Septum interventriculaire

Biomechanics of diastolic dysfunction: a one-dimensional computational modeling approach

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou, Quentin Christian Marie Michel Mercier, Karim Hesham Ahmed Kadry Abdelmeguid

Diastolic dysfunction (DD) is a major component of heart failure with preserved ejection fraction (HFpEF). Accordingly. a profound understanding of the underlying biomechanical mechanisms involved in DD is needed to elucidate all aspects of HFpEF. In this ...

AMER PHYSIOLOGICAL SOC2020

In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag

Subashika Govindan

The tracing of neuronal cell lineages is critical to our understanding of cellular diversity in the CNS. This protocol describes a fluorescence birth-dating technique to label, track and isolate isochronic cohorts of newborn cells in the CNS in vivo in mou ...

NATURE PUBLISHING GROUP2018

Experimental study of atrial fibrillation cycle length during rapid atrial septal pacing

Jean-Marc Vesin, Sasan Yazdani, Adrian Luca

Computer model-based simulations have shown that rapid stimulation at 60-100% of atrial fibrillation cycle length (AFCL) from a ring of electrodes located around the septum may induce local capture in both atria for most AF dynamics. The present study aims ...

2017

Thermodynamically consistent orthotropic activation model capturing ventricular systolic wall thickening in cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Toni Mikael Lassila, Simone Rossi

The complex phenomena underlying mechanical contraction of cardiac cells and their influence in the dynamics of ventricular contraction are extremely important in understanding the overall function of the heart. In this paper we generalize previous contrib ...

Elsevier2014

The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar

Yann Barrandon, Lukas Kappenberger, Hans-Anton Lehr

Objective: The MRL mouse strain shows extraordinary wound healing capacities. Some years ago, Leferovich et al. (Proc Natl Acad Sci U. S. A. 2001;98:9830-35) have reported the absence of scar formation after cryogenically-induced right ventricular myocardi ...

Elsevier2008

The effect of a myocardial infarction on the normalized time-varying elastance curve

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger

It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Da ...

2006