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André Merbach

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Publications associées (40)

First in vivo MRI assessment of a self-assembled metallostar compound endowed with a remarkable high field relaxivity

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

{Fe[Gd2bpy(DTTA)2(H2O)4]3}4- is a self-assembled, metallostar-structured potential MRI contrast agent, with six efficiently relaxing Gd3+ centers confined into a small mol. space. Its proton relaxivity is particularly remarkable at very high magnetic field ...

2006

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

André Merbach, Lothar Helm, Eva Jakab Toth, Petra Lebduskova

A DTPA-based chelate containing one phosphinate group was conjugated to a generation 5 polyamidoamine (PAMAM) dendrimer via a benzylthiourea linkage. The Gd(III) complex of this novel conjugate has potential as a contrast agent for magnetic resonance imagi ...

2006

A Starburst-Shaped Heterometallic Compound Incorporating Six Densely Packed Gd3+ Ions

André Merbach, Alain Borel, Eva Jakab Toth, Joao Bruno Livramento Fig.

The heterotritopic ligand [bpy(DTTA)2]8- has two diethylenediamine-tetraacetate units for selective lanthanide(III) coordination and one bipyridine function for selective FeII coordination. In aqueous solution and in the presence of these metals, the ligan ...

2006

Isomerization mechanisms of a labile Co(II) octahedral complex

André Merbach, Lothar Helm, Fabrice Riblet

The labile cobalt (II) complex [Co(TUF)2(Pic)2] with 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (TUF) bidentate and 4-methylpyridine (Pic) monodentate ligands was studied by variable temp. (VT) 19F NMR from 184 to 312 K. In contrast to the solid state, ...

2006

Unexpected Aggregation of Neutral, Xylene-Cored Dinuclear GdIII Chelates in Aqueous Solution

André Merbach, Lothar Helm, Eva Jakab Toth, Jéröme Costa

2006

Separation and Characterization of the Two Diastereomers for [Gd(DTPA-bz-NH2)(H2O)]2-, a Common Synthon in Macromolecular MRI Contrast Agents: Their Water Exchange and Isomerization Kinetics

André Merbach, Eva Jakab Toth

2005

Synthesis and complexation properties of DTPA-N,N"-bis[bis(n-butyl)]-N'-methyl-tris(amide). Kinetic stability and water exchange of its Gd3+ complex

André Merbach, Eva Jakab Toth

2005

Water and proton Exchange Processes on Metal Ions

André Merbach, Lothar Helm, Gaëlle Nicolle

2005

Rigid M(II)L2Gd(III)2 (M=Fe, Ru) Complexes of a Terpyridine-Based Heteroditopic Chelate: A Class of Candidates for MRI Contrast Agents

André Merbach, Lothar Helm, Jéröme Costa

2005

Reactivity of the novel organometallic aqua-ion [(CO)2(NO)Re(H2O) 3]2+: Kinetics of H2O substitution and 17O exchange of CO ligands

André Merbach, Pascal Grundler, Marie-Line Lehaire

2005

Rotational Dynamics Account for pH-Dependent Relaxivities of PAMAM Dendrimeric, Gd-Based Potential MRI Contrast Agents

André Merbach, Eva Jakab Toth, Sabrina Laus

The EPTPA5- chelate, which ensures fast water exchange in GdIII complexes, has been coupled to three different generations (5, 7, and 9) of polyamidoamine (PAMAM) dendrimers through benzylthiourea linkages (H5EPTPA=ethylenepropylenetriamine-N,N,N,N,N-penta ...

2005

Fine-tuning water exchange on GdIII poly(amino carboxylates) by modulation of steric crowding

André Merbach, Eva Jakab Toth

2005

Lanthanide(III) chelates of DTPA bis(amide) glycoconjugates: potential imaging agents targeted at the asyaloglycoprotein receptor

André Merbach, Eva Jakab Toth

2005

Dinuclear, Bishydrated GdIII Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton Relaxivities

André Merbach, Lothar Helm, Eva Jakab Toth, Jéröme Costa

2005

Water-Soluble Gadofullerenes: Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

André Merbach, Lothar Helm, Alain Borel, Eva Jakab Toth

The water-soluble endohedral gadofullerene derivatives, Gd@C60(OH)x and Gd@C60[C(COOH)2]10, have been characterized with regard to their MRI contrast agent properties. Water-proton relaxivities have been measured in aqueous solution at variable temperature ...

2005

High Relaxivity Confined to a Small Molecular Space: A Metallostar-Based, Potential MRI Contrast Agent

André Merbach, Alain Borel, Eva Jakab Toth, Joao Bruno Livramento Fig.

Good things come in small packages: For its moderate molecular weight, the metallostar complex [Fe{Gd2L(H2O)4}3]4− (see picture; L is a bipyridine–poly(aminocarboxylate) derivative) displays exceptionally high proton relaxivity, which is explained in terms ...

Wiley-VCH Verlag GmbH2005

Destroying gadofullerene aggregates by salt addition in aqueous solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10

André Merbach, Lothar Helm, Eva Jakab Toth, Sabrina Laus

2005

The effect of pyridinecarboxylate chelating groups on the stability and electronic relaxation of gadolinium complexes

André Merbach, Lothar Helm, Alain Borel, Marinella Mazzanti

The ligand N,N'-bis[6-carboxy-2-pyridylmethyl]ethylenediamine-N,N'-diacetic acid (H4bpeda) was synthesized using an improved procedure which requires a reduced no. of steps and leads to a higher yield with respect to the published procedure. It was obtaine ...

2005

Inorganic and Bioinorganic Solvent Exchange Mechanisms

André Merbach, Lothar Helm

2005

Superparamagnetic gadonanotubes are high-performance MRI contrast agents

André Merbach, Lothar Helm, Eva Jakab Toth, Sabrina Laus

Royal Society of Chemistry2005

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