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Concept

Assay

Publications associées (31)

Controlling the immobilization process of an optically enhanced protein microarray for highly reproducible immunoassay

Wen Chen

By virtue of its high throughput multiplex detection capability, superior read-out sensitivity, and tiny analyte consumption, an optically enhanced protein microarray assay has been developed as a promising diagnostic tool for various applications, ranging ...

ROYAL SOC CHEMISTRY2021

Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?"

Hilal Lashuel

Alpha-synuclein oligomerization is one of the early events on the pathway to Lewy body formation. Therefore, interfering with this process holds tremendous potential for developing therapies that block alpha-Syn pathology formation and toxicity. The develo ...

Wiley-Blackwell2021

Linear triglycerol-based fluorosurfactants show high potential for droplet-microfluidics-based biochemical assays

Esther Amstad, Irvine Lian Hao Ong

Fluorosurfactants have expanded the landscape of high-value biochemical assays in microfluidic droplets, but little is known about how the spatial geometries and polarity of the head group contribute to the performance of fluorosurfactants. To decouple thi ...

ROYAL SOC CHEMISTRY2021

Planar hydrodynamic traps and buried channels for bead and cell trapping and releasing

Philippe Renaud, Arnaud Bertsch, Daniel Migliozzi, Jonathan Bastien Cottet, Clémentine Sophie Sarah Lipp

We present a novel concept for the controlled trapping and releasing of beads and cells in a PDMS microfluidic channel without obstacles present around the particle or in the channel. The trapping principle relies on a two-level microfluidic configuration: ...

ROYAL SOC CHEMISTRY2021

Predicting exposure concentrations of chemicals with a wide range of volatility and hydrophobicity in different multi-well plate set-ups

Kristin Schirmer, Julita Maria Stadnicka-Michalak

Quantification of chemical toxicity in small-scale bioassays is challenging owing to small volumes used and extensive analytical resource needs. Yet, relying on nominal concentrations for effect determination maybe erroneous because loss processes can sign ...

NATURE RESEARCH2021

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

Maartje Martina Cornelia Bastings, Alice Comberlato

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent development of protective coating strategies prolonging structural integrity in physiological conditions. For tailored biologic ...

AMER CHEMICAL SOC2021

Printed Polymer Composite Sensors for Low-Power, Near Room-Temperature Detection and Classification of VOCS

Jürgen Brugger, Thomas Maeder, Mohammadmahdi Kiaee

We demonstrate the application of inkjet-printed near room-temperature chemiresistors composed of polymer-carbon black (CB) composites for detecting and classifying volatile organic compounds (VOC). Our results demonstrate that the printed sensors can sele ...

IEEE2021

Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing

Pablo Rivera Fuentes, Adam Miklos Eördögh

Extracellular vesicles (EVs) are emerging as promising diagnostic and therapeutic tools for a variety of diseases. The characterization of EVs requires a series of orthogonal techniques that are overall time- and material-consuming. Here, a microfluidic de ...

WILEY2021

Understanding delayed fluorescence and triplet decays of Protoporphyrin IX under hypoxic conditions

Georges Wagnières

Photosensitizers of singlet oxygen exhibit three main types of reverse intersystem-crossing (RISC): thermally activated, triplet-triplet annihilation, and singlet oxygen feedback. RISC can be followed by delayed fluorescence (DF) emission, which can provid ...

SPRINGERNATURE2021

Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish

Daniel Francis Schorderet

H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet ...

2021

The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells

Natalia Gasilova, Laure Menin, Rita Sarkis

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds' or leaves' extracts. The present study investigates the antiproliferative and antitumor activity of Annona cherimola aqueous leaf (AAL) extract/in ...

2021