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Concept

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Publications associées (24)

Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

BACKGROUND: Stereotactic radiosurgery (SRS) is one of the main treatment options in the management of small to medium size vestibular schwannomas (VSs), because of high tumor control rate and low cranial nerves morbidity. Series reporting long-term hearing ...

LIPPINCOTT WILLIAMS & WILKINS2023

Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study

Thorsten Kleinjung, Patrick Karl Alois Neff

We performed magnetic resonance spectroscopy (MRS) on healthy individuals with tinnitus and no hearing loss (n = 16) vs. a matched control group (n = 17) to further elucidate the role of excitatory and inhibitory neurotransmitters in tinnitus. Two-dimensio ...

Nature Research2022

Repeat stereotactic radiosurgery for progressive vestibular schwannomas after previous radiosurgery: a systematic review and meta-analysis

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

Vestibular schwannomas (VS) are slow-growing intracranial extraaxial benign tumors, developing from the vestibular part of the eight cranial nerves. Stereotactic radiosurgery (SRS) has now a long-term scientific track record as first intention treatment fo ...

SPRINGER2021

Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

Oxford University Press2021

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Optimal visuo-vestibular integration for self-motion perception in patients with unilateral vestibular loss

Olaf Blanke, Mariia Kaliuzhna, Steven Gale

Unilateral vestibular loss (UVL) is accompanied by deficits in processing of visual and vestibular self-motion cues. The present study examined whether multisensory integration of these two types of information is, nevertheless, intact in such patients. Pa ...

2018

Vestibular modulation of peripersonal space boundaries

Olaf Blanke, Andrea Serino, Christian Pfeiffer

Human-environment interactions are mediated through the body and occur within the peripersonal space (PPS), the space immediately adjacent to and surrounding the body. The PPS is taken to be a critical interface between the body and the environment, and in ...

2018

Differential effects of vestibular processing on orienting exogenous and endogenous covert visual attention

Olaf Blanke, Andrea Serino, Mariia Kaliuzhna, Steve Michel Berger

Recent research highlights the overwhelming role of vestibular information for higher order cognition. Central to body perception, vestibular cues provide information about self-location in space, self-motion versus object motion, and modulate the percepti ...

2019

A real-time optimal inverse planning for Gamma Knife radiosurgery by convex optimization: description of the system and first dosimetry data

Jean-Philippe Thiran, Rafael Eduardo Carrillo Rangel, Rémi Charrier

OBJECTIVE The authors developed a new, real-time interactive inverse planning approach, based on a fully convex framework, to be used for Gamma Knife radiosurgery. ...

AMER ASSOC NEUROLOGICAL SURGEONS2018

Study of tonotopic brain changes with functional MRI and FDG-PET in a patient with unilateral objective cochlear tinnitus

Melissa Saenz

We studied possible brain changes with functional MRI (fMRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) in a patient with a rare, high-intensity "objective tinnitus" (high-level SOAEs) in the left ear of 10 years duration, with no associ ...

Elsevier2016

Distinct vestibular effects on early and late somatosensory cortical processing in humans

Olaf Blanke, Fosco Bernasconi, Michiel van Elk, Christian Pfeiffer

In non-human primates several brain areas contain neurons that respond to both vestibular and somatosensory stimulation. In humans, vestibular stimulation activates several somatosensory brain regions and improves tactile perception. However, less is known ...

Academic Press Inc Elsevier Science2016

Balancing the Self

Mariia Kaliuzhna

The vestibular system is composed of otolith organs and semi-circular canals that encode linear and angular accelerations, as well as the position of the head with respect to gravity. Thus, the detection of self-motion, the distinction between self- and ob ...

EPFL2015

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Alessandro Daducci, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, Cristina Granziera, David Paul Roger Romascano, Alexis Roche, Jonas Richiardi, Ying-Chia Lin, Guillaume Bonnier

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Imagined own-body transformations during passive self-motion

Olaf Blanke, Michiel van Elk

Spatial perspective taking is a crucial social skill that underlies many of our everyday interactions. Previous studies have suggested that spatial perspective taking is an embodied process that involves the integration of both motor and proprioceptive inf ...

2014

A real-time research platform to study vestibular implants with gyroscopic inputs in vestibular deficient subjects

Silvestro Micera, John Francis Di Giovanna

Researchers have succeeded in partly restoring damaged vestibular functionality in several animal models. Recently, acute interventions have also been demonstrated in human patients. Our previous work on a vestibular implant for humans used predefined stim ...

2014

Nobel Prize centenary: Robert Barany and the vestibular system

Olaf Blanke

The hundredth anniversary of Robert Barany's Nobel Prize in Medicine offers the opportunity to highlight the importance of his discoveries on the physiology and pathophysiology of the vestibular organs. Barany developed the method of caloric vestibular sti ...

Cell Press2014

Multisensory Origin of the Subjective First-Person Perspective: Visual, Tactile, and Vestibular Mechanisms

Olaf Blanke, Roberto Martuzzi, Christian Pfeiffer, Valentin Marc Schmutz, Julio Duenas

In three experiments we investigated the effects of visuo-tactile and visuo-vestibular conflict about the direction of gravity on three aspects of bodily self-consciousness: self-identification, self-location, and the experienced direction of the first-per ...

Public Library of Science2013

Abnormal self-location and vestibular vertigo in a patient with right frontal lobe epilepsy

Olaf Blanke, Lukas Heydrich

We describe the case of a 33-year-old man with complex partial seizures characterized by the feeling of being projected outside his body, including dissociation of "mind and self from body" (disembodiment), followed by vestibular vertigo due to right front ...

Elsevier2010

How vestibular stimulation interacts with illusory hand ownership

Olaf Blanke

Artificial stimulation of the peripheral vestibular system has been shown to improve ownership of body parts in neurological patients, suggesting vestibular contributions to bodily self-consciousness. Here, we investigated whether galvanic vestibular stimu ...

Elsevier2010

How body position changes visual vertical perception after unilateral vestibular loss

Visual vertical perception, posture and equilibrium are impaired in patients with a unilateral vestibular loss. The present study was designed to investigate whether body position (standing upright, sitting on a chair and lying supine) influences the visua ...

2008