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Jean-Jacques Meister

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Related publications (41)

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Emergent properties of electrically coupled smooth muscle cells

Jean-Jacques Meister, Michèle Koenigsberger

Asynchronous and synchronous calcium oscillations occur in a variety of cells. A well-established pathway for intercellular communication is provided by gap junctions which connect adjacent cells and can mediate electrical and chemical coupling. Several ex ...

Springer-Verlag2005

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Dominique Seppey

In vitro, different techniques are used to study the smooth muscle cells' calcium dynamics and contraction/relaxation mechanisms on arteries. Most experimental studies use either an isometric or an isobaric setup. However, in vivo, a blood vessel is neithe ...

2008

An actin length threshold regulates adhesion maturation at the lamellipodium/lamellum interface

Jean-Jacques Meister, Benoît Vianay, Céline Jeanne Labouesse

The mechanical coupling between adherent cells and their substrates is a major driver of downstream behavior. This coupling relies on the formation of adhesion sites and actin bundles. How cells generate these elements remains only partly understood. A pot ...

Royal Soc Chemistry2013

Tracking retrograde flow in keratocytes: news from the front

Jean-Jacques Meister, Alexander Verkhovskiy, Sophie Bohnet

Actin assembly at the leading edge of the cell is believed to drive protrusion, whereas membrane resistance and contractile forces result in retrograde flow of the assembled actin network away from the edge. Thus, cell motion and shape changes are expected ...

American Society for Cell Biology2005

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Boris Hinz, Jean-Jacques Meister, Kyumin Lee, Philippe Pittet

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

The Single-Molecule Mechanics of the Latent TGF-beta 1 Complex

Boris Hinz, Jean-Jacques Meister, Josiane Angèle Charlotte Smith-Clerc, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent

Background: TGF-beta 1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-beta 1 binds to the latent TGF-beta 1-binding protein-1 (LTBP-1), whic ...

Elsevier2011

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Jean-Louis Bény, Michèle Koenigsberger, Philippe Pittet, Mathieu Lamboley

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Boris Hinz, Jean-Jacques Meister

The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts a ...

Rockefeller University Press2007

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell

Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

Boris Hinz, Jean-Jacques Meister, Josiane Angèle Charlotte Smith-Clerc, Lara Buscemi Estefanell

Changes in the mechanical properties of dermis occur during skin aging or tissue remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic culture substrates that reproduce the variable softness of dermis, we determined ...

Nature Publishing Group2014

Stretch-elicited calcium responses in the intact mouse thoracic aorta

Jean-Jacques Meister, Jean-Louis Bény

Stretch-elicited intracellular calcium (Ca(2+)) changes in individual smooth muscle cells in a ring of aorta were measured simultaneously with the force developed by the ring. A phasic increase in Ca(2+) was observed in 30% of the cells and a sus ...

Elsevier2006

Ultrafast Ca2+ wave in cultured vascular smooth muscle cells aligned on a micropatterned surface

Jean-Jacques Meister, Jean-Louis Bény, Benoît Vianay, Jairo Camilo Quijano Perez

Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is regulated by cytosolic Ca2+ concentration (Ca2+) which propagates as Ca2+ waves over a sign ...

Elsevier2013

Gradient of Rigidity in the Lamellipodia of Migrating Cells Revealed by Atomic Force Microscopy

Giovanni Dietler, Sandor Kasas, Jean-Jacques Meister, Alexander Verkhovskiy, Alexandre Yersin

Changes in mechanical properties of the cytoplasm have been implicated in cell motility, but there is little information about these properties in specific regions of the cell at specific stages of the cell migration process. Fish epidermal keratocytes wit ...

2005

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

Jean-Jacques Meister, Jean-Louis Bény, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent

Cells with irregular shapes, numerous long thin filaments, and morphological similarities to the gastrointestinal interstitial cells of Cajal (ICCs) have been observed in the wall of some blood vessels. These ICC-like cells (ICC-LCs) do not correspond to t ...

Springer-Verlag2011

Evaluating Tension in Actomyosin Bundles at the Cell Periphery

Jean-Jacques Meister, Benoît Vianay, Niccolo Piacentini, Céline Jeanne Labouesse

Cell Press2014

Intercellular Ultrafast Calcium Wave Velocity and Propagation of Spontaneous Electrical Activity in A7r5 Cells at Physiological Temperature

Jean-Jacques Meister, Jairo Camilo Quijano Perez

Cell Press2018

Does the Endothelium Abolish or Promote Arterial Vasomotion in Rat Mesenteric Arteries? Explanations for the Seemingly Contradictory Effects