Publications de Stephan Morgenthaler

Publications associées (53)

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture microdissection and cycling temperature capillary electrophoresis

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occu ...

BioMed Central2017

Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression

Stephan Morgenthaler

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC deaths can be reduced with prevention and early diagnosis. Circulating tumor DNA-based liquid biopsies, are emerging tools for cancer detection. However, ...

2024

Comparing connectomes across subjects and populations at different scales

Jean-Philippe Thiran, Stephan Morgenthaler, Alessandra Griffa, Elda Fischi Gomez, Patric Hagmann, Djalel Eddine Meskaldji

Brain connectivity can be represented by a network that enables the comparison of the different patterns of struc- tural and functional connectivity among individuals. In the literature, two levels ofstatistical analysis have been con- sidered in comparing ...

2013

Inference for binomial probability based on dependent Bernoulli random variables with applications to meta-analysis and group level studies

Stephan Morgenthaler

We study bias arising as a result of nonlinear transformations of random variables in random or mixed effects models and its effect on inference in group-level studies or in meta-analysis. The findings are illustrated on the example of overdispersed binomi ...

Wiley-Blackwell2016

The Gaia mission

Stephan Morgenthaler, Shuangqing Liao

Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the ...

Edp Sciences S A2016

Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Patric Hagmann, Stephan Morgenthaler, Djalel Eddine Meskaldji, David Paul Roger Romascano

Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase ...

Elsevier2015

The Choice of Polar Stationary Phases for Gas-Liquid Chromatography by Statistical Analysis of Retention Data

Stephan Morgenthaler

We have studied the retention indices of 127 volatile substances on a C-78-paraffin and on its seven nearly isochor and isomorphous polar derivatives over a temperature range of 90-210 A degrees C. The retention index of a substance on the C-78 paraffin ha ...

Springer Verlag2009

Gaia Data Release 1 Summary of the astrometric, photometric, and survey properties

Stephan Morgenthaler, Shuangqing Liao

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illu ...

EDP Sciences2016

Prediction of long-term memory scores in MCI based on resting-state fMRI

Dimitri Nestor Alice Van De Ville, Stephan Morgenthaler, Djalel Eddine Meskaldji, Maria Giulia Preti, Thomas William Arthur Bolton

Resting-state functional MRI (rs-fMRI) opens a window on large-scale organization of brain function. However, establishing relationships between resting-state brain activity and cognitive or clinical scores is still a difficult task, in particular in terms ...

Elsevier Sci Ltd2016

Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations

Stephan Morgenthaler, Paul Refinetti

Background ...

FRONTIERS MEDIA SA2020

Heterogeneity in multistage carcinogenesis and mixture modeling

Stephan Morgenthaler, Sandro Gsteiger

Carcinogenesis is commonly described as a multistage process, in which stem cells are transformed into cancer cells via a series of mutations. In this article, we consider extensions of the multistage carcinogenesis model by mixture modeling. This approach ...

BioMed Central2008

Advantages of Variance Stabilization

Stephan Morgenthaler, Robert Staudte

Variance stabilization is a simple device for normalizing a statistic. Even though its large sample properties are similar to those of studentizing, many simulation studies of confidence interval procedures show that variance stabilization works better for ...

Wiley-Blackwell2012

Adaptive Strategy for the Statistical Analysis of Connectomes

Jean-Philippe Thiran, Reto Meuli, Patric Hagmann, Stephan Morgenthaler, Leila Cammoun, Djalel Eddine Meskaldji, Leila Faiza Ben Hamida Cammoun

We study an adaptive statistical approach to analyze brain networks represented by brain connection matrices of interregional connectivity (connectomes). Our approach is at a middle level between a global analysis and single connections analysis by conside ...

Public Library of Science2011

Testing parallaxes with local Cepheids and RR Lyrae stars

Stephan Morgenthaler, Shuangqing Liao

Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the HIPPARCOS and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Ai ...

Edp Sciences S A2017

A comprehensive error rate for multiple testing

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Stephan Morgenthaler, Djalel Eddine Meskaldji

Over the last two decades, a large variety of type I error rates and control procedures have been proposed in the field of multiple hypotheses testing. This paper proposes a framework that includes many existing proposals by investigating procedures in whi ...

SPRINGER2020

Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars

Stephan Morgenthaler, Richard Irving Anderson

All rights reserved.Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of 0.18âÃ Â€ ³ in the optical, making it an ideal instrument to search for gravitatio ...

2024

Gaia Data Release 1 Open cluster astrometry: performance, limitations, and future prospects

Stephan Morgenthaler, Shuangqing Liao

Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 po ...

Edp Sciences S A2017

Robust binary regression

Stephan Morgenthaler

Robust procedures increase the reliability of the results of a data analysis. We studied such a robust procedure for binary regression models based on the criterion of least absolute deviation. The resulting estimating equation consists in a simple modific ...

Elsevier2011

Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling

Stephan Morgenthaler, Paul Refinetti

The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) and human milk oligosaccharides in controlling intestinal inflammation and the pathogenesis of obesity and type 1 diabetes (T1D) has been largely studied ...

MDPI2024

Conditionally least-informative distributions: The case of the location parameter

Stephan Morgenthaler

We extend a basic result of Huber's on least favorable distributions to the setting of conditional inference, using an approach based on the notion of log-Gâteaux differentiation and perturbed models. Whereas Huber considered intervals of fixed width for l ...

2005