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Pierre Vogel

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Publications associées (99)

Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides

Pierre Vogel, Jianfei Bai

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2-ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic ...

Amer Chemical Soc2014

Amide Formation in One Pot from Carboxylic Acids and Amines via Carboxyl and Sulfinyl Mixed Anhydrides

Pierre Vogel, Dean Markovic

An efficient method has been developed for the preparation of yet unknown acyclic mixed anhydrides of carboxylic and sulfinic acids. Sterically hindered 2-methylbut-3-ene-2-sulfinyl carboxylates add primary and secondary amines preferentially onto the carb ...

Amer Chemical Soc2013

Review of Particle Physics, Particle Data Group

Pierre Vogel, Christophe Bauer, Olivier Schneider, Greig Alan Cowan

This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2658 new measurements from 644 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We summarize ...

American Physical Society2012

Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866

Pierre Vogel, Annabelle Gillig, Bernard Sordat, Somi Reddy Majjigapu

FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C-iminoribofuranoside analog (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hyd ...

Wiley-VHCA AG2012

Synthesis of 2-(1-aminocyclopropyl)pyrrolidine-3,4-diol derivatives applying titanium-mediated reaction conditions

Pierre Vogel, Claudia Bello

The titanium-mediated cyclopropanation reaction using Ti((OPr)-Pr-i)(3)Me/EtMgBr/BF3 center dot OEt2 has been applied to various 2-cyanopyrrolidines for the synthesis of functionalized 2-(1-aminocyclopropyl)pyrrolidine-3,4-diol derivatives (dideoxyiminoald ...

2012

A C-Linked Disaccharide Analogue of Thomsen-Friedenreich Epitope Induces a Strong Immune Response in Mice

Pierre Vogel, Loay Awad, Maria Kolympadi, Annabelle Gillig, Andreas Muhs

2012

Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

Pierre Vogel, Sylvain Favre

Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated a ...

2012

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Pierre Vogel, Olivier Michielin, Somi Reddy Majjigapu

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used co ...

2012

Efficient Asymmetric Synthesis of Long-Chain Polyketides Containing up to Ten Contiguous Stereogenic Centres by Double Chain Elongation

Pierre Vogel, Rosario Scopelliti, Maris Turks

The 2,3-anti-3,4-syn-stereotriad (1Z,2S,3R,4S)-1-ethylidene-2,4-dimethyl-3-[(1S)-1-phenylethoxy]-5-oxopent-1-yl isobutyrate {(-)-8, obtained in a one-pot operation from the trimethylsilyl (Z)-enol ether derived from pentan-3-one and (1E,3Z)-1[(1S)-phenylet ...

2011

Concise Synthesis of Complicated Polypropionates through One-Pot Dissymmetrical Two-Directional Chain Elongation

Pierre Vogel, Maris Turks, Freddy Fonquerne, Claudia Jana Exner

Herein, a major breakthrough in a sulfur dioxide-mediated oxyallylation cascade reaction is reported that allows the preparation of complex long-chain polyketide fragments with more than ten stereogenic centers through a carefully designed desymmetrization ...

2011

Total Asymmetric Syntheses of beta-Hydroxy-delta-lactones via Umpolung with Sulfur Dioxide

Pierre Vogel, Maris Turks, Sylvain Claude Laclef, Claudia Jana Exner, Florent Poli

Cyclic stereotriads and stereotetrads of the beta-hydroxy-delta-lactone type, e.g. prelactones B and E, common in polyketides and polypropionates, are prepared via SO2-induced oxyallylations of enoxysilanes with (1E,3Z)-1-(1-phenylethoxy)penta-1,3-dien-3-y ...

2011

Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Pierre Vogel, Claudia Bello, Bernard Sordat, Marc Dupuis

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-Dribitol (13, IC50 similar to 2 mu M) and its C-18-analo ...

2011

The norbornene mystery revealed

Pierre Vogel, Anne-Clémence Corminboeuf

The long-standing mystery surrounding the peculiar electronic structure of norbornene and its derivatives is revealed by the direct comparisons of their properties with those of reference analogues with localized double bonds (i.e. Lewis structures). Our b ...

Royal Society of Chemistry2011

Glycochemistry Today

Pierre Vogel

2011

Synthetic studies toward the CD spiroketal of spongistatins

Pierre Vogel, Sandrine Gerber, Sylvain Favre

Starting from the readily available meso-methylenedi(8-oxa-3-oxobicyclo[3.2.1]hept-6-en-1-yl) (1), meso-1,1'-methylidene [(4R,4'S,6R,6'S)-4,6-dioxycyclohept-1-en-1-yl]tetrasilylethers (7, 8) were obtained and transformed into all-syn 1,3,5,11,13,15-hexahyd ...

Wiley-Blackwell2010

Novel dihydroxypyrrolidine derivatives as anti-cancer agents

Pierre Vogel, Claudia Bello

The present invention provides new dihydroxypyrrolidine derivatives for use as medicaments. The compounds are useful in the treatment in cancer, in particular non-solid neoplasms. ...

2010

Total Synthesis and Determination of the Absolute Configuration of (-)-Dolabriferol

Pierre Vogel, Maris Turks, Sylvain Claude Laclef

Wiley-VCH Verlag GmbH2010

Short Diastereoselective Synthesis of the C1-C13 (AB Spiroacetal) and C17-C28 Fragments (CD Spiroacetal) of Spongistatin 1 and 2 through Double Chain-Elongation Reactions

Pierre Vogel, Christopher Flowers

A unique and practical synthetic sequence for rapid access to polyketides and to further the spiroacetals derived from them, which utilizes a bidirectional Hosomi-Sakurai allylation approach around key allylsilanes in the synthesis of the AB and CD ring sy ...

2010

The Catalyzed Desulfinylative Allylation of Carbonyl Compounds with Alk-2-enesulfonyl Chlorides and Silyl Alk-2-enesulfinates

Pierre Vogel, Dean Markovic, Sylvain Claude Laclef, Chandra Mouleeswara Rao Volla

2010

The regioselectivity of the addition of benzeneselenyl chloride to 7-azanorborn-5-ene-2-yl derivatives is controlled by the 2-substituent: new entry into 3-and 4-hydroxy-5-substituted prolines

Pierre Vogel, Inmaculada Robina, Agostina Ruggiu

The electrophilic addition of benzeneselenyl chloride to the alkene moiety of 7-azabicyclo[2.2.1]hept-5en-2-yl derivatives has been studied. With camphanates 8 and 9 N-Boc-5-endo-chloro-6-exo-phenylseleno-7-azanorborn-2-yl camphanates 10 and 11 are obtaine ...

2010

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