. Here, we use a combination of microscopy approaches and chromosome conformation capture t ...

2015

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model

Denis Duboule

The tetrapod vertebral column has become increasingly complex during evolution as an adaptation to a terrestrial life. At the same time, the evolution of the vertebral formula became subject to developmental constraints acting on the size of the cervical a ...

Elsevier2015

Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states

Denis Duboule, Suliana Manley, Aleksandr Benke, Pierre Raymond Fabre

Chromatin condensation plays an important role in the regulation of gene expression. Recently, it was shown that the transcriptional activation of Hoxd genes during vertebrate digit development involves modifications in 3D interactions within and around th ...

2015

Page 2 sur 3