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Patric Hagmann

Cette personne a quitté l’EPFL

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Publications associées (90)

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Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers

Patric Hagmann, Pascal Hagmann

MRI tractography is the mapping of neural fiber pathways based on diffusion MRI of tissue diffusion anisotropy. Tractography based on diffusion tensor imaging (DTI) cannot directly image multiple fiber orientations within a single voxel. To address this li ...

Elsevier2008

Resting-State Temporal Synchronization Networks Emerge from Connectivity Topology and Heterogeneity

Patric Hagmann

Spatial patterns of coherent activity across different brain areas have been identified during the resting-state fluctuations of the brain. However, recent studies indicate that resting-state activity is not stationary, but shows complex temporal dynamics. ...

Public Library Science2015

Sensorimotor Induction of Auditory Misattribution in Early Psychosis

Olaf Blanke, Patric Hagmann, Alessandra Griffa, Andrea Serino, Giulio Rognini, Roy Salomon, Fosco Bernasconi, Silvia Marchesotti

Dysfunction of sensorimotor predictive processing is thought to underlie abnormalities in self-monitoring producing passivity symptoms in psychosis. Experimentally induced sensorimotor conflict can produce a failure in bodily self-monitoring (presence hall ...

2020

Holographic Visualisation and Interaction of Fused CT, PET and MRI Volumetric Medical Imaging Data Using Dedicated Remote GPGPU Ray Casting

Patric Hagmann, Stéphane Gobron, Adrien Raphaël Depeursinge

Medical experts commonly use imaging including Computed Tomography (CT), Positron-Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) for diagnosis or to plan a surgery. These scans give a highly detailed representation of the patient anatomy, b ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Rolf Gruetter, Patric Hagmann, Lijing Xin, Alessandra Griffa

Background: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, ...

Oxford University Press (OUP)2019

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

Rolf Gruetter, Lijing Xin, Alessandra Griffa, Patric Hagmann

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side e ...

2018

Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

Dimitri Nestor Alice Van De Ville, Patric Hagmann, Maria Giulia Preti

Objective: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). ...

ELSEVIER IRELAND LTD2023

Mapping Human Whole-Brain Structural Networks with Diffusion MRI

Jean-Philippe Thiran, Patrick Thiran, Patric Hagmann, Reto Meuli, Xavier Gigandet, Maciej Kurant

Understanding the large-scale structural network formed by neurons is a major challenge in system neuroscience. A detailed connectivity map covering the entire brain would therefore be of great value. Based on diffusion MRI, we propose an efficient methodo ...

2007

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Jean-Philippe Thiran, Rolf Gruetter, Patric Hagmann, Lijing Xin, Alessandra Griffa, Philipp Baumann

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

Nature Publishing Group2015

Dynamic spatiotemporal patterns of brain connectivity reorganize across development

Patric Hagmann, Alessandra Griffa, Marie Schaer

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying wh ...

MIT PRESS2020

In-vivo probabilistic atlas of human thalamic nuclei based on diffusion-weighted magnetic resonance imaging

Jean-Philippe Thiran, Meritxell Bach Cuadra, Patric Hagmann, Maxime Descoteaux

The thalamic nuclei are involved in many neurodegenerative diseases and therefore, their identification is of key importance in numerous clinical treatments. Automated segmentation of thalamic subparts is currently achieved by exploring diffusion-weighted ...

NATURE PUBLISHING GROUP2018

Adaptive Strategy for the Statistical Analysis of Connectomes

Jean-Philippe Thiran, Reto Meuli, Patric Hagmann, Stephan Morgenthaler, Leila Cammoun, Djalel Eddine Meskaldji, Leila Faiza Ben Hamida Cammoun

We study an adaptive statistical approach to analyze brain networks represented by brain connection matrices of interregional connectivity (connectomes). Our approach is at a middle level between a global analysis and single connections analysis by conside ...

Public Library of Science2011

Robust T1-Weighted Structural Brain Imaging and Morphometry at 7T Using MP2RAGE

Tobias Kober, Patric Hagmann, José Pedro Rebelo Ferreira Marques, Gunnar Krüger, François Lazeyras, Alexis Roche, Kieran O'Brien

Purpose To suppress the noise, by sacrificing some of the signal homogeneity for numerical stability, in uniform T1 weighted (T1w) images obtained with the magnetization prepared 2 rapid gradient echoes sequence (MP2RAGE) and to compare the clinical utilit ...

Public Library of Science2014

How much confidence do we have in a MRI tractography experiment?

Jean-Philippe Thiran, Reto Meuli, Patric Hagmann, Xavier Gigandet

When performing a tractography experiment it is essential to know whether a reconstructed tract results from the diffusion signal itself or from some random effect or noise. In this study, we introduce a way to associate to every connection a confidence le ...

IEEE2007

Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Patric Hagmann, Stephan Morgenthaler, Djalel Eddine Meskaldji, David Paul Roger Romascano

Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase ...

Elsevier2015

Intrahemispheric cortico-cortical connections of the human auditory cortex

Jean-Philippe Thiran, Reto Meuli, Patric Hagmann, Alessandra Griffa, Leila Cammoun, Leila Faiza Ben Hamida Cammoun, Stephanie Clarke

The human auditory cortex comprises the supratemporal plane and large parts of the temporal and parietal convexities. We have investigated the relevant intrahemispheric cortico-cortical connections using in vivo DSI tractography combined with landmark-base ...

Springer Heidelberg2015

Exploring the role of white matter connectivity in cortex maturation

Patric Hagmann, Alessandra Griffa

The maturation of the cortical gray matter (GM) and white matter (WM) are described as sequential processes following multiple, but distinct rules. However, neither the mechanisms driving brain maturation processes, nor the relationship between GM and WM m ...

2017

Flow simulation and hemolysis modeling for a blood centrifuge device

Mark Sawley, Michel Deville, Patric Hagmann

A common blood separation technique is to accelerate the sedimentation of blood constituents by centrifugation and then collect these constituents separately. When subjected to conditions of excessive stress, hemolysis can however occur, whereby the membra ...

Pergamon-Elsevier Science Ltd2013

White matter maturation reshapes structural connectivity in the late developing human brain

Jean-Philippe Thiran, Patric Hagmann, Reto Meuli, Leila Cammoun, Leila Faiza Ben Hamida Cammoun

From toddler to late teenager, the macroscopic pattern of axonal projections in the human brain remains largely unchanged while undergoing dramatic functional modifications that lead to network refinement. These functional modifications are mediated by inc ...

National Academy of Sciences2010

A multi-scale probabilistic atlas of the human connectome

Meritxell Bach Cuadra, Patric Hagmann, Alessandra Griffa, Maxime Descoteaux

The human brain is a complex system that can be efficiently represented as a network of structural connectivity. Many imaging studies would benefit from such network information, which is not always available. In this work, we present a whole-brain multi-s ...

NATURE PORTFOLIO2022