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Nikolaos Stergiopoulos

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Publications associées (238)

An assessment of ductus venosus tapering and wave transmission from the fetal heart

Nikolaos Stergiopoulos

Pressure and flow pulsations in the fetal heart propagate through the precordial vein and the ductus venosus (DV) but are normally not transmitted into the umbilical vein (UV). Pulsations in the umbilical vein do occur, however, in early pregnancy and in p ...

2009

Non-invasively adjustable drainage device

Nikolaos Stergiopoulos

The device comprises at least an inlet tube (1 ) for the passage of fluid to be drained, said tube (1 ) being connected to a chamber (2) wherein said chamber (2) comprises rotating means (4,5) for adjusting the flow rate in said tube. ...

2009

Validation Of A Person Specific 1D Model Of The Systemic Arterial Tree

Nikolaos Stergiopoulos, Philippe Reymond, Yvette Bohraus

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension

Nikolaos Stergiopoulos, Nico Westerhof

The product of resistance, R, and compliance, C (RC time), of the entire pulmonary circulation is constant. It is unknown if this constancy holds for individual lungs. We determined R and C in individual lungs in chronic thromboembolic pulmonary hypertensi ...

2009

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Jeffrey Alan Hubbell, Simone Cavadini, Yun Suk Jo, Jay Gantz, Tyler Nerton Thacher, Davide Demurtas

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Validation of a one-dimensional model of the systemic arterial tree

Nikolaos Stergiopoulos, Fabrice Merenda, Philippe Reymond

A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughou ...

2009

Regulation of arginase pathway in response to wall shear stress

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Fabienne Riche, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including ather ...

2009

The Effect Of Collagen Fiber Directional Distribution On The Mechanical Response Of The Vascular Wall

Nikolaos Stergiopoulos, Rana Saitta-Rezakhaniha

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives

Nikolaos Stergiopoulos, Luca Augsburger, Mohamed Farhat, Philippe Reymond, Edouard Fonck

With intracranial aneurysms disease bringing a weakened arterial wall segment to initiate, grow and potentially rupture an aneurysm, current understanding of vessel wall biology perceives the disease to follow the path of a dynamic evolution and increasing ...

2009

Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms

Nikolaos Stergiopoulos, Philippe Reymond

Haemodynamics is believed to play an important role in the initiation, growth and rupture of intracranial aneurysms. In this context, computational haemodynamics has been extensively used in an effort to establish correlations between flow variables and cl ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall and on smooth muscle function

Nikolaos Stergiopoulos, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress act in concert and yet are capable of independently mediating arterial smooth muscle function, modulating the production of superoxide and stimulating arterial remodeling. ...

Oxford University Press2009

Effect of Ageing on Elastin Functionality in Human Cerebral Arteries

Nikolaos Stergiopoulos, Jean Fasel, Michaël Unser, Daniel Sage, Edouard Fonck

ASME2008

Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher

With advancing age arteries stiffen, reducing arterial compliance and leading to the development of systolic hypertension and to a substantial increase in pulse pressure. An augmented pulse pressure can be a predictor of the development of hypertension, wh ...

Oxford University Press2008

Effect of an abdominal aortic aneurysm on wave reflection in the aorta

Nikolaos Stergiopoulos, Patrick Segers

Despite extensive attention to abdominal aortic aneurysm (AAA) in the biomedical engineering community, its effect on aortic hemodynamics and arterial wave reflection has not been addressed before. We used experimental and numerical methods, relying on a r ...

2008

Three- and four-element Windkessel models: assessment of their fitting performance in a large cohort of healthy middle-aged individuals

Nikolaos Stergiopoulos, Nico Westerhof, Patrick Segers

Lumped-parameter models are used to estimate the global arterial properties by fitting the model to measured (aortic) pressure and flow. Different model configurations coexist, and it is still an open question as to which model optimally reflects the arter ...

2008

Implantable drug delivery device

Nikolaos Stergiopoulos, Michel Bachmann

An Implantable delivery device comprising at least a body (1), an inlet (2 17 46) and an outlet (3 18 47) and actuating means, wherein the actuating means comprise at least an actuator displacing a piston (6 21 32) in a rotating cylinder (4 19 31) forming ...

2008

Transcriptional and post-transcriptional regulation of endothelin-1 gene by shear stress

Nikolaos Stergiopoulos, Paolo Silacci, Rafaela Fernandes Da Silva

Objective Plaque-prone areas are exposed to a particular hemodynamic environment characterized by a low mean shear stress value and a cyclic reversal flow. This mechanical environment, also termed oscillatory shear stress (OSS), induces the expression of s ...

2008

Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest

Nikolaos Stergiopoulos, Nico Westerhof

Central aortic pressure gives better insight into ventriculo-arterial coupling and better prognosis of cardiovascular complications than peripheral pressures. Therefore transfer functions (TF), reconstructing aortic pressure from peripheral pressures, are ...

2008

A structural model of the venous wall considering elastin anisotropy

Nikolaos Stergiopoulos

The three-dimensional biomechanical behavior of the vascular wall is best described by means of strain energy functions. Significant effort has been devoted lately in the development of structure-based models of the vascular wall, which account for the ind ...

2008

Endothelialization Of Decellularized Porcine Arteries

Nikolaos Stergiopoulos, Paolo Silacci, Sylvain Roy

2008

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