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Concept

Sélectine

Publications associées (7)

Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations

Philippe Renaud, George Coukos, Alexandre Harari, Thamani Dahoun, Margaux Catherine Marie Duchamp, Clarisse Jeanne Antonia Benoit

In this study we present a novel microfluidic hydrodynamic trapping device to probe the cell–cell interaction between all cell samples of two distinct populations. We have exploited an hydrodynamic trapping method using microfluidics to immobilize a batch ...

2019

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

Harm-Anton Klok, Solenne Desseaux

Thin, thermoresponsive polymer coatings that allow to reversibly modulate cell adhesion and detachment are attractive substrates for cell sheet engineering. Usually, this is accomplished by applying thin poly(N-isopropylacrylamide) (PNIPAM) coatings, which ...

American Chemical Society2014

Microfluidics for in vitro biomimetic shear stress-dependent leukocyte adhesion assays

Elena Bianchi

Recruitment of leukocytes from blood to tissues is a multi-step process playing a major role in the activation of inflammatory responses. Tethering and rolling of leukocytes along the vessel wall, followed by arrest and transmigration through the endotheli ...

Elsevier2013

Attomolar protein detection using a magnetic bead surface coverage assay

Martinus Adela Maria Gijs, Matteo Cornaglia, Hüseyin Cumhur Tekin

We demonstrate a microfluidic method for ultra-sensitive protein detection in serum. First, ‘large’ (2.8 μm) antibody-functionalized magnetic beads specifically capture antigen from a serum matrix under active microfluidic mixing. Subsequently, the large b ...

Royal Society of Chemistry2013

Photodynamic drug delivery enhancement in tumours does not depend on leukocyte-endothelial interaction in a human mesothelioma xenograft model

Hubert van den Bergh, Elodie Debefve, Hans-Anton Lehr

OBJECTIVES: The pre-treatment of tumour neovessels by low-level photodynamic therapy (PDT) improves the distribution of concomitantly administered systemic chemotherapy. The mechanism by which PDT permeabilizes the tumour vessel wall is only partially know ...

Oxford University Press2012

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Melody Swartz

RATIONALE: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is important for both adaptive immunity and maintenance of tolerance to self-antigens. Lymphatic drainage can change rapidly and dramatically on tissue injury or infl ...

American Heart Association2010

FcRgamma activation regulates inflammation-associated squamous carcinogenesis

Michele De Palma

Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mo ...

2010