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Jean-Jacques Meister

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Publications associées (42)

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Jean-Jacques Meister, Lysianne Follonier Castella, Boris Hinz, Lara Buscemi Estefanell

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

Intercellular calcium waves are associated with the propagation of vasomotion along arterial strips

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Vasomotion consists of cyclic arterial diameter variations induced by synchronous contractions and relaxations of smooth muscle cells. However, the arteries do not contract simultaneously on macroscopic distances, and a propagation of the contraction can b ...

2010

Force transmission in migrating cells

Jean-Jacques Meister, Alexander Verkhovskiy, Roger Sauser, Maxime Fred Maurice Fournier

During cell migration, forces generated by the actin cytoskeleton are transmitted through adhesion complexes to the substrate. To investigate the mechanism of force generation and transmission, we analyzed the relationship between actin network velocity an ...

Rockefeller University Press2010

Mechanisms of Propagation of Intercellular Calcium Waves in Arterial Smooth Muscle Cells

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger

In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of similar to 20 cells/s and a range of similar to 80 cells. We analyze these waves in a theoret ...

Elsevier2010

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Hicham Majd, Jean-Jacques Meister, Boris Hinz, Pierre Jean Arnould Wipff, Lara Buscemi Estefanell

Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

Myofibroblast communication is controlled by intercellular mechanical coupling

Jean-Jacques Meister, Lysianne Follonier Castella, Sébastien Schaub, Boris Hinz

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical couplin ...

Company of Biologists2008

Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow

Jean-Jacques Meister, Alexander Verkhovskiy, Sébastien Schaub

Dynamic actin network at the leading edge of the cell is linked to the extracellular matrix through focal adhesions (FAs), and at the same time it undergoes retrograde flow with different dynamics in two distinct zones: the lamellipodium (peripheral zone o ...

Public Library of Science2008

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Jean-Jacques Meister, Philippe Pittet, Boris Hinz, Kyumin Lee

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects

Jean-Jacques Meister, Dominique Seppey, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Karger2008

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Jean-Jacques Meister, Boris Hinz, Pierre Jean Arnould Wipff

The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts a ...

Rockefeller University Press2007

Ob-cadherin establishes mechano-resistant junctions between myofibroblasts

Andrzej Kulik, Jean-Jacques Meister, Philippe Pittet, Boris Hinz, Kyumin Lee

2007

Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells

Jean-Jacques Meister, Sophie Bohnet, Alexander Verkhovskiy, Sébastien Schaub

To understand the mechanism of cell migration, one needs to know how the parts of the motile machinery of the cell are assembled and how they move with respect to each other. Actin and myosin II are thought to be the major structural and force-generating c ...

American Society for Cell Biology2007

Analysis of actin filament network organization in lamellipodia by comparing experimental and simulated images

Jean-Jacques Meister, Alexander Verkhovskiy, Sébastien Schaub

Protrusion of lamellipodia during cell migration depends on the assembly of actin network. The assembly mechanism, based on dendritic filament branching, has been investigated in reconstituted in vitro systems, but little is known about the dynamical and s ...

Company of Biologists2007

Stretch-elicited calcium responses in the intact mouse thoracic aorta

Jean-Jacques Meister, Jean-Louis Bény

Stretch-elicited intracellular calcium (Ca(2+)) changes in individual smooth muscle cells in a ring of aorta were measured simultaneously with the force developed by the ring. A phasic increase in Ca(2+) was observed in 30% of the cells and a sus ...

Elsevier2006

Effects of arterial wall stress on vasomotion

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

Smooth muscle and endothelial cells in the arterial wall are exposed to mechanical stress. Indeed blood flow induces intraluminal pressure variations and shear stress. An increase in pressure may induce a vessel contraction, a phenomenon known as the myoge ...

Elsevier2006

Emergent properties of electrically coupled smooth muscle cells

Jean-Jacques Meister, Michèle Koenigsberger, Roger Sauser

Asynchronous and synchronous calcium oscillations occur in a variety of cells. A well-established pathway for intercellular communication is provided by gap junctions which connect adjacent cells and can mediate electrical and chemical coupling. Several ex ...

Springer-Verlag2005

Gradient of Rigidity in the Lamellipodia of Migrating Cells Revealed by Atomic Force Microscopy

Jean-Jacques Meister, Giovanni Dietler, Alexander Verkhovskiy, Sandor Kasas, Alexandre Yersin

Changes in mechanical properties of the cytoplasm have been implicated in cell motility, but there is little information about these properties in specific regions of the cell at specific stages of the cell migration process. Fish epidermal keratocytes wit ...

2005

Weak force stalls protrusion at the leading edge of the lamellipodium

Jean-Jacques Meister, Sophie Bohnet, Alexander Verkhovskiy, Alex Mogilner

Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest ...

Elsevier2005

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Philippe Pittet, Mathieu Lamboley, Jean-Louis Bény, Michèle Koenigsberger, Roger Sauser

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005

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