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Concept

Oral mucosa

Publications associées (9)

Classification of Healthy and Cancer States of Colon Epithelial Tissues Using Opto-magnetic Imaging Spectroscopy

Marko Baros

Colorectal carcinoma (CRC) as a major health problem in industrialized countries is highly preventable and can be successfully treated in the early stages. However, incidence and mortality of CRC has increased over the last two decades. The reason could be ...

2019

Using NanoSIMS coupled with microfluidics to visualize the early stages of coral infection by Vibrio coralliilyticus

Anders Meibom, Isabelle Domart-Coulon, Emma Mary Gibbin

Background: Global warming has triggered an increase in the prevalence and severity of coral disease, yet little is known about coral/pathogen interactions in the early stages of infection. The point of entry of the pathogen and the route that they take on ...

2018

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Melody Swartz, Cathrin Brisken, Csaba Ferenc László

Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...

Nature Publishing Group2015

Is There a Need for Smooth Muscle Cell Transplantation in Urethral Reconstruction?

Peter Frey

Background: Hypospadias and urethral strictures are conditions requiring additional tissue for reconstruction. Due to a limited source of tissue, autologous skin and oral mucosa are frequently used. However, long-term follow-up studies demonstrated signifi ...

Mary Ann Liebert, Inc2014

Stem cells of stratified epithelia : a generic stem cell?

Squamous stratified epithelia tissues are self-renewing, which quality implies the existence of stem cells. In skin the presence of bona fide multipotent stem cells has been demonstrated by long-term, serial grafting assays. We isolated, cultivated and exp ...

EPFL2008

Pharmacokinetics and pharmacodynamics of tetra(m-hydroxyphenyl)chlorin in the hamster cheek pouch tumor model: comparison with clinical measurements

Hubert van den Bergh, Georges Wagnières

The pharmacokinetics (PK) of the photosensitizer tetra(m-hydroxyphenyl)chlorin (mTHPC) was measured by optical fiber-based light-induced fluorescence spectroscopy (LIFS) in the normal and tumoral cheek pouch mucosa of 29 Golden Syrian hamsters with chem. i ...

Elsevier2000

Stability of the fluorescence measurement of Foscan in the normal human oral cavity as an indicator of its content in early cancers of the esophagus and the bronchi

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) with Foscan (mTHPC) is used to cure early cancers of the esophagus or the tracheobronchial tree. However, fixed PDT parameters (drug dose, light dose, etc.) do not permit an accurate prediction of the tissue damage. Large interpa ...

1999

Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin

Hubert van den Bergh, Georges Wagnières

Objective: To clinically evaluate a new photosensitizer, m- tetra(hydroxyphenyl) chlorin (m-THPC), for the photodynamic therapy of early squamous cell carcinomas of the upper aerodigestive tract. Design: Phase 1 included evaluation of the innocuousness of ...

1997

Photodetection and photodynamic therapy of "early" squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree

Christian Depeursinge, Hubert van den Bergh, Georges Wagnières

The efficacy of photodynamic therapy (PDT) alone was evaluated on 41 ‘early’ squamous cell carcinomas of the pharynx (10), oesophagus (15) and tracheo-bronchial tree (16). All lesions but two were synchronous second primaries in ENT-patients suffering from ...

1990