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Horst Pick

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Publications associées (41)

Immuno-affinity Amperometric Detection of Bacterial Infections

Hubert Girault, Horst Pick, Michel Prudent, Andreas Stephan Lesch, Yingdi Zhu, Milica Jovic

A combination of an immuno-affinity enrichment strategy and sensitive amperometric read-out was implemented in a point-of-care platform intended for bacterial infection analysis. Bacterial cells, selectively captured and enriched from complex matrices thro ...

Wiley-VCH Verlag GmbH2018

Weiche elektrochemische Sonden zum Abbilden der Verteilung von Biomarkern und injizierten Nanomaterialien in tierischem und menschlichem Gewebe

Hubert Girault, Horst Pick, Yu Lu, Andreas Stephan Lesch, Tzu-En Lin

Die Untersuchung von Biomarkern und injizierten theranostischen Nanomaterialien in Geweben und Organen spielt eine zentrale Rolle bei zahlreichen medizinischen Verfahren von der Krebsdiagnose bis hin zur Arzneimittelverabreichung. Zu diesem Zweck kann die ...

Wiley-Blackwell2017

Soft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues

Hubert Girault, Horst Pick, Yu Lu, Andreas Stephan Lesch, Tzu-En Lin

Monitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerf ...

Wiley-Blackwell2017

Sensitive and fast identification of bacteria in blood samples by immunoaffinity mass spectrometry for quick BSI diagnosis

Hubert Girault, Horst Pick, Michel Prudent, Niels Erik Lion, Liang Qiao, Natalia Gasilova, Alexandra Bondarenko, Yingdi Zhu

Bloodstream infections rank among the most serious causes of morbidity and mortality in hospitalized patients, partly due to the long period (up to one week) required for clinical diagnosis. In this work, we have developed a sensitive method to quickly and ...

Royal Soc Chemistry2016

Untersuchung der Tyrosinase-Expression in nicht-metastatischen und metastatischen Melanomgeweben durch elektrochemische Rastersondenmikroskopie

Hubert Girault, Horst Pick, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Tzu-En Lin

Trotz des enormen Fortschritts, der bei der Diagnose von Melanomen erzielt wurde, bleibt die zuverlässige Erkennung der verschiedenen Malignomstadien eine Herausforderung. Derzeitige Strategien setzen auf die optische Erfassung der Konzentration und räumli ...

Wiley-Blackwell2016

Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy

Hubert Girault, Horst Pick, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Tzu-En Lin

Although tremendous progress has been made in the diagnosis of melanoma, the identification of different stages of malignancy in a reliable way remains challenging. Current strategies rely on optical monitoring of the concentration and spatial distribution ...

Wiley-Blackwell2016

Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells

Hubert Girault, Horst Pick, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Petar Stupar, Tzu-En Lin

Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imaging of dynamic topographical and metabolic changes in alive adherent mammalian cells. However, extracting intracellular information by SECM is challenging, since it ...

American Chemical Society2016

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Vogel, Horst Pick, Olivia Baud, Luc Veya, Shuguang Yuan

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

Electrostatic Spray Ionization Mass Spectrometry Imaging

Hubert Girault, Horst Vogel, Horst Pick, Liang Qiao, Elena Tobolkina, Andreas Stephan Lesch, Alexandra Bondarenko, Xiaoqin Zhong

Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new ...

Amer Chemical Soc2014

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

Horst Vogel, Samuel Terrettaz, Horst Pick, Olivia Baud, Cathrin Brisken

The human estrogen receptor alpha (ER!) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these pro ...

Elsevier2013

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs

Horst Vogel, Horst Pick

2012

Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent

Horst Vogel, Horst Pick

The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the ce ...

2011

Recombinant expression and functional characterization of the mouse olfactory receptor mOR256-17 in mammalian cells

Horst Vogel, Horst Pick, Thamani Dahoun, Luigino Grasso

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system in recognizing and discriminating a nearly unlimited number of structurally diverse odorous molecules. The mol ...

2011

The Mouse Eugenol Odorant Receptor: Structural and Functional Plasticity of a Broadly Tuned Odorant Binding Pocket

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the ability of the mammalian olfactory system to detect and discriminate a vast variety of odors with a limited set of receptors. How a particular OR bind ...

American Chemical Society2011

Bioanalytical procedure to detect membrane receptor activation

Horst Vogel, Horst Pick

The invention concerns a method for screening compound interaction with transmembrane receptors involved in cellular signal transduction, preferably with G protein coupled receptors, by adding the compound to be analyzed into a medium comprising native inv ...

2010

Dual activities of odorants on olfactory and nuclear hormone receptors

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter, Ralf Schmauder

We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neurons and the human nuclear estrogen rec ...

American Society for Biochemistry and Molecular Biology2009

Distribution Plasticity of the Human Estrogen Receptor α in Live Cells: Distinct Imaging of Consecutively Expressed Receptors

Horst Vogel, Horst Pick, Hanna Jankevics

Elsevier2007

Visualizing odorant receptor trafficking in living cells down to the single-molecule level

Horst Vogel, Horst Pick, Valérie Jacquier, Jean-Manuel Segura

Despite the importance of trafficking for regulating G protein-coupled receptor signaling, for many members of the seven transmembrane helix protein family, such as odorant receptors, little is known about this process in live cells. Here, the complete lif ...

National Academy of Sciences2006

Investigating cellular signaling reactions in single attoliter vesicles

Rudolf Hovius, Horst Vogel, Horst Pick, Erwin Ilegems

Understanding cellular signaling mediated by cell surface receptors is key to modern biomedical research and drug development. The discovery of a growing no. of potential mol. targets and therapeutic compds. requires downscaling and accelerated functional ...

2005

Diffusion-Time Distribution Analysis Reveals Characteristic Ligand-Dependent Interaction Patterns of Nuclear Receptors in Living Cells

Horst Vogel, Horst Pick, Hanna Jankevics, Paulina Izewska

Nuclear receptors initiate transcription, interact with regulatory proteins, and are influenced by hormones, drugs, and pollutants. Herein, we discover ligand-specific mobility patterns of human estrogen receptor-a (ER) in living cells using diffusion-time ...

2005

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