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Concept

Rattus norvegicus

Publications associées (30)

Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury

Yohan Van de Looij

Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...

Wiley-Blackwell2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Ivan Rusev Minev, Léonie Asboth, Jérôme Gandar, Nikolaus Wenger, Arthur Edouard Hirsch, Pavel Musienko, Laetitia Danielle Philippine Baud, Natalia Pavlova, Julie Kreider

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury

Yohan Van de Looij

Objective Preterm brain injury is a major cause of disability in later life, and may result in motor, cognitive and behavioural impairment for which no treatment is currently available. The aetiology is considered as multifactorial, and one underlying key ...

Elsevier2016

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Silvestro Micera, Grégoire Courtine, Lucia Florinda Friedli Wittler, Janine Beauparlant, Jacopo Rigosa, Julie Kreider

Contrary to cats and primates, cortical contribution to hindlimb locomotor movements is not critical in rats. However, the importance of the motor cortex to regain locomotion after neurological disorders in rats suggests that cortical engagement in hindlim ...

Soc Neuroscience2016

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Jeffrey Alan Hubbell, Peter Frey, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia

Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship. Using a maternal immune activation model of schizophrenia, we tested whethe ...

Pergamon-Elsevier Science Ltd2016

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Johan Auwerx, Maria del Carmen Sandi Perez, Patrick Aebischer, Laurent Mouchiroud, Evan Graehl Williams, Dongryeol Ryu, Pénélope Andreux, Elena Katsyuba, Pooja Jha, Damien Sébastien Huzard, Giuseppe Lo Sasso, Norman Lionel Moullan

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

2016

Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T

Sarah Catherine Sonnay

In this study, we used proton-localized spectroscopy ((1) H-MRS) for the acquisition of the neurochemical profile longitudinally in a novel rat model of human wild type alpha-synuclein (a-syn) overexpression. Our goal was to find out if the increased a-syn ...

Wiley-Blackwell2016

(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism

Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Veronika Rackayová

Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and ...

Springer Verlag2016

Long Term Hippocampal and Cortical Changes Induced by Maternal Deprivation and Neonatal Leptin Treatment in Male and Female Rats

Maternal deprivation (MD) during neonatal life has diverse long-term behavioral effects and alters the development of the hippocampus and frontal cortex, with several of these effects being sexually dimorphic. MD animals show a marked reduction in their ci ...

Public Library of Science2015