Whole genome sequencingWhole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014.
GénomeLe génome (//), ou plus rarement génôme, est l'ensemble du matériel génétique d'une espèce codé dans son acide désoxyribonucléique (ADN), à l'exception de certains virus dont le génome est constitué d'acide ribonucléique (ARN). Il contient en particulier tous les gènes codant des protéines ou correspondant à des ARN structurés. Il se décompose donc en séquences codantes (transcrites en ARN messagers et traduites en protéines) et non codantes (non transcrites, ou transcrites en ARN, mais non traduites).
Flux (metabolism)Flux, or metabolic flux is the rate of turnover of molecules through a metabolic pathway. Flux is regulated by the enzymes involved in a pathway. Within cells, regulation of flux is vital for all metabolic pathways to regulate the pathway's activity under different conditions. Flux is therefore of great interest in metabolic network modelling, where it is analysed via flux balance analysis and metabolic control analysis.
Partage de ressourceIn computing, a shared resource, or network share, is a computer resource made available from one host to other hosts on a computer network. It is a device or piece of information on a computer that can be remotely accessed from another computer transparently as if it were a resource in the local machine. Network sharing is made possible by inter-process communication over the network. Some examples of shareable resources are computer programs, data, storage devices, and printers. E.g.
Commande DOSLes systèmes DOS sont fournis en standard avec un nombre réduit de commandes, essentiellement destinées à la gestion des disques et des fichiers (d'où le D pour Disk, ou disque en français). Il existe des commandes internes (contenues dans l'interpréteur) et des commandes externes (il faut les charger à partir d'une disquette). Les commandes DOS peuvent s'exécuter de manière interactive au sein de l'interface en ligne de commande ou en traitement par lot depuis un fichier de script portant l’extension .bat.
Clustered file systemA clustered file system is a which is shared by being simultaneously mounted on multiple servers. There are several approaches to clustering, most of which do not employ a clustered file system (only direct attached storage for each node). Clustered file systems can provide features like location-independent addressing and redundancy which improve reliability or reduce the complexity of the other parts of the cluster. Parallel file systems are a type of clustered file system that spread data across multiple storage nodes, usually for redundancy or performance.
Commentaire (informatique)vignette|Exemple de code source Java avec coloration syntaxique : le code source est en bleu, les commentaires en rouge (commentaires en bloc) et en vert (commentaires en ligne). Les commentaires sont, en programmation informatique, des portions du code source ignorées par le compilateur ou l’interpréteur, car destinées en général à un lecteur humain et non censées influencer l’exécution du programme.
Human genomeThe human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs.
Projet Génome humainvignette|Le génome humain est constitué de l'ensemble de l'information portée par nos 23 paires de chromosomes. Le (PGH, ou HGP pour l'anglais Human Genome Project) est un programme lancé fin 1988 dont la mission était d'établir le séquençage complet de l'ADN du génome humain. Son achèvement a été annoncé le . Le nouveau projet lancé dans la foulée en , ENCODE (Encyclopedia of DNA Elements), donne des résultats importants sur l'ADN non codant humain.
Reference genomeA reference genome (also known as a reference assembly) is a digital nucleic acid sequence database, assembled by scientists as a representative example of the set of genes in one idealized individual organism of a species. As they are assembled from the sequencing of DNA from a number of individual donors, reference genomes do not accurately represent the set of genes of any single individual organism. Instead a reference provides a haploid mosaic of different DNA sequences from each donor.
Métaprogrammation avec des patronsLa métaprogrammation avec des patrons est une technique de programmation dans laquelle les patrons sont utilisés de sorte que le compilateur, lors de la compilation du code, exécute un programme. Ces programmes peuvent générer des constantes ou des structures de données. Cette technique est utilisée principalement dans le langage de programmation C++. L'exemple simple de calcul de factorielle avec récursion illustre bien ce qu'est la « programmation lors de la compilation ».
Flux balance analysisFlux balance analysis (FBA) is a mathematical method for simulating metabolism in genome-scale reconstructions of metabolic networks. In comparison to traditional methods of modeling, FBA is less intensive in terms of the input data required for constructing the model. Simulations performed using FBA are computationally inexpensive and can calculate steady-state metabolic fluxes for large models (over 2000 reactions) in a few seconds on modern personal computers.
