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Gerardo Turcatti

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Publications associées (56)

Loss of Protein Tyr-phosphorylation During in vitro Storage of Human Erythrocytes: Impact on RBC Morphology

Gerardo Turcatti, Pierre Marquet, Michel Prudent, Niels Erik Lion, Benjamin Rappaz

Wiley-Blackwell2014

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening

Gerardo Turcatti, Benjamin Rappaz, Etienne Shaffer

Digital Holographic Microscopy (DHM) is a label-free imaging technique allowing visualization of transparent cells with classical imaging cell culture plates. The quantitative DHM phase contrast image provided is related both to the intracellular refractiv ...

2014

Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from

Gerardo Turcatti, Damiano Banfi, Karl Gademann, Joachim Lingner, Laeticia Da Silva, Cyril Portmann, Emilie Baudat, Tom Woods

By using the Telospot assay, 27 different extracts of cyanobacteria were evaluated for telomerase inhibition. All extracts showed varying, but significant activity. We selected Microcystis aeruguinosa PCC 7806 to identify the active compound and a bioassay ...

Wiley-Blackwell2013

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

Gerardo Turcatti, Christian Depeursinge, Marc Chambon, Jonas Kühn, Pierre Magistretti, Benjamin Rappaz, Julien Mena, Jérôme Parent, Etienne Shaffer

We introduce a label-free technology based on digital holographic microscopy (DHM) with applicability for screening by imaging, and we demonstrate its capability for cytotoxicity assessment using mammalian living cells. For this first high content screenin ...

Mary Ann Liebert2013

Chemical Biology Approaches to Membrane Homeostasis and Function

Gerardo Turcatti, Kai Johnsson, Luc Reymond, Christian Heinis, Stefan Matile, Howard Riezman

The study of membranes is at a turning point. New theories about membrane structure and function have recently been proposed, however, new technologies, combining chemical, physical, and biochemical approaches are necessary to test these hypotheses. In par ...

2011

Leads for antitubercular compounds from kinase inhibitor library screens

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Stewart Cole, Sophie Magnet, Ruben Hartkoorn, Edina Rita Székely

Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find antimycobacterial scaffolds, we screened a kinase inhibitor library of more than 12,000 compounds using an integrated stra ...

2010

Preparation of nucleic acid templates for solid phase amplification

Gerardo Turcatti

The invention relates to a method of preparing template constructs for solid-phase nucleic acid amplification and to use of the templates in methods of solid-phase nucleic acid amplification. The method involves carrying out two ligation reactions: (a) a l ...

2010

Preparation of templates for nucleic acid sequencing

Gerardo Turcatti

The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to ...

2009

Method of Nucleotide Detection

Gerardo Turcatti

The invention relates to an additive which can be added to buffers used in nucleotide detection processes and improved methods of nucleic acid sequencing using this additive. In particular the invention relates to use of the additive to improve the efficie ...

2008

Accurate whole human genome sequencing using reversible terminator chemistry

Gerardo Turcatti, Ho Ling Li, Lu Zhang, Anil Kumar, Jingwen Wang

DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but the existence of reference sequences for the human and man ...

2008

A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis

Gerardo Turcatti

Fluorescent 2'-deoxynucleotides containing a protecting group at the 3'-O-position are reversible terminators enabling array-based DNA sequencing by synthesis (SBS) approaches. Herein, we describe the synthesis of a new family of 3'-OH unprotected cleavabl ...

Oxford University Press2008

Low- to high-throughput analysis of telomerase modulators with Telospot

Gerardo Turcatti, Marc Chambon, Damiano Banfi, Joachim Lingner

We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction p ...

2007

Improved method of nucleotide detection

Gerardo Turcatti

2007

Conversion of amine- to carboxyl groups on solid surfaces

Gerardo Turcatti

This invention provides a new method of obtaining a high density, reproducible and uniform coverage of a solid surface, compounds suitable for such a method and methods of preparing such compounds. This invention further relates to methods of the chemical ...

2007

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

Gerardo Turcatti

The tricarboxylate reagent benzene-1,3,5-triacetic acid (BTA) was used to attach 5'-aminated DNA primers and templates on an aminosilanized glass surface for subsequent generation of DNA colonies by in situ solid-phase amplification. We have characterized ...

Oxford University Press2006

Novel fluorescence - based approaches to probe ligand recognition and structure of the tachykinin NK2 receptor

Gerardo Turcatti

EPFL1995

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