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Horst Pick

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Publications associées (41)

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The G protein coupled receptor CXCR4 designed by the QTY code becomes more hydrophilic and retains cell signaling activity

Horst Arthur Vogel, Horst Pick

G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studi ...

NATURE RESEARCH2020

Skin cell analysis

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Tzu-En Lin, Yingdi Zhu

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...

2020

Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

Bart Deplancke, Beat Fierz, Horst Pick, David Michael Suter, Cédric Deluz, Antonio Carlos Alves Meireles Filho, Nora Guidotti, Andreas Linus Bachmann, Carolin Christine Lechner, Aurore Marie-France Delachat

2018

Electrostatic Spray Ionization Mass Spectrometry Imaging

Hubert Girault, Horst Arthur Vogel, Andreas Stephan Lesch, Liang Qiao, Horst Pick, Alexandra Bondarenko, Elena Tobolkina, Xiaoqin Zhong

Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new ...

Amer Chemical Soc2014

Bioanalytical procedure to detect membrane receptor activation

Horst Arthur Vogel, Horst Pick

The invention concerns a method for screening compound interaction with transmembrane receptors involved in cellular signal transduction, preferably with G protein coupled receptors, by adding the compound to be analyzed into a medium comprising native inv ...

2010

Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy

Hubert Girault, Fernando Cortes Salazar, Andreas Stephan Lesch, Horst Pick, Alexandra Bondarenko, Tzu-En Lin

Although tremendous progress has been made in the diagnosis of melanoma, the identification of different stages of malignancy in a reliable way remains challenging. Current strategies rely on optical monitoring of the concentration and spatial distribution ...

Wiley-Blackwell2016

Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Natalia Gasilova, Tzu-En Lin, Milica Jovic, Yingdi Zhu

Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detec ...

2021

Soft-probe-scanning electrochemical microscopy reveals electrochemical surface reactivity of E. coli biofilms

Hubert Girault, Emad Oveisi, Andreas Stephan Lesch, Horst Pick, Sorour Darvishi

Investigating and understanding dynamic biofilm growth mechanisms is challenging, often because state-of-the-art optical characterization tools provide limited information. Micrometric electrochemical imaging of Escherichia coli biofilms using Soft-Probe-S ...

Elsevier2021

Maldi device and methods of preparation and use thereof

Hubert Girault, Liang Qiao, Horst Pick, Milica Jovic, Yingdi Zhu

A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised pho ...

2018

Algal cellulose, production and potential use in plastics: Challenges and opportunities

Tobias Borgmeyer, Christian Ludwig, Horst Pick, Eya Nicodeme, Adrian Pulgarin, Enio Daniel Zanchetta

The development of new biodegradable plastic materials from renewable sources is a major challenge for plastic industries to provide sustainable alternatives to petroleum plastic. Bio-based plastics are generally obtained from photosynthetic biomass such a ...

2021

Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles

Horst Arthur Vogel, Horst Pick, Shuguang Yuan, Luc Veya, Olivia Baud

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly unde ...

Nature Publishing Group2015

Abiotic stress approaches for enhancing cellulose and chitin production in Chlorella vulgaris

Christian Ludwig, Horst Pick, Eya Nicodeme, Ayush Agarwal, Enio Daniel Zanchetta

Several lines of evidence point to the presence of both, cellulose and chitin as structural constituents of the Chlorella vulgaris cell wall. These biopolymers are favourable building blocks for many sustainable industrial applications for instance as bioc ...

Elsevier BV2025

Print-Light-Synthesis of ruthenium oxide thin film electrodes for electrochemical sensing applications

Andreas Stephan Lesch, Horst Pick

Print-Light-Synthesis (PLS) combines the inkjet printing of a ruthenium precursor ink with the simultaneous photo-induced generation of ruthenium oxide films. During PLS, inkjet-printing generates on conductive as well as insulating substrates micrometer-t ...

Elsevier BV2025

Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent

Horst Arthur Vogel, Horst Pick

The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the ce ...

2011

Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry

Hubert Girault, Liang Qiao, Horst Pick, Natalia Gasilova, Milica Jovic, Yingdi Zhu

Titanium dioxide-modified target plates were developed to enhance intact bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The plates were designed to photocatalytically destroy the bacterial envelope struct ...

2018

Distribution Plasticity of the Human Estrogen Receptor α in Live Cells: Distinct Imaging of Consecutively Expressed Receptors

Horst Arthur Vogel, Horst Pick, Hanna Jankevics

Elsevier2007

Untersuchung der Tyrosinase-Expression in nicht-metastatischen und metastatischen Melanomgeweben durch elektrochemische Rastersondenmikroskopie

Hubert Girault, Horst Pick, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Tzu-En Lin

Trotz des enormen Fortschritts, der bei der Diagnose von Melanomen erzielt wurde, bleibt die zuverlässige Erkennung der verschiedenen Malignomstadien eine Herausforderung. Derzeitige Strategien setzen auf die optische Erfassung der Konzentration und räumli ...

Wiley-Blackwell2016

RB714, RB715, RB716, RB717 and RB718 antibodies recognize the histone HMtA protein from Methanobrevibacter smithii by ELISA

Horst Pick, Duncan-Bruce Sutherland

The recombinant antibodies RB714, RB715, RB716, RB717 and RB718 detect by ELISA the M. smithi histone HMtA protein fused to a GST. ...

2022

Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Fernando Cortes Salazar, Alexandra Bondarenko, Tzu-En Lin, Petar Stupar

Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imaging of dynamic topographical and metabolic changes in alive adherent mammalian cells. However, extracting intracellular information by SECM is challenging, since it ...

American Chemical Society2016

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs

Horst Arthur Vogel, Horst Pick

2012