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André Merbach

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Related publications (40)

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Unexpected Aggregation of Neutral, Xylene-Cored Dinuclear GdIII Chelates in Aqueous Solution

André Merbach, Lothar Helm

2006

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

André Merbach, Lothar Helm, Alain Borel, Loïck Moriggi

A multiple-frequency (9.4-325 GHz) and variable-temperature (276-320 K) electron paramagnetic resonance (EPR) study on low molecular weight gadolinium(III) complexes for potential use as magnetic resonance imaging (MRI) contrast agents has been performed. ...

2007

High Relaxivity Confined to a Small Molecular Space: A Metallostar-Based, Potential MRI Contrast Agent

André Merbach, Alain Borel, Joao Bruno Livramento Fig.

Good things come in small packages: For its moderate molecular weight, the metallostar complex [Fe{Gd2L(H2O)4}3]4− (see picture; L is a bipyridine–poly(aminocarboxylate) derivative) displays exceptionally high proton relaxivity, which is explained in terms ...

Wiley-VCH Verlag GmbH2005

Relevance of the Ligand Exchange Rate and Mechanism of fac-[(CO)3M(H2O)3]+ (M = Mn, Tc, Re) Complexes for New Radiopharmaceuticals

André Merbach, Lothar Helm, Pascal Grundler

2006

Separation and Characterization of the Two Diastereomers for [Gd(DTPA-bz-NH2)(H2O)]2-, a Common Synthon in Macromolecular MRI Contrast Agents: Their Water Exchange and Isomerization Kinetics

André Merbach

2005

A High-Frequency EPR Study of Frozen Solutions of Gd(III) Complexes: Straightforward Determination of the Zero-Field Splitting Parameters and Simulation of the NMRD Profiles

André Merbach, Lothar Helm, Alain Borel

Gd(III) (S = 7/2) polyaminocarboxylates, used as contrast agents for Magnetic Resonance Imaging (MRI), were studied in frozen solutions by High-Frequency-High-Field Electron Paramagnetic Resonance (HF-EPR). EPR spectra recorded at 240 GHz and temperatures ...

2006

Gadolinium(III) complexes of mono-and diethyl esters of monophosphinic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies

André Merbach, Lothar Helm

2007

Fine-tuning water exchange on GdIII poly(amino carboxylates) by modulation of steric crowding

André Merbach

2005

Isomerization mechanisms of a labile Co(II) octahedral complex

André Merbach, Lothar Helm, Fabrice Riblet

The labile cobalt (II) complex [Co(TUF)2(Pic)2] with 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (TUF) bidentate and 4-methylpyridine (Pic) monodentate ligands was studied by variable temp. (VT) 19F NMR from 184 to 312 K. In contrast to the solid state, ...

2006

Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers

André Merbach, Lothar Helm, Loïck Moriggi

Springer2007

Rigid M(II)L2Gd(III)2 (M=Fe, Ru) Complexes of a Terpyridine-Based Heteroditopic Chelate: A Class of Candidates for MRI Contrast Agents

André Merbach, Lothar Helm

2005

Water-Exchange Study Revealed Unexpected Substitution Behavior of [(CO)2(NO)Re(H2O)3]2+ in Aqueous Media

André Merbach, Lothar Helm, Pascal Grundler, Marie-Line Lehaire

The pH-dependent water-exchange rates of [(CO)2(NO)Re(H2Ocis)2(H2Otrans)]2+ (1) in aq. media were investigated by means of 17O NMR spectroscopy at 298 K. Because of the low pKa value found for 1 (pKa = 1.4 ± 0.3), the water-exchange rate const. kobsH2Otran ...

2006

Lanthanide(III) chelates of DTPA bis(amide) glycoconjugates: potential imaging agents targeted at the asyaloglycoprotein receptor

André Merbach

2005

Synthesis and complexation properties of DTPA-N,N"-bis[bis(n-butyl)]-N'-methyl-tris(amide). Kinetic stability and water exchange of its Gd3+ complex

André Merbach

2005

Water and proton Exchange Processes on Metal Ions

André Merbach, Lothar Helm, Gaëlle Nicolle

2005

Dinuclear, Bishydrated GdIII Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton Relaxivities

André Merbach, Lothar Helm

2005

André Merbach

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Unexpected Aggregation of Neutral, Xylene-Cored Dinuclear GdIII Chelates in Aqueous Solution

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

High Relaxivity Confined to a Small Molecular Space: A Metallostar-Based, Potential MRI Contrast Agent

Relevance of the Ligand Exchange Rate and Mechanism of fac-[(CO)3M(H2O)3]+ (M = Mn, Tc, Re) Complexes for New Radiopharmaceuticals

Separation and Characterization of the Two Diastereomers for [Gd(DTPA-bz-NH2)(H2O)]2-, a Common Synthon in Macromolecular MRI Contrast Agents: Their Water Exchange and Isomerization Kinetics

A High-Frequency EPR Study of Frozen Solutions of Gd(III) Complexes: Straightforward Determination of the Zero-Field Splitting Parameters and Simulation of the NMRD Profiles

Gadolinium(III) complexes of mono-and diethyl esters of monophosphinic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies

Fine-tuning water exchange on GdIII poly(amino carboxylates) by modulation of steric crowding

Isomerization mechanisms of a labile Co(II) octahedral complex

Physicochemical and MRI characterization of Gd3+-loaded polyamidoamine and hyperbranched dendrimers

Rigid M(II)L2Gd(III)2 (M=Fe, Ru) Complexes of a Terpyridine-Based Heteroditopic Chelate: A Class of Candidates for MRI Contrast Agents

Water-Exchange Study Revealed Unexpected Substitution Behavior of [(CO)2(NO)Re(H2O)3]2+ in Aqueous Media

Inorganic and Bioinorganic Solvent Exchange Mechanisms

Understanding Paramagnetic Relaxation Phenomena for Water-Soluble Gadofullerenes

Destroying gadofullerene aggregates by salt addition in aqueous solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10

Superparamagnetic gadonanotubes are high-performance MRI contrast agents

Lanthanide(III) chelates of DTPA bis(amide) glycoconjugates: potential imaging agents targeted at the asyaloglycoprotein receptor

Synthesis and complexation properties of DTPA-N,N"-bis[bis(n-butyl)]-N'-methyl-tris(amide). Kinetic stability and water exchange of its Gd3+ complex

Water and proton Exchange Processes on Metal Ions

Dinuclear, Bishydrated GdIII Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton Relaxivities