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Philippe Renaud

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Publications associées (301)

Label-free determination of protein–surface interaction kinetics by ionic conductance inside a nanochannel

Philippe Renaud, Nicolas Durand

2009

On-chip thermopneumatic actuation system for coagulation time measurement

François Bianchi, Philippe Renaud, Lynda Metref, Pierre Lemaire

This work reports the demonstration of a thermopneumatic microfluidic actuator used to determine blood coagulation time. In this new system, the detection principle is the obstruction of a microfluidic channel by clotted blood. The sample actuation is done ...

Elsevier2009

Direct Observation of Transitions between Surface-Dominated and Bulk Diffusion Regimes in Nanochannels

Philippe Renaud, Arnaud Bertsch, Theo Lasser, Nicolas Durand, Claudio Dellagiacoma, Raphaël Goetschmann

The diffusion of charged proteins in liquid-filled nanometer-sized apertures with charged surfaces has been investigated with fluorescence correlation spectroscopy (FCS). Based on a two-dimensional (2D) multicomponent diffusion model, key parameters such a ...

2009

Wireless contact lens sensor for intra ocular pressure monitoring: assessment on enucleated pig eyes

Matteo Leonardi, André Mermoud, Philippe Renaud, Arnaud Bertsch

Purpose: Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). Methods: The wireless CLS is a disposable silicone soft co ...

2009

Nanofluidic platform for label-free proteins detection

Philippe Renaud, Nicolas Durand, Fabien Patrick Wildhaber

2009

Sequential build-up of hydrogel environments around single cells

Philippe Renaud, Joël Theytaz, Thomas Michael Braschler, Anja Kunze, Grazia Loche, Ana Valero, Ludovica Colella

Controlling alginate gel formation by diffusion of Ca ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It gives the possibility of exposing cells under biocompatible condi ...

2009

Label-free determination of protein-surface interaction kinetics by ionic conductance inside a nanochannel

Philippe Renaud, Nicolas Durand

We have developed a label-free conductometric platform for the rapid measurement of kinetics parameters for the adsorption and desorption of proteins on surfaces. Adsorbed Bovine Serum Albumin (BSA) has been detected electrically with response times in the ...

2009

Micromachined chip-scale plasma light source

Philippe Renaud, Herbert Shea

We report on the microfabrication and testing of a chip- scale plasma light source. The device consists of a stack of three anodically bonded Pyrex wafers, which hermetically enclose a gas-filled cavity containing interdigitated Aluminum electrodes. When t ...

Elsevier2009

Detecting proteins complex formation using steady-state diffusion in a nanochannel

Philippe Renaud, Nicolas Durand

In this work, we present theoretical and experimental studies of nanofluidic channels as a potential biosensor for measuring rapid protein complex formation. Using the specific properties offered by nanofluidics, such as the decrease of effective diffusion ...

2009

Development and studies of a novel microfabricated radiation hard scintillation particle detector with high spatial resolution

Philippe Renaud, Alessandro Mapelli, Sébastien Jiguet

A novel scintillation detector is being developed with standard microfabrication techniques. It consists of a dense array of scintillating waveguides obtained by filling microfluidic channels with an organic liquid scintillator. Such a microfluidic device ...

2009

in vivo Electrical Impedance Spectroscopy of Tissue Reaction to Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun

The goal of this experiment was to determine the electrical properties of the tissue reaction to implanted microelectrode arrays. We describe a new method of analyzing electrical impedance spectroscopy data to determine the complex impedance of the tissue ...

2009

Wide channel dielectrophoresis-based particle exchanger with electrophoretic diffusion compensation

Philippe Renaud, Raphaël Tornay, Thomas Michael Braschler

We present here a microfluidic device for the chemical modification of particles. In order to alleviate diffusive mixing issues beads are pushed from a starting buffer to a reagent over a wide channel by an array of shifted electrodes. We also show that th ...

2009

Biochip with E-Coli bacteria for detection of arsenic in drinking water

Philippe Renaud, Harald Van Lintel, Joël Theytaz, Jan Roelof van der Meer, Thomas Michael Braschler

Arsenic and other pollutants are often present in trace amounts in drinking water in a number of countries. In aqueous solutions the sensitivity of arsenic-responsive bacterial bioreporters is far better than the performance of chemical field test kits. Ho ...

2009

Substrate arrays of iridium oxide microelectrodes for in-vitro neuronal interfacing

Marc Olivier Heuschkel, Shady Didier Gawad, Philippe Renaud, Henry Markram, Michele Giugliano

The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...

2009

Experimental study of electrical breakdown in MEMS devices with micrometer scale gaps

Philippe Renaud, Herbert Shea

We present an experimental study of the DC breakdown voltage of MEMS interdigitated aluminum electrodes with gaps ranging from 10 to 500 μm. Unlike most research on MEMS electrodes that was done at atmospheric pressure, our work has focused on the effect o ...

2008

Low-power hermetically sealed on-chip plasma light source micromachined in glass

Philippe Renaud, Herbert Shea

We report on the fabrication and testing of a chip-scale plasma light source. The device consists of a stack of three anodically bonded Pyrex wafers, which hermetically enclose a gas-filled cavity in which electrodes are used to ignite a low power (≪500 mW ...

2008

Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles

Heinrich Hofmann, Philippe Renaud, Nicolas Demierre, Raphaël Tornay, Jeffrey Alan Hubbell, Thomas Michael Braschler, Benedikt Steitz, Andrija Finka

We present a microfluidic device where micro- and nanoparticles can be continuously functionalized in flow. This device relies on an element called particle exchanger, which allows for particles to be taken from one medium and exposed to some reagent while ...

2008

Modelling and microfabrication of a polyimide-based 3D tissue coupled electrodes for electrical stimulation in the chick retina

Philippe Renaud, Sri Harsha Kasi Raj

We present a new flexible microfabricated polyimide-based platinum array of 3D “tissue coupled electrodes” (TCEs) applied for local stimulation of the chick retinal photoreceptor layer and simultaneous patch clamp recording from a single retinal ganglion c ...

2008

Low-power hermetically sealed on-chip plasma light source micromachined in glass

Philippe Renaud, Herbert Shea

2008

Transport phenomena in nanofluidics

Philippe Renaud, Reto Bruno Schoch

Transport of fluid in and around nanometer-sized objects with at least one characteristic dimension below 100 nm renders possible phenomena that are not accessible at bigger length scales. This research field is termed nanofluidics and received its name on ...

2008

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