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Concept

Lait maternel humain

Publications associées (17)

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Paul Joseph Dyson, Farzaneh Fadaei Tirani, Mouna Hadiji

Curcuminoids and their complexes continue to attract attention in medicinal chemistry, but little attention has been given to their metabolic derivatives. Here, the first examples of (arene)Ru(II) complexes with curcuminoid metabolites, tetrahydrocurcumin ...

Amer Chemical Soc2024

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Patrik Aouad, Fabio De Martino, Yueyun Zhang, Kelly Spry Maggs, Hazel Margaret Quinn, Céline Marie Victoria Stibolt

More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive due to lack of adequate in vivo m ...

Nature Research2022

Proteomics of Human Milk: Definition of a Discovery Workflow for Clinical Research Studies

Loïc Dayon

Milk is a complex biological fluid composed mainly of water, carbohydrates, lipids, proteins, and diverse bioactive factors. Human milk represents a unique tailored source of nutrients that adapts during lactation to the specific needs of the developing in ...

2021

The Quest for Genes Involved in Adaptation to Climate Change in Ruminant Livestock

Stéphane Joost, Elia Vajana

Simple Summary: After domestication in specific regions, livestock followed human migrations and colonized the whole world. During this population expansion, human and natural selection, together with demographic events, molded the livestock genome leading ...

2021

Biogeoinformatics for the management of Farm Animal Genetic Resources (FAnGR)

Solange Catherine Gaillard

In the context of both severe selection in farm animals and potential effects of climate change, it is crucial to implement a sustainable management of the breeding practice, supported by a judicious use of geographic information technologies. Based on thi ...

EPFL2020

Big dairy data to unravel effects of environmental, physiological and morphological factors on milk production of mountain-pastured Braunvieh cows

Stéphane Joost, Elia Vajana, Solange Catherine Gaillard

The transhumance system, which consists in moving animals to high mountain pastures during summer, plays a considerable role in preserving both local biodiversity and traditions, as well as protecting against natural hazard. In cows, particularly, milk pro ...

ROYAL SOC2020

Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury

Yohan Van de Looij

Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...

Wiley-Blackwell2016

Highly sensitive detection of five typical fluoroquinolones in low-fat milk by field-enhanced sample injection based CE in bubble cell capillary

Hubert Girault, Liang Qiao, Natalia Gasilova

Fluoroquinolones are a group of synthetic antibiotics with a broad activity spectrum against mycoplasma, gram-positive and gram-negative bacteria. Due to the extensive use of fluoroquinolones in farming and veterinary science, there is a constant need in t ...

Wiley-Blackwell2014

Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers

BACKGROUND: The combination of maternal obesity in early pregnancy and high protein intake in infant formula feeding might predispose to obesity risk in later life. METHODS: This study assesses the impact of breast- or formula-feeding (differing in protein ...

Nature Publishing Group2014

Microfluidic Ultrafiltration and Acoustophoresis as a Human Breast Milk Optimizing Plateform for Neonatal Nutrition

Blaise Guélat

In recent years, research has highlighted that breast milk with higher concentrations of lipid and protein could benefit to the survival rate and quality of life of preterm infants. However, to date, there is no clinical means available to separate, concen ...

EPFL2013

From food to physiology characterization and in vitro digestion of milk products and investigation of postprandial metabolism and inflammation after a high-fat meal intake in a human nutrition intervention study

Flurina Schwander

According to the World Health Organization worldwide obesity has more than doubled since 1980. The World health statistics 2012 report shows that one in six adults is obese, one in ten diabetic and one in three has a raised blood pressure. Overweight and o ...

EPFL2013

A Contextual Analysis of Land-Use and Vegetation Changes in Two Wooded Pastures in the Swiss Jura Mountains

Alexandre Buttler, François Gillet, Joël Chételat, Alexander Ludwig Johannes Peringer, Thomas Spiegelberger, Michaël Kalbermatten, Kathryn Lannas

This study examines the effects of land-use policies and natural events on the evolution of two wooded pastures in the Jura Mountains in Switzerland between 1934 and 2000. The socioeconomic context and the local conditions were seen as major driving forces ...

Resilience Alliance2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Tamara Tanos

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Nutrichip: an integrated microfluidic system for in vitro investigation of the immunemodulatory function of dairy products

Martinus Adela Maria Gijs, Sandro Carrara, Paolo Silacci, Flurina Schwander, Hamideh Jafarpoorchekab

We introduce the concept of the NutriChip, a miniaturized artificial human gastrointestinal tract (GIT) for investigating the potential of immuno-modulatory function of dairy food. More specifically, we are investigating the effect of digested milk on immu ...

2011

Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression

Cathrin Brisken

Estrogen and progesterone are the defining hormones of normal female development, and both play critical roles in breast carcinogenesis. Cyclin D1 is a breast cancer oncogene whose amplification is linked to poor prognosis in estrogen and progesterone rece ...

American Society for Microbiology2010

Occurrence of persistent toxic substances in soils, sediments, fishes and human breast milk in southern Vietnam

Global contamination and toxic effects of persistent toxic substances (PTSs) have been an emerging environmental issue and have received considerable attention during the past four decades. The rapid agricultural and industrial growths as well as the expan ...

EPFL2009

Multimedia and food chain modelling of toxics for comparative risk and life cycle impact assessment

Ralph Rosenbaum

The overall goal of this dissertation is to contribute to the development of best available practice in environmental multimedia fate and multipathway exposure modelling for human health and ecosystem impacts, addressing several important aspects. Environm ...

EPFL2006