Publications de Arnaud Bertsch

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This paper presents advances in micro and nanofabrication techniques beyond conventional lithographic masks with examples of inkj et printing, nanostencil lithography, molecular-level doping methods, and thermal scanning probe lithography. These methods en ...

Continuous fluidic sampling systems allow collection of brain biomarkers in vivo. Here, we propose a new sequential and intermittent sampling paradigm using droplets, called Droplet on Demand (DoD). It is implemented in a microfabricated neural probe and a ...

Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...

We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each ‘sub-sensor’ po ...

As microfiber-based additive manufacturing (AM) technologies, melt electrowriting (MEW) and solution electrowriting (SEW) have demonstrated efficacy with more biomedically relevant materials. By processing SU-8 resin using MEW and SEW techniques, a materia ...

Electrostatic interactions dominate the diffusion of proteins in a nanochannel, which was measured and modeled for pH values above and below the isoelectric points of three lectin proteins. Maximal diffusion coefficients were obtained when the proteins wer ...

Ligament balance is an important and subjective task performed during total knee arthroplasty (TKA) procedure. For this reason, it is desirable to develop instruments to quantitatively assess the soft-tissue balance since excessive imbalance can accelerate ...

Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However; there is a pressing need to find a simple, reliable, irreversible bonding method between these tw ...

Transport of proteins in liquid-filled nanometer-sized apertures with charged surfaces based on both diffusion and convective flow is investigated with the use of fluorescence correlation spectroscopy. The measured fluctuations of fluorescence allow the ev ...

The invention relates to formulations for water-insoluble active pharmaceutical ingredients. more particularly, the invention relates to a mucoadhesive patch consisting of a first layer consisting of a mucoadhesive film and a second layer consisting of a self-emulsifying drug delivery system (sedds) lipid microstructure for delivery of a poor water-soluble active pharmaceutical ingredient or a water insoluble active pharmaceutical ingredient.

This paper reports on the technology development and characterization of polyimide-based, microfluidic channels with integrated nanoporous membranes. A layer transfer and lamination technique is used to fabricate flexible microchannels from spin-on polyimi ...

The goal of this experiment was to determine the electrical properties of the tissue reaction to implanted microelectrode arrays. We describe a new method of analyzing electrical impedance spectroscopy data to determine the complex impedance of the tissue ...

A novel fabrication method based on the local sputtering of photoresist sidewalls during ion beam etching is presented. This method allows for the manufacture of three-dimensional multimaterial nanostructures at the wafer scale in only four process steps. ...

This paper is associated with a video winner of a 2019 American Physical Society's Division of Fluid Dynamics (DFD) Gallery of Fluid Motion Award for work presented at the DFD Gallery of Fluid Motion. The original video is available online at the Gallery o ...

Healthy Aims is a 23- million, four-year project, funded under the EU's information society technology sixth framework program to develop intelligent medical implants and diagnostic systems (www.healthyaims.org). The project has 25 partners from 10 countri ...

We present a microfluidic platform for the synthesis of monodisperse chitosan based nanoparticles via self-assembly at physiological pH. The resultant nanoparticles are shown to encapsulate hydrophobic anticancer drugs while providing a sustainable release profile with high tunability.

In this work we demonstrate a new process for precisely encapsulating nanoliters of aqueous solution in a microcapsule. Microcapsules were fabricated by twophoton polymerization and subsequently filled and sealed by inkjet printing. Our new approach overco ...

The following paper describes a sacrificial layer method for the manufacturing of microfluidic devices in polyimide and SU-8. The technique uses heat-depolymerizable polycarbonates embedded in polyimide or SU-8 for the generation of microchannels and seale ...

Arnaud Bertsch

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Beyond the Mask: Advancing Fabrication and Immersive Learning

On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid

Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation

A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

Electrowriting of SU-8 Microfibers

pH Controlled Diffusion of Proteins with Different pI Values across a Nanochannel on a Chip

Smart instrumentation for determination of ligament stiffness and ligament balance in total knee arthroplasty

SU8-silver photosensitive nanocomposite

A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

Direct measurement of diffusing proteins in nanochannels using fluorescence correlation spectroscopy

Sublingual patch

Flexible microchannels with integrated nanoporous membranes for filtration and separation of molecules and particles

in vivo Electrical Impedance Spectroscopy of Tissue Reaction to Microelectrode Arrays

Ion beam etching redeposition for 3D multimaterial nanostructure manufacturing

Demonstration of cortical recording and reduced inflammatory response using flexible polymer neural probes

Swinging jets

Healthy Aims: Developing new medical implants and diagnostic equipment

Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents

LIQUID-IN-A-MEMS: ENCAPSULATION OF LIQUID IN A MICROCAPSULE BY INKJET PRINTING

Polyimide and SU-8 microfluidic devices manufactured by heat- depolymerizable sacrificial material technique