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Nikolaos Stergiopoulos

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Publications associées (238)

Fluid Structure Interaction Simulations of Physiological Blood Flow in the Aorta

Nikolaos Stergiopoulos, Alfio Quarteroni, Simone Deparis, Philippe Reymond, Paolo Crosetto, Dimitrios Kontaxakis

The numerical tools to simulate blood flow in the cardiovascular system are constantly developing due to the great clinical interest and to scientific advances in mathematical models and computational power. The present work aims to address and validate ne ...

Elsevier2011

Validation of the arteriograph working principle: questions still remain - reply 2

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

2011

A constituent-based model of age-related changes in conduit arteries

Alexander Rachev, Nikolaos Stergiopoulos, Alkiviadis Tsamis

Tsamis A, Rachev A, Stergiopulos N. A constituent-based model of age-related changes in conduit arteries. Am J Physiol Heart Circ Physiol 301: H1286-H1301, 2011. First published July 1, 2011; doi: 10.1152/ajpheart.00570.2010.-In the present report, a const ...

2011

A structural constitutive model considering angular dispersion and waviness of collagen fibres of rabbit facial veins

Nikolaos Stergiopoulos, Aristotelis Agianniotis

Background: Structural constitutive models of vascular wall integrate information on composition and structural arrangements of tissue. In blood vessels, collagen fibres are arranged in coiled and wavy bundles and the individual collagen fibres have a devi ...

BioMed Central2011

Experimental characterization of the distribution of collagen fiber recruitment

Nikolaos Stergiopoulos, Christophe Boss, Sylvain Roy

The passive biomechanical behavior of blood vessels is generally modeled by a parallel arrangement of elastin and collagen, with collagen recruitment depending on vessel strain. We experimentally determined the collagen recruitment distribution using confo ...

2010

Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt

Nikolaos Stergiopoulos

Venous anastomotic intimal hyperplasia (IH) observed in the arteriovenous shunt (AVS) has been associated with disturbed hemodynamics. This study aims to correlate hemodynamics with wall histology and wall mechanics by examining the flow field in AVS with ...

2010

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva

Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibi ...

Oxford University Press2010

Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff

Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers, Bram Trachet

Recently a new method has been proposed as a tool to measure arterial pulse wave velocity (PWV), a measure of the stiffness of the large arteries and an emerging parameter used as indicator of clinical cardiovascular risk. The method is based on measuremen ...

Springer Verlag2010

Biomechanical, morphological and zero-stress state characterization of jugular vein remodeling in arteriovenous fistulas for hemodialysis

Nikolaos Stergiopoulos

While the role of hemodynamic variables on the development of intimal hyperplasia in arteriovenous fistulas for hemodialysis has been examined, less is known about the intramural biomechanical factors. In this study, arteriovenous fistulas were created by ...

2010

Left ventricular hypertrophy induced by reduced aortic compliance

Nikolaos Stergiopoulos, Nico Westerhof

It was the aim of this study to investigate the long- term effects of reduced aortic compliance on cardiovascular hemodynamics and cardiac remodeling. ...

2009

Validation Of I D Model Of The Systemic Arterial Tree Including The Cerebral Circulation

Nikolaos Stergiopoulos, Fabrice Merenda, Philippe Reymond, Daniel Ruefenacht

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Effects Of Reduced Compliance On Endothelial Functionality With Regards To Inflammation

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

A Structure-Based Model Of Arterial Remodeling In Response To Sustained Hypertension

Alexander Rachev, Nikolaos Stergiopoulos, Alkiviadis Tsamis

2009

Arterial remodeling in response to increased blood flow using a constituent-based model

Nikolaos Stergiopoulos, Alkiviadis Tsamis

Previous theoretical models of arterial remodeling in response to changes in blood flow were based on the assumption that material properties of the arterial wall remain unchanged during the remodeling process. According to experimental findings, however, ...

2009

Effect of aging on elastin functionality in human cerebral arteries

Nikolaos Stergiopoulos, Jean Fasel, Michaël Unser, Daniel Sage, Edouard Fonck

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...

ASA2009

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Nikolaos Stergiopoulos, Paolo Silacci, Sylvain Roy, Tyler Nerton Thacher

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

2009

Role Of Elastin Degradation In Identification Of Vascular Strain Energy Functions

Nikolaos Stergiopoulos, Edouard Fonck

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

A structure-based model of arterial remodeling in response to sustained hypertension

Alexander Rachev, Nikolaos Stergiopoulos, Alkiviadis Tsamis

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model

Nikolaos Stergiopoulos, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of supero ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

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